Chapter 11
Cluster Headache and Other Trigemino-Autonomic Cephalgias
S. Evers, J. Áfra, A. Frese,
P. J. Goadsby,
M. Linde,
A. May, P. S. Sándor,
A. Frese
University of Münster, Germany
Academy of Manual Medicine, Münster, Germany
Search for more papers by this authorP. J. Goadsby
University of California, San Francisco, CA, USA
UCL, Institute of Neurology, Queen Square, London, UK
Search for more papers by this authorM. Linde
Cephalea Headache Centre, Läkarhuset Södra vägen, Gothenburg, Sweden
Search for more papers by this authorS. Evers, J. Áfra, A. Frese,
P. J. Goadsby,
M. Linde,
A. May, P. S. Sándor,
A. Frese
University of Münster, Germany
Academy of Manual Medicine, Münster, Germany
Search for more papers by this authorP. J. Goadsby
University of California, San Francisco, CA, USA
UCL, Institute of Neurology, Queen Square, London, UK
Search for more papers by this authorM. Linde
Cephalea Headache Centre, Läkarhuset Södra vägen, Gothenburg, Sweden
Search for more papers by this authorNils Erik Gilhus MD, PhD,
Michael P. Barnes MD, FRCP,
Michael Brainin MD,
Nils Erik Gilhus MD, PhD
Professor
Department of Clinical Medicine, University of Bergen and Department of Neurology, Haukeland University Hospital, Bergen, Norway
Search for more papers by this authorMichael P. Barnes MD, FRCP
Professor of Neurological Rehabilitation Medical Director
University of Newcastle, Hunters Moor Neurorehabilitation Ltd, Newcastle upon Tyne, UK
Search for more papers by this authorMichael Brainin MD
Professor
Department of Clinical Medicine and Prevention, and Center for Clinical Neurosciences, Donau-Universität Krems, Department of Neurology, Landesklinikum Donauregion Tulln Tulln, Austria
Search for more papers by this authorBook Author(s):Nils Erik Gilhus MD, PhD,
Michael P. Barnes MD, FRCP,
Michael Brainin MD,
Nils Erik Gilhus MD, PhD
Professor
Department of Clinical Medicine, University of Bergen and Department of Neurology, Haukeland University Hospital, Bergen, Norway
Search for more papers by this authorMichael P. Barnes MD, FRCP
Professor of Neurological Rehabilitation Medical Director
University of Newcastle, Hunters Moor Neurorehabilitation Ltd, Newcastle upon Tyne, UK
Search for more papers by this authorMichael Brainin MD
Professor
Department of Clinical Medicine and Prevention, and Center for Clinical Neurosciences, Donau-Universität Krems, Department of Neurology, Landesklinikum Donauregion Tulln Tulln, Austria
Search for more papers by this authorSummary
This chapter contains sections titled:
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Objectives
-
Background
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Search strategy
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Method for reaching consensus
-
Clinical syndromes
-
Treatment of cluster headache
-
Treatment of paroxysmal hemicrania
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Treatment of SUNCT syndrome
-
References
References
- Headache Classification Committee of the International Headache Society. The international classification of head-ache disorders, 2nd edition. Cephalalgia 2004; 24 (Suppl. 1): 1–160.
- Sjaastad O. Cluster Headache Syndrome. London: WB Saunders, 1992.
- Goadsby PJ. Short-lasting primary headaches: focus on trigeminal automatic cephalgias and indomethacin-sensitive headaches. Curr Opin Neurol 1999; 12: 273–7.
- May A. Headaches with (ipsilateral) autonomic symptoms. J Neurol 2003; 250: 1273–8.
- Brainin M, Barnes M, Baron JC, et al. Guidance for the preparation of neurological management guidelines by EFNS scientific task forces–revised recommendations 2004. Eur J Neurol 2004; 11: 577–81.
- Olesen J, Goadsby PJ, Ramadan NM, Tfelt-Hansen P, Welch KMA (eds) The Headaches, 3rd edn. Philadelphia: Lippincott, Williams & Wilkins, 2006.
