9 Data Integration, Metabolic Networks and Systems Biology
Annual Plant Reviews book series, Volume 43: Biology of Plant Metabolomics
Henning Redestig,
Jedrzej Szymanski,
Masami Y. Hirai,
Joachim Selbig,
Lothar Willmitzer,
Zoran Nikoloski,
Kazuki Saito,
Henning Redestig
RIKEN Plant Science Center, Yokohama-shi, 17-2-2 Tsurumi-ku, Suehiro-cho, 230-0045 Japan
Search for more papers by this authorJedrzej Szymanski
Max Planck Institute for Molecular Plant Physiology, Am Mühlenberg 1, Golm, 14476 Germany
Search for more papers by this authorMasami Y. Hirai
RIKEN Plant Science Center, Yokohama-shi, 17-2-2 Tsurumi-ku, Suehiro-cho, 230-0045 Japan
Search for more papers by this authorJoachim Selbig
Max Planck Institute for Molecular Plant Physiology, Am Mühlenberg 1, Golm, 14476 Germany
Search for more papers by this authorLothar Willmitzer
Max Planck Institute for Molecular Plant Physiology, Am Mühlenberg 1, Golm, 14476 Germany
Search for more papers by this authorZoran Nikoloski
Max Planck Institute for Molecular Plant Physiology, Am Mühlenberg 1, Golm, 14476 Germany
Search for more papers by this authorKazuki Saito
RIKEN Plant Science Center, Yokohama-shi, 17-2-2 Tsurumi-ku, Suehiro-cho, 230-0045 Japan
Search for more papers by this authorHenning Redestig,
Jedrzej Szymanski,
Masami Y. Hirai,
Joachim Selbig,
Lothar Willmitzer,
Zoran Nikoloski,
Kazuki Saito,
Henning Redestig
RIKEN Plant Science Center, Yokohama-shi, 17-2-2 Tsurumi-ku, Suehiro-cho, 230-0045 Japan
Search for more papers by this authorJedrzej Szymanski
Max Planck Institute for Molecular Plant Physiology, Am Mühlenberg 1, Golm, 14476 Germany
Search for more papers by this authorMasami Y. Hirai
RIKEN Plant Science Center, Yokohama-shi, 17-2-2 Tsurumi-ku, Suehiro-cho, 230-0045 Japan
Search for more papers by this authorJoachim Selbig
Max Planck Institute for Molecular Plant Physiology, Am Mühlenberg 1, Golm, 14476 Germany
Search for more papers by this authorLothar Willmitzer
Max Planck Institute for Molecular Plant Physiology, Am Mühlenberg 1, Golm, 14476 Germany
Search for more papers by this authorZoran Nikoloski
Max Planck Institute for Molecular Plant Physiology, Am Mühlenberg 1, Golm, 14476 Germany
Search for more papers by this authorKazuki Saito
RIKEN Plant Science Center, Yokohama-shi, 17-2-2 Tsurumi-ku, Suehiro-cho, 230-0045 Japan
Search for more papers by this authorThis article was originally published in 2011 in Biology of Plant Metabolomics, Volume 43 (ISBN 9781405199544) of the Annual Plant Reviews book series, this volume edited by Robert D. Hall. The article was republished in Annual Plant Reviews online in April 2018.
Abstract
As analytical techniques and data pre-processing methods continue to improve, the bottleneck of metabolomics is shifting towards later stages of data analysis and biological interpretation. High-coverage metabolomics is only possible when combining data from multiple platforms necessitating efficient methods for data integration. Metabolomic data sets with high coverage provide a unique opportunity to estimate and study metabolic networks. Once established, these networks can provide a backbone for systems biology approaches where the aim is to construct fundamental models of metabolic regulation. In this chapter, we provide an overview of status of these topics and describe current methods and tools, their drawbacks and advantages for integrative plant metabolomics.
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