Near-Infrared Light-Triggered Chlorine Radical (.Cl) Stress for Cancer Therapy
Ruixue Song
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062 P. R. China
Search for more papers by this authorDr. Han Wang
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China
Search for more papers by this authorDr. Meng Zhang
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China
Search for more papers by this authorCorresponding Author
Prof. Yanyan Liu
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062 P. R. China
Department of Materials Science, Fudan University, Shanghai, 200433 P. R. China
Search for more papers by this authorDr. Xianfu Meng
Tongji University Cancer Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072 P. R. China
Search for more papers by this authorShaojie Zhai
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China
Search for more papers by this authorDr. Chao-chao Wang
Tongji University Cancer Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072 P. R. China
Search for more papers by this authorDr. Teng Gong
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062 P. R. China
Search for more papers by this authorProf. Yelin Wu
Tongji University Cancer Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072 P. R. China
Search for more papers by this authorDr. Xingwu Jiang
Department of Materials Science, Fudan University, Shanghai, 200433 P. R. China
Search for more papers by this authorCorresponding Author
Prof. Wenbo Bu
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062 P. R. China
Department of Materials Science, Fudan University, Shanghai, 200433 P. R. China
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China
Search for more papers by this authorRuixue Song
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062 P. R. China
Search for more papers by this authorDr. Han Wang
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China
Search for more papers by this authorDr. Meng Zhang
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China
Search for more papers by this authorCorresponding Author
Prof. Yanyan Liu
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062 P. R. China
Department of Materials Science, Fudan University, Shanghai, 200433 P. R. China
Search for more papers by this authorDr. Xianfu Meng
Tongji University Cancer Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072 P. R. China
Search for more papers by this authorShaojie Zhai
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China
Search for more papers by this authorDr. Chao-chao Wang
Tongji University Cancer Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072 P. R. China
Search for more papers by this authorDr. Teng Gong
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062 P. R. China
Search for more papers by this authorProf. Yelin Wu
Tongji University Cancer Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072 P. R. China
Search for more papers by this authorDr. Xingwu Jiang
Department of Materials Science, Fudan University, Shanghai, 200433 P. R. China
Search for more papers by this authorCorresponding Author
Prof. Wenbo Bu
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062 P. R. China
Department of Materials Science, Fudan University, Shanghai, 200433 P. R. China
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China
Search for more papers by this authorAbstract
Free radicals with reactive chemical properties can fight tumors without causing drug resistance. Reactive oxygen species (ROS) has been widely used for cancer treatment, but regrettably, the common O2 and H2O2 deficiency in tumors sets a severe barrier for sufficient ROS production, leading to unsatisfactory anticancer outcomes. Here, we construct a chlorine radical (.Cl) nano-generator with SiO2-coated upconversion nanoparticles (UCNPs) on the inside and Ag0/AgCl hetero-dots on the outside. Upon near-infrared (NIR) light irradiation, the short-wavelength emission UCNP catalyzes .Cl generation from Ag0/AgCl with no dependence on O2/H2O2. .Cl with strong oxidizing capacity and nucleophilicity can attack biomolecules in cancer cells more effectively than ROS. This .Cl stress treatment will no doubt broaden the family of oxidative stress-induced antitumor strategies by using non-oxygen free radicals, which is significant in the development of new anticancer agents.
Conflict of interest
The authors declare no conflict of interest.
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