- May A, Evers S, Straube A, Pfaffenrath V, Diener HC. Therapie und Prophylaxe von Clusterkopfschmerzen und anderen trigemino-autonomen Kopfschmerzen. Nervenheilkunde 2004; 23: 478–90.
- Tonon C, Guttmann S, Volpini M, Naccarato S, Cortelli P, D'Alessandro R. Prevalence and incidence of cluster headache in the Republic of San Marino. Neurology 2002; 58: 1407–9.
- Sjaastad O, Bakketeig LS. Cluster headache prevalence. Vaga study of headache epidemiology. Cephalalgia 2003; 23: 528–33.
- Bahra A, May A, Goadsby PJ. Cluster headache: a prospective clinical study with diagnostic implications. Neurology 2002; 58: 354–61.
- Ekbom K, Svensson DA, Traff H, Waldenlind E. Age at onset and sex ratio in cluster headache: observations over three decades. Cephalalgia 2002; 22: 94–100.
- Manzoni GC. Gender ratio of cluster headache over the years: a possible role of changes in lifestyle. Cephalalgia 1998; 18: 138–42.
- Russell MB. Epidemiology and genetics of cluster headache. Lancet Neurol 2004; 3: 279–83.
- Sjaastd O, Dale I. Evidence for a new (?) treatable headache entity. Headache 1974; 14: 105–8.
- Dodick DW. Indomethacin-responsive headache syndromes. Curr Pain Headache Rep 2004; 8: 19–26.
- Blankenburg M, Hechler T, Dubbel G, Wamsler C, Zernikow B. Paroxysmal hemicrania in children-symptoms, diagnostic criteria, therapy and outcome. Cephalalgia 2009; 29: 873–82.
- Sjaastad O, Saunte C, Salvesen R, et al. Shortlasting, unilateral neuralgiform headache attacks with conjunctival injection, tearing, sweating, and rhinorrhea. Cephalalgia 1989; 19: 147–56.
- Matharu MS, Cohen AS, Boes CJ, Goadsby PJ. Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing syndrome: a review. Curr Pain Headache Rep 2003; 7: 308–18.
- May A, Leone M. Update on cluster headache. Curr Opin Neurol 2003; 16: 333–40.
- Matharu MS, Boes CJ, Goadsby PJ. Management of trigeminal autonomic cephalgias and hemicrania continua. Drugs 2003; 63: 1637–77.
- Nilsson Remahl AI, Laudon Meyer E, Cordonnier C, Goadsby PJ. Placebo response in cluster headache trials: a review. Cephalalgia 2003; 23: 504–10.
- Horton BT. Histaminic cephalgia: differential diagnosis and treatment. Mayo Clin Proc 1956; 31: 325–33.
- Kudrow L. Response of cluster headache to oxygen inhalation. Headache 1981; 21: 1–4.
- Fogan L. Treatment of cluster headache. A double-blind comparison of oxygen v air inhalation. Arch Neurol 1985; 42: 362–3.
- Ekbom K. Treatment of cluster headache: clinical trials, design and results. Cephalalgia 1995; 15: 33–6.
- Gallagher RM, Mueller L, Ciervo CA. Analgesic use in cluster headache. Headache 1996; 36: 105–7.
- Ekbom K, Monstad I, Prusinski A, Cole JA, Pilgrim AJ, Noronha D. Subcutaneous sumatriptan in the acute treatment of cluster headache: a dose comparison study. The Sumatriptan Cluster Headache Study Group. Acta Neurol Scand 1993; 88: 63–9.
- Kuhn J, Vosskaemper M, Bewermeyer H. SUNCT syndrome: a possible bilateral case responding to topiramate. Neurology 2005; 64: 2159.
- The Sumatriptan Cluster Headache Study Group. Treatment of acute cluster headache with sumatriptan. N Engl J Med 1991; 325: 322–6.
- Ekbom K, Krabbe A, Micieli G, et al. Cluster headache attacks treated for up to three months with subcutaneous sumatriptan (6 mg). Sumatriptan Cluster Headache Long-term Study Group. Cephalalgia 1995; 15: 230–6.
