Chapter 5
Geographic Distribution of the Peripheral T-cell Lymphomas
Global Epidemiology
Amulya Yellala,
Avyakta Kallam,
James O. Armitage,
Amulya Yellala
Division of Oncology-Hematology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA
Search for more papers by this authorAvyakta Kallam
Division of Oncology-Hematology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA
Search for more papers by this authorJames O. Armitage
Division of Oncology-Hematology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA
Search for more papers by this authorAmulya Yellala,
Avyakta Kallam,
James O. Armitage,
Amulya Yellala
Division of Oncology-Hematology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA
Search for more papers by this authorAvyakta Kallam
Division of Oncology-Hematology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA
Search for more papers by this authorJames O. Armitage
Division of Oncology-Hematology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA
Search for more papers by this authorBook Editor(s):Owen A. O'Connor M.D., Ph.D.,
Won Seog Kim,
Pier Luigi Zinzani M.D., Ph.D.,
Owen A. O'Connor M.D., Ph.D.
American Cancer Society Research Professor Professor of Medicine
Department of Medicine, Division of Hematology and Oncology, Program for T-Cell Lymphoma Research, Department of Microbiology, Immunology, and Cancer Research, University of Virginia Cancer Center, Charlottesville, VA, USA
Search for more papers by this authorWon Seog Kim
Sungkyunkwan University School of Medicine, Seoul, Korea
Search for more papers by this authorPier Luigi Zinzani M.D., Ph.D.
Professor of Hematology
Department of Medicine, Program for Lymphomas and Chronic Lymphocytic Leukemia, University of Bologna, Bologna, Italy
Search for more papers by this authorFirst published: 19 February 2021
Summary
The T-cell lymphomas are characterized by marked differences in its global patterns of distribution. The epidemiology and classification of non-Hodgkin lymphoma (NHL) has undergone vast transformation over the past few decades. In an attempt to study the geographical distribution of NHL subtypes, the International NHL Classification Project was conducted in the late 1990s. The 2017 WHO classification broadly divides peripheral T-cell lymphomas (PTCL) into three categories based on their location. They are leukemic (disseminated), nodal, and extranodal. These categories are further subdivided based on morphology, immunohistochemistry, and clinical behavior. Examples of these lymphomas include PTCL not otherwise specified (PTCL-NOS), angioimmunoblastic T-cell lymphomas, anaplastic large-cell lymphoma (ALCL), anaplastic lymphoma kinase positive (ALK+), ALK negative (ALK–) ALCL, intestinal T-cell lymphoma, and breast implant-associated ALCL. This chapter discusses the epidemiological data for each of the individual subtype of PTCL.
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