Standard Article
Actinides in Medicine
Eva R. Birnbaum,
Michael E. Fassbender,
Maryline G. Ferrier,
Kevin D. John,
Tara Mastren,
Eva R. Birnbaum
Los Alamos National Laboratory, Los Alamos, NM, USA
Search for more papers by this authorMichael E. Fassbender
Los Alamos National Laboratory, Los Alamos, NM, USA
Search for more papers by this authorMaryline G. Ferrier
Los Alamos National Laboratory, Los Alamos, NM, USA
Search for more papers by this authorKevin D. John
Los Alamos National Laboratory, Los Alamos, NM, USA
Search for more papers by this authorTara Mastren
Los Alamos National Laboratory, Los Alamos, NM, USA
Search for more papers by this authorEva R. Birnbaum,
Michael E. Fassbender,
Maryline G. Ferrier,
Kevin D. John,
Tara Mastren,
Eva R. Birnbaum
Los Alamos National Laboratory, Los Alamos, NM, USA
Search for more papers by this authorMichael E. Fassbender
Los Alamos National Laboratory, Los Alamos, NM, USA
Search for more papers by this authorMaryline G. Ferrier
Los Alamos National Laboratory, Los Alamos, NM, USA
Search for more papers by this authorKevin D. John
Los Alamos National Laboratory, Los Alamos, NM, USA
Search for more papers by this authorTara Mastren
Los Alamos National Laboratory, Los Alamos, NM, USA
Search for more papers by this authorAbstract
A summary of actinides and their past, present, and future applications in medicine is provided herein. Details associated with the role that actinides play in medical imaging and therapy is captured along with modes of production, medically relevant decay chains, principles of chelation, and target vectoring. Summaries of preclinical and clinical studies with specific emphasis on the field of targeted α therapy are also provided for Ac-225, Th-227, U-230, Th-226, and Bi-213 (daughter of Ac-225).
References
- 1N. I. Subcommittee, ‘ Meeting Isotope Needs and Capturing Opportunities for the Future: The 2015 Long Range Plan for the DOE-NP Isotope Program’, July 2015, pp. 48–49.
- 2F. F. Knapp and A. Dash, ‘ Radiopharmaceuticals for Therapy’, Springer, New Delhi, India, 2016.
10.1007/978-81-322-2607-9 Google Scholar
- 3R. F. Mould, ‘ A Century of X-rays and Radioactivity in Medicine: With Emphasis on Photographic Records of the Early Years’, Taylor & Francis, London, UK, 1993.
- 4G. M. MacKee, ‘ X-rays and Radium in the Treatment of Diseases of the Skin’, Lea & Febiger, Philadelphia, 1921.
- 5B. C. Reed, ‘ The History and Science of the Manhattan Project’, Springer, Berlin, Heidelberg, 2014, p. 15.
- 6J. E. Williams, J. Nucl. Med., 1999, 40, 16N.
- 7G. E. Birkett, ‘ Radium Therapy: Principles and Practice’, Cassell, London, 1931.
- 8R. F. Mould, Brit. J. Radiol., 1998, 71, 1229.
- 9L. Scerri and B. R. Allen, Int. J. Dermatol., 1996, 35, 142.
- 10S. M. Seidlin, L. D. Marinelli and E. Oshry, J. Am. Med. Assoc., 1946, 132, 838.
- 11 R. P. Baum ed., ‘ Therapeutic Nuclear Medicine’, Springer, Berlin, Heidelberg, 2014.
- 12W. G. Bradley, Proc. Am. Philos. Soc., 2008, 152, 349.
- 13W. D. Ehmann and D. E. Vance, ‘ Radiochemistry and Nuclear Methods of Analysis’, John Wiley & Sons, New York, NY, 1991, Vol. 116.
- 14G. Friedlander, J. W. Kennedy, E. S. Macias and J. M. Miller, ‘ Nuclear and Radiochemistry’, 3rd edition, John Wiley & Sons, New York, 1981.