- Göbel H, Lindner V, Heinze A, Ribbat M, Peuschl G. Acute therapy for cluster headache with sumatriptan: findings of a one-year long-term study. Neurology 1998; 51: 908–11.
-
Krabbe A. Early clinical experience with GR43175 in acute cluster headache attacks. Cephalalgia 1989; 9 (Suppl. 10): 404–5.
10.1177/0333102489009S10214 Google Scholar
- Gregor N, Schlesiger C, Akova-Oztürk E, Kraemer C, Husstedt IW, Evers S. Treatment of cluster headache attacks with less than 6 mg subcutaneous sumatriptan. Headache 2005; 45: 1069–72.
- Rapoport AM, Mathew NT, Silberstein SD, et al. Zolmitriptan nasal spray in the acute treatment of cluster headache: a double-blind study. Neurology 2007; 69: 821–6.
- Cittadini E, May A, Straube A, Evers S, Bussone G, Goadsby PJ. Effectiveness of intranasal zolmitriptan in acute cluster headache: a randomized, placebo-controlled, double-blind crossover study. Arch Neurol 2006; 63: 1537–42.
- Schuh-Hofer S, Reuter U, Kinze S, Einhaupl KM, Arnold G. Treatment of acute cluster headache with 20 mg sumatriptan nasal spray–an open pilot study. J Neurol 2002; 249: 94–9.
- Van Vliet JA, Bahra A, Martin V, et al. Intranasal sumatriptan in cluster headache: randomized placebo-controlled double-blind study. Neurology 2003; 60: 630–3.
- Bahra A, Gawel MJ, Hardebo JE, Millson D, Breen SA, Goadsby PJ. Oral zolmitriptan is effective in the acute treatment of cluster headache. Neurology 2000; 54: 1832–9.
- Horton BT, Ryan R, Reynolds JL. Clinical observations of the use of E.C. 110, a new agent for the treatment of headache. Mayo Clin Proc 1948; 23: 104–8.
- Kunkle EC, Pfeiffer JB, Wilhoit WM, Hamrick LW. Recurrent brief attacks in cluster pattern. Trans Am Neurol Assoc 1952; 77: 240–3.
- Friedman AP, Mikropoulos HE. Cluster headaches. Neurology 1958; 8: 653–63.
- Speed WG. Ergotamine tartrate inhalation: a new approach for the management of recurrent vascular headaches. Am J Med Sci 1960; 240: 327–31.
- Graham JR, Malvea BP, Gramm HF. Aerosol ergotamine tartrate for migraine and Horton's syndrome. N Engl J Med 1960; 263: 802–4.
- Duvoisin RC, Parker GW, Kenoyer WL. The cluster headache. Arch Intern Med 1961; 108: 711–6.
- Ekbom K, Krabbe AE, Paalzow G, Paalzow L, Tfelt-Hansen P, Waldenlind E. Optimal routes of administration of ergotamine tartrate in cluster headache patients. A pharmacokinetic study. Cephalalgia 1983; 3: 15–20.
- Andersson PG, Jespersen LT. Dihydroergotamine nasal spray in the treatment of attacks of cluster headache. Cephalalgia 1986; 6: 51–4.
- Magnoux E, Zlotnik G. Outpatient intravenous dihydroergotamine for refractory cluster headache. Headache 2004; 44: 249–55.
- Horton BT. Histaminic cephalgia. Lancet 1952; ii: 92–8.
- Schiller F. Prophylatcic and other treatment for histaminic, cluster, or limited variant migraine. JAMA 1960; 173: 1907–11.
- Symonds C. A particular variety of headache. Brain 1956; 79: 217–32.
- Kittrelle JP, Grouse DS, Seybold ME. Cluster headache. Local anesthetic abortive agents. Arch Neurol 1985; 42: 496–8.
- Markley HG. Topical agents in the treatment of cluster headache. Curr Pain Headache Rep 2003; 7: 139–43.
- Mills TM, Scoggin JA. Intranasal lidocaine for migraine and cluster headaches. Ann Pharmacother 1997; 31: 914–5.
