Induction of Apoptosis in Liver Tumors
Markus Selzner MD
Department of Surgery, Multiorgan Transplant Program, Toronto General Hospital, Toronto, Ontario, Canada
Search for more papers by this authorPierre-Alain Clavien MD, Phd, FACS, FRCS
Professor Chairman
Department of Surgery, Swiss Hepato-Pancreato-Biliary and Transplantation Center, University Hospital Zurich, Zurich, Switzerland
Search for more papers by this authorMarkus Selzner MD
Department of Surgery, Multiorgan Transplant Program, Toronto General Hospital, Toronto, Ontario, Canada
Search for more papers by this authorPierre-Alain Clavien MD, Phd, FACS, FRCS
Professor Chairman
Department of Surgery, Swiss Hepato-Pancreato-Biliary and Transplantation Center, University Hospital Zurich, Zurich, Switzerland
Search for more papers by this authorPierre-Alain Clavien MD, Phd, FACS, FRCS
Professor Chairman
Department of Surgery, Swiss Hepato-Pancreato-Biliary and Transplantation Center, University Hospital Zurich, Zurich, Switzerland
Search for more papers by this authorStefan Breitenstein MD
Department of Surgery, Swiss Hepato-Pancreato-Biliary and Transplantation Center, University Hospital Zurich, Zurich, Switzerland
Search for more papers by this authorSummary
This chapter contains sections titled:
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Apoptosis
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Inhibition of the apoptotic pathway in cancer cells
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Necrosis
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Conclusion
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Strategies to induce a poptosis in tumor cells
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Self-assessment questions
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References
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Self-assessment answers
References
- Makin G, Hickman J. Apoptosis and cancer chemotherapy. Cell Tissue Res 2000; 301: 143–52.
- Budman D, Berry D, Cirrincione C, et al. Dose and dose intensity as determinants of outcome in the adjuvant treatment of breast cancer. J Natl Cancer Inst 1998; 90: 1205–11.
- Glücksmann A. Cell deaths in normal vertebrate develpment. Biol Rev 1951; 26: 59–86.
- Saunders J. Deaths in embryonic systems. Science 1966; 154: 604–12.
-
Kerr J. Shhrinkage necrosis: a distinct mode of cellular death. J Pathol 1971; 105: 13–20.
10.1002/path.1711050103 Google Scholar
- Reed J. Dysregulation of apoptosis in cancer. J Clin Oncol 2000; 17: 2941–53.
- Kanzler S, Galle PR. Apoptosis and the liver. Semin Cancer Biol 2000; 10: 173–84.
- Roy S. Caspases at the heart of the apoptotic cell death pathway. Chem Res Toxicol 2000; 13: 961–2.
- Kaufmann S, Gores G. Apoptosis in cancer: cause and cure. BioEssay 2000; 22: 1007–17.
- Ding H, Fisher D. Mechanisms of p53-mediated apoptosis. Crit Rev Oncogen 1998; 9: 83–98.
- Mott JL, Gores GJ. Piercing the armor of hepatobiliary cancer: Bcl-2 homology domain 3 (BH3) mimetics and cell death. Hepatology 2007; 46: 906–11.
- Selzner M, Bielawaska A, Morse M, et al. Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. Cancer Res 2001; 61: 1233–40.
- Dahm F, Bielawska A, Nocito A, et al. Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice. Br J Cancer 2008; 98: 98–105.
- LaCasse E, Baird S, Korneluk R, MacKenzie A. The inhibitors of apoptosis (IAPs) and their emerging role in cancer. Oncogene 1998; 17: 3247–59.
- Selzner M, Rüdiger H, Sindram D, et al. Mechanisms of ischemic injury are different in the steatotic and normal rat liver. Hepatology 2000; 32: 1280–8.
- Diao J, Garces R, Richardson CD. X protein of hepatitis B virus modulates cytokine and growth factor related signal transduction pathways during the course of viral infections and hepatocarcinogenesis. Cytokine Growth Factor Rev 2001; 12: 189–205.
- Chen GG, Lai PB, Chan PK, et al. Decreased expression of Bid in human hepatocellular carcinoma is related to hepatitis B virus X protein. Eur J Cancer 2001; 37: 1695–702.
- Li D, Chen X, Zhang W. The inhibition of apoptosis of hepatoma cells induced by HBx is mediated by up-regulation of survivin expression. J Huazhong Univ Sci Technolog Med Sci 2003; 23: 383–6.