- 15W. D. Loveland, D. J. Morrissey and G. T. Seaborg, ‘ Modern Nuclear Chemistry’, John Wiley & Sons, Hoboken, NJ, 2006, p. 671.
- 16Brookhaven National Laboratory, National Nuclear Data Center, 1994; https://www.nndc.bnl.gov/chart (accessed 30 Mar 2018).
- 17J. P. Pouget, I. Navarro-Teulon, M. Bardies, N. Chouin, G. Cartron, A. Pelegrin and D. Azria, Nat. Rev. Clin. Oncol., 2011, 8, 720.
- 18K. Schwochau, ‘ Technetium: : Chemistry and Radiopharmaceutical Applications’, Wiley-VCH Verlag GmbH, Weinheim (Federal Republic of Germany), 2007, p. 371.
- 19S. Noel, S. Cadet, E. Gras and C. Hureau, Chem. Soc. Rev., 2013, 42, 7747.
- 20C. M. Gomes, A. J. Abrunhosa, P. Ramos and E. K. J. Pauwels, Adv. Drug Deliv. Rev., 2011, 63, 547.
- 21M. E. Phelps, ‘ PET: Molecular Imaging and Its Biological Applications’, Springer-Verlag, New York, NY, 2004.
10.1007/978-0-387-22529-6 Google Scholar
- 22S. L. Pimlott and A. Sutherland, Chem. Soc. Rev., 2011, 40, 149.
- 23M. Durante and J. S. Loeffler, Nat. Rev. Clin. Oncol., 2010, 7, 37.
- 24D. Ash, E. Briot, A. Gerbaulet, C. Haie-Meder, E. Lartigau, J.-J. Mazeron, H. Meertens, R. Potter, P. Scalliet, E. Van Limbergen, J. Venselaar and A. Wambersie, ‘ The GEC ESTRO Handbook of Brachytherapy’, ESTRO, Brussels, Belgium, 2002, p. 678.
- 25A. I. Kassis and S. J. Adelstein, J. Nucl. Med., 2005, 46, 4S.
- 26Y. Dekempeneer, M. Keyaerts, A. Krasniqi, J. Puttemans, S. Muyldermans, T. Lahoutte, M. D'Huyvetter and N. Devoogdt, Exp. Opin. Biol. Ther., 2016, 16, 1035.
- 27S. Sofou, Int. J. Nanomed., 2008, 3, 181.
- 28 Committee on State of the Science of Nuclear Medicine, NRC, ‘ Advancing Nuclear Medicine Through Innovation’, The National Academies Press, Washington, DC, 2007, p. 176.
- 29J. Elgqvist, S. Frost, J. P. Pouget and P. Albertsson, Front. Oncol., 2014, 3, 324/321.
- 30F. Danhier, O. Feron and V. Preat, J. Control. Release, 2010, 148, 135.
- 31M. Jamous, U. Haberkorn and W. Mier, Molecules, 2013, 18, 3379.
- 32C. Kratochwil, F. L. Giesel, M. Stefanova, M. Benesova, M. Bronzel, A. Afshar-Oromieh, W. Mier, M. Eder, K. Kopka and U. Haberkorn, J. Nucl. Med., 2016, 57, 1170.
- 33C. H. Yeong, M. H. Cheng and K. H. Ng, J. Zhejiang Univ. Sci. B (Biomed. Biotechnol.), 2014, 15, 845.
10.1631/jzus.B1400131 Google Scholar
- 34S. M. Larson, J. A. Carrasquillo, N.-K. V. Cheung and O. W. Press, Nat. Rev. Cancer, 2015, 15, 347.
- 35M. Fani, H. R. Maecke and S. M. Okarvi, Theranostics, 2012, 2, 481.
- 36D. S. Wilbur, Curr. Radiopharmaceut., 2011, 4, 214.
- 37E. W. Price and C. Orvig, Chem. Soc. Rev., 2014, 43, 260.
- 38C. Kratochwil, F. Bruchertseifer, F. L. Giesel, M. Weis, F. A. Verburg, F. Mottaghy, K. Kopka, C. Apostolidis, U. Haberkorn and A. Morgenstern, J. Nucl. Med., 2016, 57, 1941.