- Robbins L. Intranasal lidocaine for cluster headache. Headache 1995; 35: 83–4.
- Costa A, Pucci E, Antonaci F, et al. The effect of intranasal cocaine and lidocaine on nitroglycerin-induced attacks in cluster headache. Cephalalgia 2000; 20: 85–91.
- Matharu MS, Levy MJ, Meeran K, Goadsby PJ. Subcutaneous octreotide in cluster headache: randomized placebo-controlled double-blind crossover study. Ann Neurol 2004; 56: 488–94.
- Paemeleire K, Bahra A, Evers S, Matharu MS, Goadsby PJ. Medication-overuse headache in patients with cluster headache. Neurology 2006; 67: 109–13.
- Bussone G, Leone M, Peccarisi C, et al. Double blind comparison of lithium and verapamil in cluster headache prophylaxis. Headache 1990; 30: 411–7.
- Leone M, D'Amico D, Frediani F, et al. Verapamil in the prophylaxis of episodic cluster headache: a double-blind study versus placebo. Neurology 2000; 54: 1382–5.
- Gabai IJ, Spierings EL. Prophylactic treatment of cluster headache with verapamil. Headache 1989; 29: 167–8.
- Meyer JS, Nance M, Walker M, Zetusky WJ, Dowell RE. Migraine and cluster headache treatment with calcium antagonists supports a vascular pathogenesis. Headache 1985; 25: 358–67.
- De Carolis P, Baldrati A, Agati R, De Capoa D, D'Alessandro R, Sacquegna T. Nimodipine in episodic cluster headache: results and methodological considerations. Headache 1987; 27: 397–9.
- Ekbom K, Solomon S. Management of cluster headache. In: Olesen J, Tfelt-Hansen P, Welch KMA (eds) The Headaches. Philadelphia: Lippincott, 2000; pp. 731–40.
- Mir P, Alberca R, Navarro A, et al. Prophylactic treatment of episodic cluster headache with intravenous bolus of methylprednisolone. Neurol Sci 2003; 24: 318–24.
- Ekbom K. Lithium for cluster headache: review of the literature and preliminary results of long-term treatment. Headache 1981; 21: 132–9.
- Steiner TJ, Hering R, Couturier EGM, Davies PTG, Whitmarsh TE. Double-blind placebo-controlled trial of lithium in episodic cluster headache. Cephalalgia 1997; 17: 673–5.
- Manzoni GC, Bono C, Lanfranchi M, Micieli G, Terzano MG, Nappi G. Lithium carbonate in cluster headache: assessment of its short-and long-term therapeutic efficacy. Cephalalgia 1983; 3: 109–14.
- Ekbom K. Prophylactic treatment of cluster headache with a new serotonin antagonist, BC 105. Acta Neurol Scand 1969; 45: 601–10.
- Gallagher RM, Mueller LL, Freitag FG. Divalproex sodium in the treatment of migraine and cluster headaches. J Am Osteopath Assoc 2002; 102: 92–4.
- Hering R, Kuritzky A. Sodium valproate in the treatment of cluster headache: an open clinical trial. Cephalalgia 1989; 9: 195–8.
- El Amrani M, Massiou H, Bousser MG. A negative trial of sodium valproate in cluster headache: methodological issues. Cephalalgia 2002; 22: 205–8.
- Förderreuther S, Mayer M, Straube A. Treatment of cluster headache with topiramate: effects and side-effects in five patients. Cephalalgia 2002; 22: 186–9.
- Rozen TD. Antiepileptic drugs in the management of cluster headache and trigeminal neuralgia. Headache 2001; 41 (Suppl. 1): 25–33.
- McGeeney BE. Topiramate in the treatment of cluster headache. Curr Pain Headache Rep 2003; 7: 135–8.
- Schuh-Hofer S, Israel H, Neeb L, Reuter U, Arnold G. The use of gabapentin in chronic cluster headache patients refractory to first-line therapy. Eur J Neurol 2007; 14: 694–6.
- Monstad I, Krabbe A, Micieli G, et al. Pre-emptive oral treatment with sumatriptan during a cluster period. Headache 1995; 35: 607–13.
