Spiky Artificial Peroxidases with V−O−Fe Pair Sites for Combating Antibiotic-Resistant Pathogens
Haoju Huang
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065 China
Search for more papers by this authorWei Geng
Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorXizheng Wu
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065 China
Search for more papers by this authorYiyun Zhang
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065 China
Search for more papers by this authorLan Xie
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065 China
Search for more papers by this authorTian Ma
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065 China
Search for more papers by this authorCorresponding Author
Prof. Chong Cheng
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065 China
Med-X Center for Materials, Sichuan University, Chengdu, 610065 China
Search for more papers by this authorHaoju Huang
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065 China
Search for more papers by this authorWei Geng
Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorXizheng Wu
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065 China
Search for more papers by this authorYiyun Zhang
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065 China
Search for more papers by this authorLan Xie
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065 China
Search for more papers by this authorTian Ma
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065 China
Search for more papers by this authorCorresponding Author
Prof. Chong Cheng
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065 China
Med-X Center for Materials, Sichuan University, Chengdu, 610065 China
Search for more papers by this authorAbstract
With the sharp rise of antibiotic-resistant pathogens worldwide, it is of enormous importance to create new strategies for combating pathogenic bacteria. Here, we create an iron oxide-based spiky artificial peroxidase (POD) with V−O−Fe pair sites (V-Fe2O3) for combating methicillin-resistant Staphylococcus aureus (MRSA). The experimental studies and theoretical calculations demonstrate that the V-Fe2O3 can achieve the localized “capture and killing” bifunction from the spiky morphology and massive reactive oxygen species (ROS) production. The V-Fe2O3 can reach nearly 100 % bacterial inhibition over a long period by efficiently oxidizing the lipid membrane. Our wound disinfection results identify that the V-Fe2O3 can not only efficiently eliminate MRSA and their biofilm but also accelerate wound recovery without causing noticeable inflammation and toxicity. This work offers essential insights into the critical roles of V−O−Fe pair sites and localized “capture and killing” in biocatalytic disinfection and provides a promising pathway for the de novo design of efficient artificial peroxidases.
Conflict of interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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