- 39L. I. Guseva, Radiochemistry, 2014, 56, 451.
- 40S. Mirzadeh, L. F. Mausner and M. A. Garland, in ‘ Handbook of Nuclear Chemistry’, eds. A. Vértes, S. Nagy, Z. Klencsár, R. G. Lovas and F. Rösch, Springer US, Boston, MA, 2011, p. 1857.
- 41S. M. Qaim, in ‘ Handbook of Nuclear Chemistry’, eds. A. Vértes, S. Nagy, Z. Klencsár, R. G. Lovas and F. Rösch, Springer US, Boston, MA, 2011, p. 1903.
- 42J. W. Weidner, S. G. Mashnik, K. D. John, F. Hemez, B. Ballard, H. Bach, E. R. Birnbaum, L. J. Bitteker, A. Couture, D. Dry, M. E. Fassbender, M. S. Gulley, K. R. Jackman, J. L. Ullmann, L. E. Wolfsberg and F. M. Nortier, Appl. Radiat. Isot., 2012, 70, 2602.
- 43J. W. Weidner, S. G. Mashnik, K. D. John, B. Ballard, E. R. Birnbaum, L. J. Bitteker, A. Couture, M. E. Fassbender, G. S. Goff, R. Gritzo, F. M. Hemez, W. Runde, J. L. Ullmann, L. E. Wolfsberg and F. M. Nortier, Appl. Radiat. Isot., 2012, 70, 2590.
- 44V. Radchenko, J. W. Engle, J. J. Wilson, J. R. Maassen, M. F. Nortier, E. R. Birnbaum, K. D. John and M. E. Fassbender, Radiochim. Acta, 2016, 104, 291.
- 45E. P. Horwitz and A. H. Bond, Czech. J. Phys., 2003, 53, A713.
- 46F. Rösch and F. F. Knapp, in ‘ Handbook of Nuclear Chemistry’, eds. A. Vértes, S. Nagy, Z. Klencsár, R. G. Lovas and F. Rösch, Springer US, Boston, MA, 2011, p. 1935.
- 47J. R. Griswold, D. G. Medvedev, J. W. Engle, R. Copping, J. M. Fitzsimmons, V. Radchenko, J. C. Cooley, M. E. Fassbender, D. L. Denton, K. E. Murphy, A. C. Owens, E. R. Birnbaum, K. D. John, F. M. Nortier, D. W. Stracener, L. H. Heilbronn, L. F. Mausner and S. Mirzadeh, Appl. Radiat. Isot., 2016, 118, 366.
- 48A. A. Kotovskii, N. A. Nerozin, I. V. Prokof'ev, V. V. Shapovalov, Y. A. Yakovshchits, A. S. Bolonkin and A. V. Dunin, Radiochemistry, 2015, 57, 285.
- 49R. A. Boll, D. Malkemus and S. Mirzadeh, Appl. Radiat. Isot., 2005, 62, 667.
- 50M. Miederer, D. A. Scheinberg and M. R. McDevitt, Adv. Drug. Deliv. Rev., 2008, 60, 1371.
- 51G. Melville and B. J. Allen, Appl. Radiat. Isot., 2009, 67, 549.
- 52J. W. Engle, J. W. Weidner, B. D. Ballard, M. E. Fassbender, L. A. Hudston, K. R. Jackman, D. E. Dry, L. E. Wolfsberg, L. J. Bitteker, J. L. Ullmann, M. S. Gulley, C. Pillai, G. Goff, E. R. Birnbaum, K. D. John, S. G. Mashnik and F. M. Nortier, Radiochim. Acta, 2014, 569.
- 53M. R. McDevitt, D. Ma, J. Simon, R. K. Frank and D. A. Scheinberg, Appl. Radiat. Isot., 2002, 57, 841.
- 54M. L. Matson, C. H. Villa, J. S. Ananta, J. J. Law, D. A. Scheinberg and L. J. Wilson, J. Nucl. Med., 2015, 56, 897.
