Chapter 41
The Mitochondrial Exposome
Douglas I. Walker,
Kurt D. Pennell,
Dean P. Jones,
Douglas I. Walker
Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, GA, USA
Department of Civil and Environmental Engineering, Tufts University, Medford, MA, USA
HERCULES Exposome Research Center, Department of Environmental Health, Rollins School of Public Health, Atlanta, GA, USA
Search for more papers by this authorKurt D. Pennell
Department of Civil and Environmental Engineering, Tufts University, Medford, MA, USA
Search for more papers by this authorDean P. Jones
Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, GA, USA
HERCULES Exposome Research Center, Department of Environmental Health, Rollins School of Public Health, Atlanta, GA, USA
Search for more papers by this authorDouglas I. Walker,
Kurt D. Pennell,
Dean P. Jones,
Douglas I. Walker
Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, GA, USA
Department of Civil and Environmental Engineering, Tufts University, Medford, MA, USA
HERCULES Exposome Research Center, Department of Environmental Health, Rollins School of Public Health, Atlanta, GA, USA
Search for more papers by this authorKurt D. Pennell
Department of Civil and Environmental Engineering, Tufts University, Medford, MA, USA
Search for more papers by this authorDean P. Jones
Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, GA, USA
HERCULES Exposome Research Center, Department of Environmental Health, Rollins School of Public Health, Atlanta, GA, USA
Search for more papers by this authorBook Editor(s):Yvonne Will PhD, ATS Fellow,
James A. Dykens,
Yvonne Will PhD, ATS Fellow
Pfizer Drug Safety R&D, Groton, CT, USA
Search for more papers by this authorFirst published: 23 February 2018
Summary
The human exposome is typically defined in terms of systemic exposures, with the goal of developing tools and techniques for measuring exposures for an individual. Phenotyping of the mitochondrial exposome can be used for hazard identification by surveying populations for the occurrence of exposures, and prevalence can be used to prioritize toxicity. Mitochondria are recognized as secondary toxicological targets for many common environmental pollutants, including naturally occurring exogenous chemicals, environmental chemicals, and pharmaceuticals. High-throughput screening (HTS) assays for testing mitochondrial toxicity enable screening and prioritization of a large number of environmental pollutants. High-resolution metabolomics (HRM) of the mitochondria isolates was performed using liquid chromatography with high-resolution mass spectrometry (HRMS). Applying HRM to study isolated human mitochondria has the potential to provide new insight into the chemical burden arising from exposure to environmental chemicals and to identify potential toxicological targets.
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