Volume 44, Issue 42 pp. 6863-6866
Communication

Sandwich Immunoassay as a High-Throughput Screening Method for Cross-Coupling Reactions

Paola Vicennati Dr.

Paola Vicennati Dr.

Service de Marquage Moléculaire et de Chimie Bio-Organique, DSV/DBJC CEA Saclay, 91191 Gif sur Yvette Cedex, France, Fax: (+33) 1-6908-7991

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Nicolas Bensel Dr.

Nicolas Bensel Dr.

Novalyst Discovery, 23 rue du Loess–BP 20, 67037 Strasbourg, France

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Alain Wagner Dr.

Alain Wagner Dr.

Novalyst Discovery, 23 rue du Loess–BP 20, 67037 Strasbourg, France

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Christophe Créminon Dr.

Christophe Créminon Dr.

Service de Pharmacologie et d'Immunologie, DRM/DSV CEA Saclay, 91191 Gif-sur-Yvette Cedex, France

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Frédéric Taran Dr.

Frédéric Taran Dr.

Service de Marquage Moléculaire et de Chimie Bio-Organique, DSV/DBJC CEA Saclay, 91191 Gif sur Yvette Cedex, France, Fax: (+33) 1-6908-7991

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First published: 25 October 2005
Citations: 33

Financial support from the European community (IBAAC project) is gratefully acknowledged. The authors also thank D. Buisson and S. Gabillet for assistance with the HPLC and product synthesis.

Graphical Abstract

Catalyst sandwich: An efficient and sensitive high-throughput-screening method that uses sandwich immunoassays was developed and applied to the Sonogashira reaction. This new method is amenable to coupling reactions and allows the screening of more than 1000 catalyst samples per day.

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