- Kalra N, Kumar V. c-Fos is a mediator of the c-myc-induced apoptotic signaling in serum-deprived hepatoma cells via the p38 mitogen-activated protein kinase pathway. J Biol Chem 2004; 279: 25313–9.
- Ikeguchi M, Ueda T, Sakatani T, et al. Expression of survivin messenger RNA correlates with poor prognosis in patients with hepatocellular carcinoma. Diagn Mol Pathol 2002; 11: 33–40.
- Ogawa K, Yasumura S, Atarashi Y, et al. Sodium butyrate enhances Fas-mediated apoptosis of human hepatoma cells. J Hepatol 2004; 40: 278–84.
- Villunger A, Strasser A. Does death receptor signaling play a role in tumorgenesis and cancer therapy. Oncol Res 1998; 10: 541–50.
- Pitti R, Marsters S, Lawrence D, et al. Genomic amplifi cation of a decoy receptor for fas ligand in lung and colon cancer. Nature 1998; 396: 699–703.
- Joseph B, Ekedahl J, Sirzen F, et al. Differences in the expression of pro-caspase in small cell and non-small cell lung carcinoma. Biochem Biophys Res Comm 1999; 262: 381–7.
- Klohn P, Bitsch A, Neumann H. Mitochondrial permeability transition is altered in early stages of carcinogenesisof 2-acetylaminofl uorene. Carcinogenesis 1998; 19: 1185–90.
- Reed J. Bcl-2 family proteins. Oncogene 1998; 17: 3225–36.
- JäätteläM. Escaping cell death: survival proteins in cancer. Exp Cell Res 1999; 248: 30–43.
- Berghella A, Pellegrini P, Contasta I, et al. Bcl-2 and drugs used in the treatment of cancer: new strategies of biotherapie which should not be underestimated. Cancer Biother 1998; 13: 225–37.
- Soini Y, Virkajarvi N, Lehto V, Paako P. Hepatocellular carcinoma with high proliferation index and a low degree of apoptosis and necrosis. Br J Cancer 1996; 73: 1025–30.
- Terada T, Nakanuma Y. Expression of apoptosis, proliferating cell nuclear antigen, and apoptosis-related antigens (bcl-2, c-myc, Fas, Lewis(y) and p53 in human cholangiocarcinoma and hepatocellular carcinomas. Pathol Int 1996; 46: 764–70.
- Soengas M, Alacron R, Yoshida H, et al. Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science 1999; 284: 156–9.
- Asker C, Wiman K, Selivanova G. p53-induced apoptosis as a safeguard against cancer. Biochem Biophys Res Comm 1999; 265: 1–6.
- Farazi PA, Glickman J, Horner J, Depinho RA. Cooperative interactions of p53 mutation, telomere dysfunction, and chronic liver damage in hepatocellular carcinoma progression. Cancer Res 2006; 66: 4766–73.
- Ito T, Shiraki K, Sugimoto K, et al. Survivin promotes cell proliferation in human hepatocellular carcinoma. Hepatology 2000; 31: 1080–5.
- Kaufmann S, Earnshaw W. Induction of apoptosis by cancer chemotherapy. Exp Cell Res 2000; 256: 42–9.
- Hieber U, Heim M. Tumor necrosis factor for the treatment of malignancies. Oncology 1994; 51: 142–53.
- Ogasawara J, Watanabe-Fukunaga R, Adachi A, et al. Lethal effect of the anti-Fas antibody in mice. Nature 1993; 364: 806–9.
- Cotter F. Antisense therapy of hematologic malignanvies. Semin Hematol 1999; 36: 9–14.
- Ambrosini G, Adida C, Sirugo G, Altieri D. Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting. J Biol Chem 1998; 273: 11177–82.
- Dindo D, Dahm F, Szulc Z, et al. Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells. Mol Cancer Ther 2006; 5: 1520–9.
- Di Paola M, Cocco T, Lorusso M. Ceramide interaction with the respiratory chain of heart mitochondria. Biochemistry 2000; 39: 6660–8.
- Modrak DE, Gold DV, Goldenberg DM. Sphingolipid targets in cancer therapy. Mol Cancer Ther 2006; 5: 200–8.
- Ruvolo PP, Deng X, Ito T, et al. Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A. J Biol Chem 1999; 274: 20296–300.
- Colell A, Garcia-Ruiz C, Mari M, Fernandez-Checa JC. Mitochondrial permeability transition induced by reactive oxygen species is independent of cholesterol-regulated membrane fl uidity. FEBS Lett 2004; 560: 63–8.