Pharmaceutical dosage forms are complex devices to deliver active pharmaceutical ingredients to patients. This chapter explores the pharmaceutically used three-dimensional (3D) printing processes and techniques. The process flow of 3D printing processes is similar for all printing techniques. Inkjet printing is the process of jetting small droplets of ink on a substrate. The common characteristic of extrusion-based printing is the forced movement of plasticized material through a nozzle and the deposition of the extruded material on a printing bed. Stereolithography and selective laser sintering utilize lasers to solidify materials to 3D objects. The chapter focuses on modifying the drug release profile from 3D printed dosage forms. 3D printing offers several approaches to modify the release profile from dosage forms. The formulation development of semisolids for pressure-assisted microsyringes-based printing is less demanding compared to fused filament fabrication.