- Zebenholzer K, Wober C, Vigl M, Wessely P. Eletriptan for the short-term prophylaxis of cluster headache. Headache 2004; 44: 361–4.
- Mulder LJ, Spierings EL. Naratriptan in the preventive treatment of cluster headache. Cephalalgia 2002; 22: 815–7.
- Fusco BM, Marabini S, Maggi CA, Fiore G, Geppetti P. Preventative effect of repeated nasal applications of capsaicin in cluster headache. Pain 1994; 59: 321–5.
- Sicuteri F, Fusco BM, Marabini S, et al. Beneficial effect of capsaicin application to the nasal mucosa in cluster headache. Clin J Pain 1989; 5: 49–53.
- Marks DR, Rapoport A, Padla D, et al. A double-blind, placebo-controlled trial of intranasal capsaicin for cluster headache. Cephalalgia 1993; 13: 114–6.
- Saper JR, Klapper J, Mathew NT, Rapoport A, Phillips SB, Bernstein JE. Intranasal civamide for the treatment of episodic cluster headaches. Arch Neurol 2002; 59: 990–4.
- Leone M, D'Amico D, Moschiano F, Fraschini F, Bussone G. Melatonin versus placebo in the prophylaxis of cluster headache: a double-blind pilot study with parallel groups. Cephalalgia 1996; 16: 494–6.
- Pringsheim T, Magnoux E, Dobson CF, Hamel E, Aube M. Melatonin as adjunctive therapy in the prophylaxis of cluster headache: a pilot study. Headache 2002; 42: 787–92.
- Hering-Hanit R, Gadoth N. Baclofen in cluster headache. Headache 2000; 40: 48–51.
- Evers S. Botulinum toxin and the management of chronic headaches. Curr Opin Otolaryngol Nead Neck Surg 2004; 12: 197–203.
- Leone M, Attanasio A, Grazzi L, et al. Transdermal clonidine in the prophylaxis of episodic cluster headache: an open study. Headache 1997; 37: 559–60.
- Di Sabato F, Fusco BM, Pelaia P, Giacovazzo M. Hyperbaric oxygen therapy in cluster headache. Pain 1993; 52: 243–5.
- Nilsson Remahl AI, Ansjon R, Lind F, Waldenlind E. Hyperbaric oxygen treatment of active cluster headache: a double-blind placebo-controlled cross-over study. Cephalalgia 2002; 22: 730–9.
- Anthony M. Arrest of attacks of cluster headache by local steroid injection of the occipital nerve. In: Rose C (ed.) Migraine. Basel: Karger, 1985; pp. 169–73.
- Peres MF, Stiles MA, Siow HC, Rozen TD, Young WB, Silberstein SD. Greater occipital nerve blockade for cluster headache. Cephalalgia 2002; 22: 520–2.
- Busch V, Jakob W, Juergens T, Schulte-Mattler W, Kaube H, May A. Occipital nerve blockade in chronic cluster headache patients and functional connectivity between trigeminal and occipital nerves. Cephalalgia 2007; 27: 1206–14.
- Ambrosini A, Vandenheede M, Rossi P, et al. Suboccipital (GON) injection with long-acting steroids in cluster headache: a double-blind placebo-controlled study. Cephalalgia 2003; 23: 734.
- Ambrosini A, Vandenheede M, Rossi P, et al. Suboccipital injection with a mixture of rapid-and long-acting steroids in cluster headache: a double-blind placebo-controlled study. Pain 2005; 118: 92–6.
- Ekbom K, Lindgren L, Nilsson BY, Hardebo JE, Waldenlind E. Retro-Gasserian glycerol injection in the treatment of chronic cluster headache. Cephalalgia 1987; 7: 21–7.
- Taha JM, Tew JM Jr. Long-term results of radiofrequency rhizotomy in the treatment of cluster headache. Headache 1995; 35: 193–6.
- Ford RG, Ford KT, Swaid S, Young P, Jennelle R. Gamma knife treatment of refractory cluster headache. Headache 1998; 38: 3–9.
