Chapter 41
Bartonella Infections
Sonia Kamath,
Minnelly Luu,
Sonia Kamath
Department of Dermatology, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA
Search for more papers by this authorMinnelly Luu
Department of Dermatology, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA
Division of Pediatric Dermatology, Children's Hospital Los Angeles, Los Angeles, CA, USA
Search for more papers by this authorSonia Kamath,
Minnelly Luu,
Sonia Kamath
Department of Dermatology, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA
Search for more papers by this authorMinnelly Luu
Department of Dermatology, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA
Division of Pediatric Dermatology, Children's Hospital Los Angeles, Los Angeles, CA, USA
Search for more papers by this authorBook Editor(s):Peter Hoeger,
Veronica Kinsler,
Albert Yan,
John Harper,
Arnold Oranje,
Christine Bodemer,
Margarita Larralde,
David Luk, Vibhu Mendiratta,
Diana Purvis,
Peter Hoeger
Search for more papers by this authorVeronica Kinsler
Search for more papers by this authorAlbert Yan
Search for more papers by this authorJohn Harper
Search for more papers by this authorArnold Oranje
Search for more papers by this authorChristine Bodemer
Search for more papers by this authorMargarita Larralde
Search for more papers by this authorVibhu Mendiratta
Search for more papers by this authorDiana Purvis
Search for more papers by this authorFirst published: 20 November 2019
Summary
The spectrum of Bartonella infections includes cat scratch disease (CSD), bacillary angiomatosis, trench fever and bartonellosis (or Carrion disease). In immunocompetent individuals, B. henselae infection results in CSD, characterized by self-limited regional lymphadenopathy after a cat scratch or bite distal to the affected node. Histologically, CSD manifests as a granulomatous process. By contrast, B. henselae or B. quintana infection in immunocompromised hosts results in bacillary angiomatosis, comprised of vascular papules and nodules with lobular vascular proliferations of plump endothelial cells on histology. Lesions generally respond well to therapy with erythromycin. Lastly, bartonellosis is caused by B. bacilliformis and transmitted from person to person by sandflies in certain regions of Peru, Colombia and Ecuador. Bartonellosis is characterized by acute and chronic presentations. The acute Oroya fever phase may lead to severe, life-threatening anaemia and requires treatment with chloramphenicol. The chronic verruga peruana phase is associated with less morbidity and responds well to rifampicin (rifampin).
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