Multifunctional Magneto-Polymeric Nanohybrids for Targeted Detection and Synergistic Therapeutic Effects on Breast Cancer†
Jaemoon Yang
Department of Chemical Engineering, Yonsei University, Seoul 120-749, Korea, Fax: (+82)2-312-6401
Search for more papers by this authorChoong-Hwan Lee
Advanced Technology Research Center, ATGen, 68 Yatap-dong, Bundang-gu, Seongnam, Gyeonggi, 463-816, Korea
Search for more papers by this authorHyun-Ju Ko
Department of Radiology & Department of Biochemistry and Molecular Biology, Yonsei University, Seoul 120-752, Korea, Fax: (+82) 2-312-6401 http://microrxn.yonsei.ac.kr
Search for more papers by this authorJin-Suck Suh Prof.
Department of Radiology & Department of Biochemistry and Molecular Biology, Yonsei University, Seoul 120-752, Korea, Fax: (+82) 2-312-6401 http://microrxn.yonsei.ac.kr
Search for more papers by this authorHo-Geun Yoon Prof.
Department of Radiology & Department of Biochemistry and Molecular Biology, Yonsei University, Seoul 120-752, Korea, Fax: (+82) 2-312-6401 http://microrxn.yonsei.ac.kr
Search for more papers by this authorKwangyeol Lee Prof.
Department of Chemistry, Korea University, Seoul 136-701, Korea
Search for more papers by this authorYong-Min Huh Prof.
Department of Radiology & Department of Biochemistry and Molecular Biology, Yonsei University, Seoul 120-752, Korea, Fax: (+82) 2-312-6401 http://microrxn.yonsei.ac.kr
Search for more papers by this authorSeungjoo Haam Prof.
Department of Chemical Engineering, Yonsei University, Seoul 120-749, Korea, Fax: (+82)2-312-6401
Search for more papers by this authorJaemoon Yang
Department of Chemical Engineering, Yonsei University, Seoul 120-749, Korea, Fax: (+82)2-312-6401
Search for more papers by this authorChoong-Hwan Lee
Advanced Technology Research Center, ATGen, 68 Yatap-dong, Bundang-gu, Seongnam, Gyeonggi, 463-816, Korea
Search for more papers by this authorHyun-Ju Ko
Department of Radiology & Department of Biochemistry and Molecular Biology, Yonsei University, Seoul 120-752, Korea, Fax: (+82) 2-312-6401 http://microrxn.yonsei.ac.kr
Search for more papers by this authorJin-Suck Suh Prof.
Department of Radiology & Department of Biochemistry and Molecular Biology, Yonsei University, Seoul 120-752, Korea, Fax: (+82) 2-312-6401 http://microrxn.yonsei.ac.kr
Search for more papers by this authorHo-Geun Yoon Prof.
Department of Radiology & Department of Biochemistry and Molecular Biology, Yonsei University, Seoul 120-752, Korea, Fax: (+82) 2-312-6401 http://microrxn.yonsei.ac.kr
Search for more papers by this authorKwangyeol Lee Prof.
Department of Chemistry, Korea University, Seoul 136-701, Korea
Search for more papers by this authorYong-Min Huh Prof.
Department of Radiology & Department of Biochemistry and Molecular Biology, Yonsei University, Seoul 120-752, Korea, Fax: (+82) 2-312-6401 http://microrxn.yonsei.ac.kr
Search for more papers by this authorSeungjoo Haam Prof.
Department of Chemical Engineering, Yonsei University, Seoul 120-749, Korea, Fax: (+82)2-312-6401
Search for more papers by this authorWe thank Prof. Kunhong Kim at Yonsei University for the insightful discussion. This work was supported by KOSEF through National Core Research Center for Nanomedical Technology (R15-2004-024-00000-0 and R01-2006-000-10023-0, and KOSEF 2007-8-1158), the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea (0620190-1).
Graphical Abstract
Diagnosis and treatment all in one: Multifunctional magneto-polymeric nanohybrids (MMPNs) have been synthesized using ultrasensitive MnFe2O4 nanocrystals, chemotherapeutic agents, and encapsulating amphiphilic block copolymers for targeted detection by MRI and treatment of breast cancer. See the TEM image (left) of an MMPN and T2-weighted MR images (top row) and color map (bottom row) of the relaxivity R2 for NIH3T6.7 and MDA-MB-231 cells.
