Synthesis and Manipulation of Orthogonally Protected Dendrimers: Building Blocks for Library Synthesis†
Mackay B. Steffensen
Texas A&M University, Department of Chemistry, College Station, TX 77843-3255, USA, Fax: (+1) 979-845-9452
Search for more papers by this authorEric E. Simanek Dr.
Texas A&M University, Department of Chemistry, College Station, TX 77843-3255, USA, Fax: (+1) 979-845-9452
Search for more papers by this authorMackay B. Steffensen
Texas A&M University, Department of Chemistry, College Station, TX 77843-3255, USA, Fax: (+1) 979-845-9452
Search for more papers by this authorEric E. Simanek Dr.
Texas A&M University, Department of Chemistry, College Station, TX 77843-3255, USA, Fax: (+1) 979-845-9452
Search for more papers by this authorThis work was supported by a grant from the N.I.H. (NIGMS 64650). M.B.S. received a predoctoral fellowship from the Chemistry-Biology Training Grant (NIH TM GM08523).
Graphical Abstract
Fruits of the laboratory: Dendrimers containing up to six different functional groups can be prepared in multistep one-pot reactions by using a selective manipulation and deprotection strategy (see example). The authors call these multifunctional dendrimers molecular fruit-salad trees; they could function as useful building blocks for drug-delivery systems and novel materials.
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