- Lovely TJ, Kotsiakis X, Jannetta PJ. The surgical management of chronic cluster headache. Headache 1998; 38: 590–4.
- Onofrio BM, Campbell JK. Surgical treatment of chronic cluster headache. Mayo Clin Proc 1986; 61: 537–44.
- Sanders M, Zuurmond WW. Efficacy of sphenopalatine ganglion blockade in 66 patients suffering from cluster headache: a 12-to 70-month follow-up evaluation. J Neurosurg 1997; 87: 876–80.
- Narouze S, Kapural L, Casanova J, Mekhail N. Sphenopalatine ganglion radiofrequency ablation for the management of chronic cluster headache. Headache 2009; 49: 571–7.
- Matharu MS, Goadsby PJ. Persistence of attacks of cluster headache after trigeminal nerve root section. Brain 2002; 125: 976–84.
- Black DF, Dodick DW. Two cases of medically and surgically intractable SUNCT: a reason for caution and an argument for a central mechanism. Cephalalgia 2002; 22: 201–4.
- Jarrar RG, Black DF, Dodick DW, Davis DH. Outcome of trigeminal nerve section in the treatment of chronic cluster headache. Neurology 2003; 60: 1360–2.
- Donnet A, Valade D, Regis J. Gamma knife treatment for refractory cluster headache: prospective open trial. J Neurol Neurosurg Psychiatry 2005; 76: 218–21.
- McClelland S 3rd, Tendulkar RD, Barnett GH, Neyman G, Suh JH. Long-term results of radiosurgery for refractory cluster headache. Neurosurgery 2006; 59: 1258–62.
- Franzini A, Ferroli P, Leone M, Broggi G. Stimulation of the posterior hypothalamus for treatment of chronic intractable cluster headaches: first reported series. Neurosurgery 2003; 52: 1095–101.
- Leone M, Franzini A, Bussone G. Stereotactic stimulation of posterior hypothalamic gray matter in a patient with intractable cluster headache. N Engl J Med 2001; 345: 1428–9.
- Schoenen J, Di Clemente L, Vandenheede M, et al. Hypothalamic stimulation in chronic cluster headache: a pilot study of efficacy and mode of action. Brain 2005; 128: 940–7.
- Starr PA, Barbaro NM, Raskin NH, Ostrem JL. Chronic stimulation of the posterior hypothalamic region for cluster headache: technique and 1-year results in four patients. J Neurosurg 2007; 106: 999–1005.
- Bartsch T, Pinsker MO, Rasche D, et al. Hypothalamic deep brain stimulation for cluster headache: experience from a new multicase series. Cephalalgia 2008; 28: 285–95.
- Leone M, Franzini, A, Broggi, G, Mea, E, Cecchini, AP, Bussone, G. Acute hypothalamic stimulation and ongoing cluster headache attacks. Neurology 2006; 67: 1844–5.
- Schwedt TJ, Dodick DW, Hentz J, Trentman TL, Zimmerman RS. Occipital nerve stimulation for chronic headache–long-term safety and efficacy. Cephalalgia 2007; 27: 153–7.
- Magis D, Allena M, Bolla M, De Pasqua V, Remacle JM, Schoenen J. Occipital nerve stimulation for drug-resistant chronic cluster headache: a prospective pilot study. Lancet Neurol 2007; 6: 314–21.
- Burns B, Watkins L, Goadsby PJ. Treatment of intractable chronic cluster headache by occipital nerve stimulation in 14 patients. Neurology 2009; 72: 341–5.
- Antonaci F, Sjaastad O. Chronic paroxysmal hemicrania(CPH): a review of its clinical manifestations. Headache 1989; 29: 648–56.
- Sjaastad O, Stovner LJ, Stolt Nielsen A, Antonaci F, Fredriksen TA. CPH and hemicrania continua: requirements of high indomethacin dosages–an ominous sign? Headache 1995; 35: 363–7.
- Evers S, Husstedt IW. Alternatives in drug treatment of chronic paroxysmal hemicrania. Headache 1996; 36: 429–32.
- Antonaci F, Pareja JA, Caminero AB, Sjaastad O. Chronic paroxysmal hemicrania and hemicrania continua. Parenteral indomethacin: the 'indotest. Headache 1998; 38: 122–8.
