Nutritional intervention in the treatment of acute pancreatitis (AP) is a continually evolving topic. This chapter establishes why nutritional intervention is important in the treatment of AP. It explores when to initiate nutritional intervention in the treatment process for the management of AP. In order to address the question of how to feed patients with AP, the chapter encompasses mode of introduction (oral vs. enteral tube) and compares nasogastric versus nasojejunal routes of administration. Since it has been established that prolonged nil by mouth is to be avoided (if possible) in all cases of AP, the next issue at hand is what form of nutrition should administered. Patients who can eat do not require additional enteral nutrition via feeding tubes. Oral feeding can be progressively attempted once concern for gastric outlet obstruction has resolved, provided it does not result in pain, and provided that complications are under control.