- 55G. Wang, R. M. de Kruijff, A. Rol, L. Thijssen, E. Mendes, A. Morgenstern, F. Bruchertseifer, M. C. Stuart, H. T. Wolterbeek and A. G. Denkova, Appl. Radiat. Isot., 2014, 85, 45.
- 56M.-Y. Chang, J. Seideman and S. Sofou, Bioconjugate Chem., 2008, 19, 1274.
- 57J. Fitzsimmons and R. Atcher, J. Label. Compd. Radiopharmaceut., 2007, 50, 147.
- 58R. M. de Kruijff, H. T. Wolterbeek and A. G. Denkova, Pharmaceuticals (Basel), 2015, 8, 321.
- 59K. A. Deal, I. A. Davis, S. Mirzadeh, S. J. Kennel and M. W. Brechbiel, J. Med. Chem., 1999, 42, 2988.
- 60I. A. Davis, K. A. Glowienka, R. A. Boll, K. A. Deal, M. W. Brechbiel, M. Stabin, P. N. Bochsler, S. Mirzadeh and S. J. Kennel, Nucl. Med. Biol., 1999, 26, 581.
- 61A. Sattiraju, K. K. S. Sai, A. Xuan, D. N. Pandya, F. G. Almaguel, T. J. Wadas, D. M. Herpai, W. Debinski and A. Mintz, Oncotarget, 2017, 8, 42997.
- 62D. N. Pandya, R. Hantgan, M. M. Budzevich, N. D. Kock, D. L. Morse, I. Batista, A. Mintz, K. C. Li and T. J. Wadas, Theranostics, 2016, 6, 698.
- 63J. Woodward, S. J. Kennel, A. Stuckey, D. Osborne, J. Wall, A. J. Rondinone, R. F. Standaert and S. Mirzadeh, Bioconjugate Chem., 2011, 22, 766.
- 64M. F. McLaughlin, J. Woodward, R. A. Boll, J. S. Wall, A. J. Rondinone, S. J. Kennel, S. Mirzadeh and J. D. Robertson, PLoS One, 2013, 8, e54531.
- 65M. Essler, F. C. Gartner, F. Neff, B. Blechert, R. Senekowitsch-Schmidtke, F. Bruchertseifer, A. Morgenstern and C. Seidl, Eur. J. Nucl. Med. Mol. Imaging, 2012, 39, 602.
- 66F. E. Escorcia, E. Henke, M. R. McDevitt, C. H. Villa, P. Smith-Jones, R. G. Blasberg, R. Benezra and D. A. Scheinberg, Cancer Res., 2010, 70, 9277.
- 67H. Song, R. F. Hobbs, R. Vajravelu, D. L. Huso, C. Esaias, C. Apostolidis, A. Morgenstern and G. Sgouros, Cancer Res., 2009, 69, 8941.
- 68M. Miederer, G. Henriksen, A. Alke, I. Mossbrugger, L. Quintanilla-Martinez, R. Senekowitsch-Schmidtke and M. Essler, Clin. Cancer Res., 2008, 14, 3555.
- 69M. Miederer, M. R. McDevitt, P. Borchardt, I. Bergman, K. Kramer, N. K. Cheung and D. A. Scheinberg, Clin. Cancer Res., 2004, 10, 6985.
- 70M. Miederer, M. R. McDevitt, G. Sgouros, K. Kramer, N. K. Cheung and D. A. Scheinberg, J. Nucl. Med., 2004, 45, 129.
- 71P. E. Borchardt, R. R. Yuan, M. Miederer, M. R. McDevitt and D. A. Scheinberg, Cancer Res., 2003, 63, 5084.
- 72S. J. Kennel, L. L. Chappell, K. Dadachova, M. W. Brechbiel, T. K. Lankford, I. A. Davis, M. Stabin and S. Mirzadeh, Cancer Biother. Radio., 2004, 15, 235.
