In order to understand flow regularity and select oxygen lancer operating parameters of the two side-blown oxygen-enriched copper smelting process, commercial software Ansys/Fluent13.0 was used to simulate the flow characteristics of multiphase flow in the bath under different nozzle arrangement. The results showed that when the nozzle arrangement was compact, the stirring effect of gas was enhanced and the local velocity and turbulent kinetic energy of the fluid increased while the fluctuation of copper matte layer was intensified. Meanwhile, local gas holdup also increased, which caused uneven distribution of gas near the oxygen lacer. However, when the nozzle arrangement was sparse, the stirring strength decreased in the smelting zone. The flow fields obtained by PIV technology agreed well with the CFD results, which indicated that the numerical simulation results were reliable. The results above provided theoretical foundation for the further study on the two side-blown copper smelting process.