Cancer Therapies Based on Stimuli-Responsive Materials
Giuliana Mosconi
Instituto de Investigaciones en Físico-química de Córdoba (INFIQC), CONICET, Av. Haya de la Torre s/n, Córdoba, X5000HUA Argentina
Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Departamento de Fisicoquímica, Av. Haya de la Torre s/n, Córdoba, X5000HUA Argentina
Search for more papers by this authorMicaela A. Macchione
Centro de Investigaciones y Transferencia de Villa María (CIT Villa María), CONICET-UNVM, Arturo Jauretche 1555, Villa María, X5900LQC Argentina
Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Departamento de Química Orgánica, Av. Haya de la Torre esq. Medina Allende, Córdoba, X5000HUA Argentina
Search for more papers by this authorMarcelo R. Romero
Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Departamento de Química Orgánica, Av. Haya de la Torre esq. Medina Allende, Córdoba, X5000HUA Argentina
Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada (IPQA), CONICET, Av. Velez Sarsfield 1611, Córdoba, X5000HUA Argentina
Search for more papers by this authorGiuliana Mosconi
Instituto de Investigaciones en Físico-química de Córdoba (INFIQC), CONICET, Av. Haya de la Torre s/n, Córdoba, X5000HUA Argentina
Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Departamento de Fisicoquímica, Av. Haya de la Torre s/n, Córdoba, X5000HUA Argentina
Search for more papers by this authorMicaela A. Macchione
Centro de Investigaciones y Transferencia de Villa María (CIT Villa María), CONICET-UNVM, Arturo Jauretche 1555, Villa María, X5900LQC Argentina
Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Departamento de Química Orgánica, Av. Haya de la Torre esq. Medina Allende, Córdoba, X5000HUA Argentina
Search for more papers by this authorMarcelo R. Romero
Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Departamento de Química Orgánica, Av. Haya de la Torre esq. Medina Allende, Córdoba, X5000HUA Argentina
Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada (IPQA), CONICET, Av. Velez Sarsfield 1611, Córdoba, X5000HUA Argentina
Search for more papers by this authorSenentxu Lanceros-Méndez
Basque Center for Materials Applications, UPV/EHU Science Park, Leioa, 48940 Spain
Search for more papers by this authorClarisse Ribeiro
Universidade do Minho, Braga, 4710-057 Portugal
Search for more papers by this authorUnai Silván
Basque Center Mater, Appl, Nanostruc, UPV/EHU Science Park, Leioa, 48940 Spain
Search for more papers by this authorSummary
This chapter discusses the recent progress made using stimuli-responsive materials in cancer therapy, focusing on advanced drug delivery systems involving smart polymers (e.g., shape-memory materials). They exhibit the ability to react to different external stimuli, i.e., temperature, pH, or light, that bring about accurate and spatial release of a payload in the tumor. This chapter resumes the synthesis, characterization, and functionalization of such materials, focusing on their capacity to improve cancer treatment efficiency and decrease undesirable side effects. The new materials also raise questions about integrating them in the clinic, including biocompatibility, degradation, and issues surrounding the complexity of the tumor microenvironment. The chapter highlights the pivotal role of smarting materials in advancing personalized cancer therapy by discussing recent developments and showcasing case studies. They review the current research, help identify relevant areas, and provide examples where translational cancer can bridge experimental studies observed in animals into targeted therapy to be treated or surgery by humans.
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