- 73F. M. Kaspersen, E. Bos, A. V. Doornmalen, M. W. Geerlings, C. Apostolidis and R. Molinet, Nucl. Med. Commun., 1995, 16, 468.
- 74J. G. Jurcic, T. L. Rosenblat, M. R. McDevitt, N. Pandit-Taskar, J. A. Carrasquillo, S. M. Chanel, C. Ryan, M. G. Frattini, D. Cicic, S. M. Larson and D. A. Scheinberg, J. Clin. Oncol., 2011, 29, 6516.
- 75J. G. Jurcic, M. Levy, J. Park, F. Ravandi, A. Perl, J. Pagel, B. Smith, J. Orozco, E. Estey, H. Kantarjian, D. Cicic and D. A. Scheinberg, J. Nucl. Med., 2017, 58, 456.
- 76M. G. Ferrier, E. R. Batista, J. M. Berg, E. R. Birnbaum, J. N. Cross, J. W. Engle, H. S. La Pierre, S. A. Kozimor, J. S. Lezama Pacheco, B. W. Stein, S. C. Stieber and J. J. Wilson, Nat. Commun., 2016, 7, 12312.
- 77M. G. Ferrier, B. W. Stein, E. R. Batista, J. M. Berg, E. R. Birnbaum, J. W. Engle, K. D. John, S. A. Kozimor, J. S. Lezama Pacheco and L. N. Redman, ACS Central Sci., 2017, 3, 176.
- 78R. D. Shannon, Acta Crystallogr., 1976, A32, 751.
- 79G. Sgouros, A. M. Ballangrud, J. G. Jurcic, M. R. McDevitt, J. L. Humm, Y. E. Erdi, B. M. Mehta, R. D. Finn, S. M. Larson and D. A. Scheinberg, J. Nucl. Med., 1999, 40, 1935.
- 80M. R. McDevitt, R. D. Finn, G. Sgouros, D. Ma and D. A. Scheinberg, Appl. Radiat. Isot., 1999, 50, 895.
- 81L. Dorso, E. Bigot-Corbel, J. Abadie, M. Diab, S. Gouard, F. Bruchertseifer, A. Morgenstern, C. Maurel, M. Cherel and F. Davodeau, PLoS One, 2016, 11, e0151330.
- 82O. Couturier, S. Supiot, M. Degraef-Mougin, A. Faivre-Chauvet, T. Carlier, J. F. Chatal, F. Davodeau and M. Cherel, Eur. J. Nucl. Med. Mol. Imaging, 2005, 32, 601.
- 83Y. S. Kim and M. W. Brechbiel, Tumour Biol., 2012, 33, 573.
- 84A. Morgenstern, F. Bruchertseifer and C. Apostolidis, Curr. Radiopharmaceut., 2012, 5, 221.
- 85M. W. Brechbiel, Dalton Trans., 2007, 43, 4918.
- 86T. L. Rosenblat, M. R. McDevitt, D. A. Mulford, N. Pandit-Taskar, C. R. Divgi, K. S. Panageas, M. L. Heaney, S. Chanel, A. Morgenstern, G. Sgouros, S. M. Larson, D. A. Scheinberg and J. G. Jurcic, Clin. Cancer Res., 2010, 16, 5303.
- 87J. G. Jurcic, S. M. Larson, G. Sgouros, M. R. McDevitt, R. D. Finn, C. R. Divgi, A. M. Ballangrud, K. A. Hamacher, D. Ma, J. L. Humm, M. W. Brechbiel, R. Molinet and D. A. Scheinberg, Blood, 2002, 100, 1233.
- 88B. J. Allen, A. A. Singla, S. M. Rizvi, P. Graham, F. Bruchertseifer, C. Apostolidis and A. Morgenstern, Immunotherapy, 2011, 3, 1041.
- 89D. Cordier, F. Forrer, F. Bruchertseifer, A. Morgenstern, C. Apostolidis, S. Good, J. Muller-Brand, H. Macke, J. C. Reubi and A. Merlo, Eur. J. Nucl. Med. Mol. Imaging, 2010, 37, 1335.
