Chapter 2
Neglected Tropical Diseases, Phytochemicals, Protein Targets, and Mechanisms in Drug Discovery
Lalit R. Samant,
Tehseen M. Dhorajiwala,
Sumit T. Haldar,
Lalit R. Samant
Molecular Genetics Research Laboratory, Bai Jerbai Wadia Hospital for Children, Mumbai, Maharashtra, India
Search for more papers by this authorTehseen M. Dhorajiwala
Dhorajiwala, Freelance Bioinformatician, Thane, Maharashtra, India
Search for more papers by this authorSumit T. Haldar
Freelance Bioinformatician, Thane, Maharashtra, India
Search for more papers by this authorLalit R. Samant,
Tehseen M. Dhorajiwala,
Sumit T. Haldar,
Lalit R. Samant
Molecular Genetics Research Laboratory, Bai Jerbai Wadia Hospital for Children, Mumbai, Maharashtra, India
Search for more papers by this authorTehseen M. Dhorajiwala
Dhorajiwala, Freelance Bioinformatician, Thane, Maharashtra, India
Search for more papers by this authorSumit T. Haldar
Freelance Bioinformatician, Thane, Maharashtra, India
Search for more papers by this authorBook Editor(s):Chukwuebuka Egbuna,
Muhammad Akram,
Jonathan Chinenye Ifemeje,
Chukwuebuka Egbuna
Chukwuemeka Odumegwu Ojukwu University, Uli, Nigeria
Search for more papers by this authorMuhammad Akram
Government College University, Faisalabad, Pakistan
Search for more papers by this authorJonathan Chinenye Ifemeje
Chukwuemeka Odumegwu Ojukwu University, Uli, Nigeria
Search for more papers by this authorFirst published: 22 September 2021
Summary
Neglected tropical diseases (NTDs) affect more than one billion people across 149 countries, mostly targeting populations who live in poverty and lack proper sanitation. NTD infections are either transmitted by vectors or are acquired by coming in direct contact with the disease-causing parasitic agents. NTDs targeted in this review article are African trypanosomiasis, Buruli ulcer, Chagas disease, Chikungunya, Dengue, Leishmaniasis, Leprosy, Lymphatic filariasis, Mycetoma, Onchocerciasis, Rabies, Scabies, and Schistosomiasis. With the growing need for efficient and cheaper drugs, which can be retrieved from natural sources and have no or fewer side effects, this chapter focuses on the identification of such phytochemicals from plant extracts against NTDs. Above mentioned NTDs are discussed independently with a list of phytochemicals active against that NTD.
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