Chapter 17
Lamellarins: A Tribe of Bioactive Marine Natural Products
Christian Bailly,
Christian Bailly
Institut de Recherche Pierre Fabre, Centre de Recherche et Développement, 3 Avenue Hubert Curien - BP 13562, 31035, Toulouse, Cedex 1, Francexd
Search for more papers by this authorChristian Bailly,
Christian Bailly
Institut de Recherche Pierre Fabre, Centre de Recherche et Développement, 3 Avenue Hubert Curien - BP 13562, 31035, Toulouse, Cedex 1, Francexd
Search for more papers by this authorBook Editor(s):Stéphane La Barre,
Jean-Michel Kornprobst,
Stéphane La Barre
Sorbonne Universités, UPMC Univ Paris 06, UMR 8227, Integrative Biology of Marine Models, Station Biologique de Roscoff, CS 90074, F-29688 Roscoff cedex, France
CNRS, UMR 8227, Integrative Biology of Marine Models, Station Biologique de Roscoff, CS 90074, F-29688 Roscoff cedex, France
Search for more papers by this authorJean-Michel Kornprobst
Institut Mer et Littoral,Bâtiment Isomer, 2, rue de la Houssinière, 44322 Nantes, BP 92208,Cedex 3, France
Search for more papers by this authorSummary
The first lamellarins were isolated from a small oceanic sea snail in 1985. Today, more than 70 lamellarins have been identified, and numerous derivatives synthesized and tested as antiviral or anticancer agents. The lead compound in the family is lamellarin D, characterized as a potent inhibitor of nuclear topoisomerase I, but also capable of directly interfering with mitochondria to trigger cancer cell death. In this chapter the biology and chemistry of lamellarins are discussed. Lamellarins can serve as a starting point for the design of anticancer or antiviral compounds. Extensive efforts have been devoted to the creation of novel structures, and to improve synthetic methods leading to lamellarins and related pyrrole-derived marine alkaloids.
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