Nickel-Hydride-Catalyzed Diastereo- and Enantioselective Hydroalkylation of Cyclopropenes
Qingqin Huang
Joint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Binhai New City, Fuzhou, Fujian, 350207 China
Department of Chemistry, National University of Singapore, 3 Science Drive 3, 117543 Singapore, Singapore
These authors contributed equally to this work.
Search for more papers by this authorYa Chen
Department of Chemistry, National University of Singapore, 3 Science Drive 3, 117543 Singapore, Singapore
These authors contributed equally to this work.
Search for more papers by this authorXueting Zhou
Joint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Binhai New City, Fuzhou, Fujian, 350207 China
Department of Chemistry, National University of Singapore, 3 Science Drive 3, 117543 Singapore, Singapore
Search for more papers by this authorLei Dai
Department of Chemistry, National University of Singapore, 3 Science Drive 3, 117543 Singapore, Singapore
Search for more papers by this authorCorresponding Author
Yixin Lu
Joint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Binhai New City, Fuzhou, Fujian, 350207 China
Department of Chemistry, National University of Singapore, 3 Science Drive 3, 117543 Singapore, Singapore
Search for more papers by this authorQingqin Huang
Joint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Binhai New City, Fuzhou, Fujian, 350207 China
Department of Chemistry, National University of Singapore, 3 Science Drive 3, 117543 Singapore, Singapore
These authors contributed equally to this work.
Search for more papers by this authorYa Chen
Department of Chemistry, National University of Singapore, 3 Science Drive 3, 117543 Singapore, Singapore
These authors contributed equally to this work.
Search for more papers by this authorXueting Zhou
Joint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Binhai New City, Fuzhou, Fujian, 350207 China
Department of Chemistry, National University of Singapore, 3 Science Drive 3, 117543 Singapore, Singapore
Search for more papers by this authorLei Dai
Department of Chemistry, National University of Singapore, 3 Science Drive 3, 117543 Singapore, Singapore
Search for more papers by this authorCorresponding Author
Yixin Lu
Joint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Binhai New City, Fuzhou, Fujian, 350207 China
Department of Chemistry, National University of Singapore, 3 Science Drive 3, 117543 Singapore, Singapore
Search for more papers by this authorAbstract
Cyclopropanes are structural motifs that are widely present in natural products and bioactive molecules, and they are also tremendously useful building blocks in synthetic organic chemistry. Asymmetric synthesis of cyclopropane derivatives has been an intensively researched area over the years, but efficient asymmetric preparation of alkylcyclopropane scaffolds remains a challenging topic. Herein, we report a nickel-hydride-catalyzed enantioselective and diastereoselective hydroalkylation of cyclopropenes for facile synthesis of chiral alkylcyclopropane motifs. The reported method is efficient and versatile, taking place under mild reaction conditions, and having broad applicability and excellent functional group tolerance.
Open Research
Data Availability Statement
The data that support the findings of this study are available in the Supporting Information of this article.
Supporting Information
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| ange202210560-sup-0001-M100.cif1.3 MB | Supporting Information |
| ange202210560-sup-0001-misc_information.pdf9.9 MB | Supporting Information |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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