- 90C. Kratochwil, F. L. Giesel, F. Bruchertseifer, W. Mier, C. Apostolidis, R. Boll, K. Murphy, U. Haberkorn and A. Morgenstern, Eur. J. Nucl. Med. Mol. Imaging, 2014, 41, 2106.
- 91H. Song, K. Shahverdi, D. L. Huso, C. Esaias, J. Fox, A. Liedy, Z. Zhang, R. T. Reilly, C. Apostolidis, A. Morgenstern and G. Sgouros, Cancer Res., 2008, 68, 3873.
- 92Z. B. Alfassi, M. Bonardi, F. Groppi and E. Menapace, J. Radioanal. Nucl. Chem., 2006, 270, 483.
- 93C. Apostolidis, F. Bruchertseifer and A. F. Morgenstern, Eur. J. Nucl. Med. Mol. Imaging, 2005, 32, S87.
- 94M. R. Pillai, A. Dash and F. F. Knapp Jr J. Nucl. Med., 2013, 54, 313.
- 95F. Benard, K. R. Buckley, T. J. Ruth, S. K. Zeisler, J. Klug, V. Hanemaayer, M. Vuckovic, X. Hou, A. Celler, J. P. Appiah, J. Valliant, M. S. Kovacs and P. Schaffer, J. Nucl. Med., 2014, 55, 1017.
- 96G. E. Dale, D. A. Dalmas, M. J. Gallegos, K. R. Jackman, C. T. Kelsey, I. May, S. D. Reilly and G. M. Stange, Ind. Eng. Chem. Res., 2012, 51, 13319.
- 97A. Morgenstern, O. Lebeda, J. Stursa, F. Bruchertseifer, R. Capote, J. McGinley, G. Rasmussen, M. Sin, B. Zielinska and C. Apostolidis, Anal. Chem., 2008, 80, 8763.
- 98A. Morgenstern, C. Apostolidis, F. Bruchertseifer, R. Capote, T. Gouder, F. Simonelli, M. Sin and K. Abbas, Appl. Radiat. Isot., 2008, 66, 1275.
- 99C. Duchemin, A. Guertin, F. Haddad, N. Michel and V. Metivier, Nucl. Med. Biol., 2014, 41(Suppl), e19.
- 100G. Montavon, U. Repinc, C. Apostolidis, F. Bruchertseifer, K. Abbas and A. Morgenstern, Dalton Trans., 2010, 39, 1366.
- 101E. Kukleva, J. Kozempel, M. Vlk, P. Micolova and D. Vopalka, J. Radioanal. Nucl. Chem., 2015, 304, 263.
- 102J. Dahle, C. Krogh, K. B. Melhus, J. Borrebek, R. H. Larsen and Y. Kvinnsland, Int. J. Radiat. Oncol., 2009, 75, 886.
- 103H. Heyerdahl, N. Abbas, E. M. Brevik, C. Mollatt and J. Dahle, Plos One, 2012, 7, e42345.
- 104U. B. Hagemann, K. Wickstroem, E. Wang, A. O. Shea, K. Sponheim, J. Karlsson, R. M. Bjerke, O. B. Ryan and A. S. Cuthbertson, Mol. Cancer Ther., 2016, 15, 2422.
- 105H. Heyerdahl, C. Krogh, J. Borrebaek, A. Larsen and J. Dahle, Int. J. Radiat. Oncol., 2011, 79, 563.
- 106A. H. Staudacher, E. Bezak, A. Borysenko and M. P. Brown, Nucl. Med. Commun., 2014, 35, 1284.
- 107J. Dahle, T. J. Jonasdottir, H. Heyerdahl, J. M. Nesland, J. Borrebaek, A. K. Hjelmerud and R. H. Larsen, Eur. J. Nucl. Med. Mol. Imaging, 2010, 37, 93.
- 108K. B. Melhus, R. H. Larsen, T. Stokke, O. Kaalhus, P. K. Selbo and J. Dahle, Cancer Biother. Radio., 2007, 22, 469.
