Volume 43, Issue 10 pp. 1287-1290

Communication

Molecularly Imprinted Polymers with Strong Carboxypeptidase A-Like Activity: Combination of an Amidinium Function with a Zinc-Ion Binding Site in Transition-State Imprinted Cavities^†

Jun-qiu Liu Prof. Dr.,

Jun-qiu Liu Prof. Dr.

Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, 130023, P.R. China

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Günter Wulff Prof. Dr.,

Günter Wulff Prof. Dr.

[email protected]

Institute of Organic Chemistry and Macromolecular Chemistry, Heinrich-Heine-University Düsseldorf, Universitaetsstrasse 1, 40225 Düsseldorf, Germany, Fax: (+49) 211-811-5840

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Jun-qiu Liu Prof. Dr.,

Jun-qiu Liu Prof. Dr.

Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, 130023, P.R. China

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Günter Wulff Prof. Dr.,

Günter Wulff Prof. Dr.

[email protected]

Institute of Organic Chemistry and Macromolecular Chemistry, Heinrich-Heine-University Düsseldorf, Universitaetsstrasse 1, 40225 Düsseldorf, Germany, Fax: (+49) 211-811-5840

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First published: 25 February 2004

https://doi.org/10.1002/anie.200352770

Citations: 129

^†

This research was supported by Deutsche Forschungsgemeinschaft and Fonds der Chemischen Industrie. J.-q. Liu acknowledges a fellowship from the Alexander von Humboldt Foundation. Helpful discussions with Prof. Dr. W. Kläui, Institute of Inorganic Chemistry of our university are greatly acknowledged.

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Graphical Abstract

Impressing models: A novel polymer catalyst shows even higher catalytic activity for the hydrolysis of carbonates than catalytic antibodies prepared for the same purpose. The catalyst was prepared by molecular imprinting with a stable transition state analogue and the introduction of an amidinium function and a Zn²⁺ ion in the active site in a defined orientation (see picture).

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Volume43, Issue10

February 27, 2004

Pages 1287-1290

Molecularly Imprinted Polymers with Strong Carboxypeptidase A-Like Activity: Combination of an Amidinium Function with a Zinc-Ion Binding Site in Transition-State Imprinted Cavities^†

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Molecularly Imprinted Polymers with Strong Carboxypeptidase A-Like Activity: Combination of an Amidinium Function with a Zinc-Ion Binding Site in Transition-State Imprinted Cavities†

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Supporting Information

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Molecularly Imprinted Polymers with Strong Carboxypeptidase A-Like Activity: Combination of an Amidinium Function with a Zinc-Ion Binding Site in Transition-State Imprinted Cavities^†