Chapter 14

Basophils: Biological Properties and Role in Allergic Diseases

Gianni Marone

Gianni Marone

Division of Clinical Immunology and Allergy, Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, School of Medicine, Naples, Italy

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Giuseppe Spadaro

Giuseppe Spadaro

Associate Professor of Medicine

Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy

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Arturo Genovese

Arturo Genovese

Professor of Medicine

Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy

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First published: 25 July 2008

Summary

This chapter contains sections titled:

  • Introduction

  • Origin of human basophils

  • Morphologic and ultrastructural characteristics of human basophils

  • Mediators of human basophils

  • Surface markers of human basophils

  • Evidence of basophil involvement in bronchial asthma

  • Basophil recruitment to allergic airways

  • Superallergens in allergic disorders

  • Role of basophils in allergic angiogenesis

  • Pharmacologic modulation of human basophils

  • Conclusions and implications

  • Acknowledgments

  • References

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