Communication
Photoamplification and Multiple Tag Release in a Linear Peptide-Based Array of Dithiane Adducts†
†
This work is supported by NSF and NIH.
Graphical Abstract
Binary encoding and amplification can be achieved in linear polypeptide-based scaffolds of photoactive dithiane adducts. QA masked sensitizer is tethered to lysine and incorporated in a peptide chain terminated with a sensitizer (see picture). When illuminated, the sensitizer induces fragmentation, thus unmasking more sensitizer and resulting in a linear domino photoamplification effect.