- Shabbir N, McAbee G. Adolescent chronic paroxysmal hemicrania responsive to verapamil monotherapy. Headache 1994; 34: 209–10.
- Warner JS, Wamil AW, McLean MJ. Acetazolamide for the treatment of chronic paroxysmal hemicrania. Headache 1994; 34: 597–9.
- Cohen AS, Goadsby PJ. Paroxysmal hemicrania responding to topiramate. J Neurol Neurosurg Psychiatry 2007; 78: 96–7.
- Camarda C, Camarda R, Monastero R. Chronic paroxysmal hemicrania and hemicrania continua responding to topiramate: two case reports. Clin Neurol Neurosurg 2008; 110: 88–91.
- Sjaastad O, Antonaci F. A piroxciam derivative partly effective in chronic paroxysmal hemicrania and hemicrania continua. Headache 1995; 35: 549–50.
- Dahlöf C. Subcutaneous sumatriptan does not abort attacks of chronic paroxysmal hemicrania (CPH). Headache 1993; 33: 201–2.
- Antonaci F, Pareja JA, Caminero AB, Sjaastad O. Chronic paroxysmal hemicrania and hemicrania continua: anaesthetic blockades of pericranial nerves. Funct Neurol 1997; 12: 11–5.
- Pareja JA, Kruszewski P, Sjaastad O. SUNCT syndrome: trials of drugs and anaesthetic blockades. Headache 1995; 35: 138–42.
- D'Andrea G, Granella F, Ghiotto N, Nappi G. Lamotrigine in the treatment of SUNCT syndrome. Neurology 2001; 57: 1723–5.
- Malik K, Rizvi S, Vaillancourt PD. The SUNCT syndrome: successfully treated with lamotrigine. Pain Med 2002; 3: 167–8.
- Chakravarty A, Mukherjee A. SUNCT syndrome responsive to lamotrigine: documentation of the first Indian case. Cephalalgia 2003; 23: 474–5.
- Hunt CH, Dodick DW, Bosch EP. SUNCT responsive to gabapentin. Headache 2002; 42: 525–6.
- Etemadifar M, Maghzi AH, Ghasemi M, Chitsaz A, Kaji Esfahani M. Efficacy of gabapentin in the treatment of SUNCT syndrome. Cephalalgia 2008; 28: 1339–42.
- Porta-Etessam J, Benito-Leon J, Martinez-Salio A, Berbel A. Gabapentin in the treatment of SUNCT syndrome. Headache 2002; 42: 523–4.
- Rossi P, Cesarino F, Faroni J, Malpezzi MG, Sandrini G, Nappi G. SUNCT syndrome successfully treated with topiramate: case reports. Cephalalgia 2003; 23: 998–1000.
- Dora B. SUNCT syndrome with dramatic response to oxcarbazepine. Cephalalgia 2006; 26: 1171–3.
- Narbone MC, Gangemi S, Abbate M. A case of SUNCT syndrome responsive to verapamil. Cephalalgia 2005; 25: 476–8.
- Matharu MS, Cohen AS, Goadsby PJ. SUNCT syndrome responsive to intravenous lidocaine. Cephalalgia 2004; 24: 985–92.
- De Lourdes Figuerola M, Bruera O, Pozzo MJ, Leston J. SUNCT syndrome responding absolutely to steroids in two cases with different etiologies. J Headache Pain 2009; 10: 55–7.
- Schwaag S, Frese A, Husstedt IW, Evers S. SUNCT syndrome: the first German case series. Cephalalgia 2003; 23: 398–400.
- Leone M, Franzini A, D'Andrea G, Broggi, G, Casucci G, Bussone G. Deep brain stimulation to relieve drug-resistant SUNCT. Ann Neurol 2005; 57: 924–7.
- Lyons MK, Dodick DW, Evidente VG. Responsiveness of short-lasting unilateral neuralgiform headache with conjunctival injection and tearing to hypothalamic deep brain stimulation. J Neurosurg 2009; 110: 279–81.