Supporting Information
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References
- 1
- 1aA. P. Alivisatos, Science 1996, 271, 933–937;
- 1bR. E. Bailey, S. Nie, J. Am. Chem. Soc. 2003, 125, 7100–7106;
- 1cS. Kim, B. Fisher, H.-J. Eisler, M. Bawendi, J. Am. Chem. Soc. 2003, 125, 11466–11467;
- 1dS. Kim, Y. T. Lim, E. G. Soltesz, A. M. De Grand, J. Lee, A. Nakayama, J. A. Parker, T. Mihaljevic, R. G. Laurence, D. M. Dor, L. H. Cohn, M. G. Bawendi, J. V. Frangioni, Nat. Biotechnol. 2004, 22, 93–97;
- 1eB.-S. Kim, J. M. Qiu, J. P. Wang, T. A. Taton, Nano Lett. 2005, 5, 1987–1991.
- 2
- 2aY. Jun, Y.-M Huh, J. Choi, J. Lee, H. Song, S. Kim, S. Yoon, S. Kim, J. Shin, J. Suh, J. Cheon, J. Am. Chem. Soc. 2005, 127, 5732–5733;
- 2bD. Artemov, N. Mori, B. Okollie, Z. M. Bhujwalla, Magn. Reson. Med. 2003, 49, 403–408;
- 2cY.-M Huh, Y. Jun, H. Song, Kim, S. J. Choi, J. Lee, S. Yoon, K. Kim, J. Shin, J. Suh, J. Cheon, J. Am. Chem. Soc. 2005, 127, 12387–12391;
- 2dJ. Lee, Y.-M Huh, Y. Jun, J. Seo, J. Jang, H. Song, S. Kim, E. Cho, H. Yoon, J. Suh, J. Cheon, Nat. Med. 2007, 13, 95–99.
- 3
- 3aX. Michalet, F. F. Pinaud, L. A. Bentolila, J. M. Tsay, S. Doose, J. J. Li, G. Sundaresan, A. M. Wu, S. S. Gambhir, S. Weiss, Science 2005, 307, 538–544;
- 3bO. C. Farokhzad, J. Cheng, B. A. Teply, I. Sherifi, S. Jon, P. W. Richie, J. P. Kantoff, R. Langer, Proc. Natl. Acad. Sci. USA 2006, 103, 6315–6320;
- 3cS. Sengupta, D. Eavarone, I. Capila, G. Zhao, N. Watson, T. Kiziltepe, R. Sasisekharan, Nature 2005, 436, 568–572;
- 3dH. Wartlick, K. Michaelis, S. Balthasar, K. Strebhardt, J. Kreuter, K. Langer, J. Drug Targeting 2004, 12, 461- 471;
- 3eJ. Yang, S. B. Park, H. G. Yoon, Y.-M. Huh, S. Haam, Int. J. Pharm. 2006, 324, 185–190;
- 3fA. Koide, A. Kishimura, K. Osada, W.-D. Jang, Y. Yamasaki, K. Kataoka, J. Am. Chem. Soc. 2006, 128, 5988–5989.
- 4S. Sun, H. Zeng, D. B. Robinson, S. Raoux, P. M. Rice, S. X. Wang, G. Li, J. Am. Chem. Soc. 2004, 126, 273–279.
- 5
- 5aJ. M. Perez, L. Josephson, T. O'Loughlin, D. Hogemann, R. Weissleder, Nat. Biotechnol. 2002, 20, 816–820;
- 5bJ.-F. Berret, N. Schonbeck, F. Gazeau, D. El Kharrat, O. Sandre, A. Vacher, M. Airiau, J. Am. Chem. Soc. 2006, 128, 1755–1761.
- 6R. M. Hudziak, G. D. Lewis, M. Winget, B. M. Fendly, H. M. Shepard, A. Ullrich, Mol. Cell. Biol. 1989, 9, 1165–1172.
- 7A. K. Iyer, G. Khaled, J. Fang, H. Maeda, Drug Discovery Today 2006, 11, 812–818.
- 8
- 8aP. R. Mishra, N. K. Jain, Drug Delivery 2003, 10, 277–282;
- 8bM. Kovar, T. Mrkvan, J. Strohalm, T. Etrych, K. Ulbrich, M. Stastny, B. Rihova, J. Controlled Release 2003, 92, 315–330;
- 8cH. S. Yoo, J. E. Oh, K. H. Lee, T. G. Park, Pharm. Res. 1999, 16, 1114–1118;
- 8dS. Q. Liu, Y. W. Tong, Yi-Yan Yang, Biomaterials 2005, 26, 5064–5074;
- 8eH. S. Yoo, T.G Park, J. Controlled Release 2001, 70, 63–70.
- 9
- 9aZ. Li, L. Wei, M. Gao, H. Lei, Adv. Mater. 2005, 17, 1001–1007;
- 9bC. A. Cuenod, L. Fournier, D. Balvay, J.-M. Guinebretière, Abdom. Imaging 2006, 31, 188–194.
