Ventricular septal defects (VSDs) are the most common congenital heart disease (20% of cases). Muscular VSDs (MVSDs) account for 20% of interventricular septum defects, being the most common location in the apical portion of the muscular septum, followed by the mid-ventricular and the anterior in the right outflow tract. Many of these muscular defects can be closed percutaneously with self-expanding devices adapted to the ventricular anatomy. On the other hand, perimembranous VSDs (PMVSDs) are the most frequent, and although the proximity of the aortic valve makes them a challenge, the development of new devices has made percutaneous closure possible. In this chapter, we will review the devices used in this therapy, implant techniques, and possible complications, distinguishing the approach for MVSD and PMVSD.