The sufferings from diseases spread by ectoparasites throughout the globe are making it a burning issue affecting human health individually and collectively. Insecticides rampantly being used against those ectoparasites are paving way for bigger problems like toxicity, resistance, residual concerns about their long-term effects on the environment, etc. Ancient records of usage of plants for medicinal purposes are documented in books like Rigveda, Ebers Papyrus, Bible, and so on. The pharmaco-active ingredients stored in root, leaves, seed, and bark of plants must be exploited. Researchers and medical experts are spearheading a paradigm shift to natural drugs from synthetic ones against serious ectoparasitic diseases. To this extent, the world is experiencing an increasing advocacy for exploration of phytochemicals from medicinal plants for cure and prevention of diseases like scabies and myiasis. These phytochemicals are safe, cheap, and are less susceptible to resistance. Their use can also facilitate the discovery of newer drug molecules for eradication of other ectoparasites like lice, tick, mites, etc., and alleviating diseases caused by them. These phytochemicals can serve as curative drugs in themselves or can be part of drug regimen prescribed for the prevention of scabies and myiasis. This chapter summarizes the role of phytochemicals in the treatment of scabies and human myiasis.