A Cobaltocenium–Peptide Bioconjugate Shows Enhanced Cellular Uptake and Directed Nuclear Delivery
Fozia Noor
Institut für Pharmazie und Molekulare Biotechnologie, Universität Heidelberg, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany, Fax: (+49) 6221-54-64-41
Search for more papers by this authorAnnette Wüstholz
Institut für Pharmazie und Molekulare Biotechnologie, Universität Heidelberg, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany, Fax: (+49) 6221-54-64-41
Search for more papers by this authorRalf Kinscherf Priv.-Doz. Dr.
Institut für Anatomie und Zellbiologie, Universität Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
Search for more papers by this authorNils Metzler-Nolte Prof. Dr.
Institut für Pharmazie und Molekulare Biotechnologie, Universität Heidelberg, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany, Fax: (+49) 6221-54-64-41
Search for more papers by this authorFozia Noor
Institut für Pharmazie und Molekulare Biotechnologie, Universität Heidelberg, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany, Fax: (+49) 6221-54-64-41
Search for more papers by this authorAnnette Wüstholz
Institut für Pharmazie und Molekulare Biotechnologie, Universität Heidelberg, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany, Fax: (+49) 6221-54-64-41
Search for more papers by this authorRalf Kinscherf Priv.-Doz. Dr.
Institut für Anatomie und Zellbiologie, Universität Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
Search for more papers by this authorNils Metzler-Nolte Prof. Dr.
Institut für Pharmazie und Molekulare Biotechnologie, Universität Heidelberg, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany, Fax: (+49) 6221-54-64-41
Search for more papers by this authorGraphical Abstract
The key to the cells: The N-terminal organometallic complex shown greatly improves cellular uptake of a bioconjugate containing the NLS peptide (NLS=nuclear localization sequence) and cobaltocenium carboxylic acid. Nuclear localization of this novel organometallic bioconjugate in HepG2 cells is demonstrated by live-cell fluorescence microscopy (see picture). FITC=fluorescein isothiocyanate.
Supporting Information
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