Chapter 161
Nail Disorders
Antonella Tosti,
Bianca Maria Piraccini,
Antonella Tosti
Department of Dermatology and Cutaneous Surgery, Miller Medical School University of Miami, Miami, FL, USA
Search for more papers by this authorBianca Maria Piraccini
Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
Search for more papers by this authorAntonella Tosti,
Bianca Maria Piraccini,
Antonella Tosti
Department of Dermatology and Cutaneous Surgery, Miller Medical School University of Miami, Miami, FL, USA
Search for more papers by this authorBianca Maria Piraccini
Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
Search for more papers by this authorBook Editor(s):Peter Hoeger,
Veronica Kinsler,
Albert Yan,
John Harper,
Arnold Oranje,
Christine Bodemer,
Margarita Larralde,
David Luk, Vibhu Mendiratta,
Diana Purvis,
Peter Hoeger
Search for more papers by this authorVeronica Kinsler
Search for more papers by this authorAlbert Yan
Search for more papers by this authorJohn Harper
Search for more papers by this authorArnold Oranje
Search for more papers by this authorChristine Bodemer
Search for more papers by this authorMargarita Larralde
Search for more papers by this authorVibhu Mendiratta
Search for more papers by this authorDiana Purvis
Search for more papers by this authorSummary
Although rare, nail diseases in children are a source of anxiety for patients and should be recognized and treated, if possible. They may be congenital and hereditary or may be acquired. In the first two cases, nail signs are present at birth or develop during neonatal life and may occasionally be a sign of a syndrome or a systemic disorder. Acquired nail dystrophies are typical of the age of 5–10 years and are commonly due to psoriasis or infective conditions. Nail tumours are rare.
References
- Piraccini BM, Starace M. Nail disorders in infants and children. Curr Opin Pediatr 2014; 26: 440–5.
- Zaias N. The Nail in Health and Disease, 2nd edn. Norwalk, CT: Appleton and Lange, 1990.
- Crespel E, Plantin P, Schoenlaub P et al. Hyperpigmentation of the distal phalanx in healthy Caucasian neonates. Eur J Dermatol 2001; 11: 120–21.
- Iorizzo M, Oranje AP, Tosti A. Periungual hyperpigmentation in newborns. Pediatr Dermatol 2008; 25: 25–7.
-
Hamilton JB, Terada H, Mestler GE. Studies of growth throughout the lifespan in Japanese: growth and size of nails and their relationship to age, sex, heredity and other factors. J Gerontol 1995; 10: 401–15.
10.1093/geronj/10.4.401 Google Scholar
- Sibinga MS. Observations on growth of fingernails in health and disease. Pediatrics 1959; 24: 225–33.
- Wagner G, Sachse MM. Congenital malalignment of the big toe nail. J Dtsch Dermatol Ges 2012; 10: 326–30.
- Fierro-Arias L, Morales-Martínez A, Zazueta-López RM et al. Congenital malalignment of the great toenail. Skinmed 2015; 13: 433–7.
- Jellinek NJ. Flaps in nail surgery. Dermatol Ther 2012; 25: 535–44.
- Piraccini BM, Parente GL, Varotti E et al. Congenital hypertrophy of the lateral nail folds of the hallux: clinical features and follow-up of seven cases. Pediatr Dermatol 2000; 17: 348–51.
- Tsunoda M, Tsunoda K. Patient-controlled taping for the treatment of ingrown toenails. Ann Fam Med 2014; 12: 553–5.
- Matsui T, Kidou M, Ono T. Infantile multiple ingrowing nails of the fingers induced by the grasp reflex: a new entity. Dermatology 2002; 205: 25–7.
- Parry EJ. Chevron nail/herringbone nail. J Am Acad Dermatol 1999; 40: 497–8.
- Durdu M, Ruocco V. Clinical and cytologic features of antibiotic-resistant acute paronychia. J Am Acad Dermatol 2014; 70: 120–6.
- Haneke E. Nail surgery. Clin Dermatol 2013; 31: 516–25.
- Piraccini BM, Bruni F, Starace M. Dermoscopy of nonskin cancer nail disorders. Dermatol Ther 2012; 25: 594–602.
- Tosti A, Piraccini BM. Warts of the nail unit: surgical and non surgical approaches. Dermatol Surg 2001; 27: 235–9.
- Choi Y, Kim do H, Jin SY, et al. Topical immunotherapy with diphenylcyclopropenone is effective and preferred in the treatment of periungual warts. Ann Dermatol 2013; 25: 434–9.
- Smith L, Tracy DK, Giaroli G. What future role might N-acetyl-cysteine have in the treatment of obsessive compulsive and grooming disorders? A systematic review. J Clin Psychopharmacol 2016; 36: 57–62.
- Hjorth N, Thomsen K. Parakeratosis pustulosa. Br J Dermatol 1967; 79: 527–32.
- Tosti A, Peluso AM, Zucchelli V. Clinical features and long term follow-up of 2 cases of parakeratosis pustulosa. Pediatr Dermatol 1998; 15: 259–63.
- Piraccini BM, Triantafyllopoulou I, Prevezas C et al. Nail psoriasis in children: common or uncommon results from a 10-year double-center study. Skin App Dis 2015; 1: 43–8.
- Al-Mutairi N, Manchanda Y, Nour-Eldin O. Nail changes in childhood psoriasis: a study from Kuwait. Pediatr Dermatol 2007; 24: 7–10.
- Gordon KA, Vega JM, Tosti A. Trachyonychia: a comprehensive review. Indian J Dermatol Venereol Leprol 2011; 77: 640–5.
- Tosti A, Piraccini BM. Trachyonychia or twenty-nail dystrophy. Curr Opin Dermatol 1996; 3: 83–6.
- Tosti A, Piraccini BM, Cambiaghi S et al. Nail lichen planus in children. Clinical features, response to treatment and long term follow up. Arch Dermatol 2001; 137: 1027–32.
- Tosti A, Piraccini BM, Fanti PA et al. Idiopathic atrophy of the nails: clinical and pathological study of 2 cases. Dermatology 1995; 190: 116–18.
- Tosti A, Peluso AM, Fanti PA et al. Nail lichen planus: clinical study of 24 patients. J Am Acad Dermatol 1993; 28: 724–30.
- Tosti A, Peluso AM, Misciali C et al. Nail lichen striatus: clinical features and long-term follow-up of five cases. J Am Acad Dermatol 1997; 36: 908–13.
- Feely MA, Silverberg NB. Two cases of lichen striatus with prolonged active phase. Pediatr Dermatol 2014; 31: e67–8.
- Youssef SM, Teng JM. Effective topical combination therapy for treatment of lichen striatus in children: a case series and review. J Drugs Dermatol 2012; 11: 872–5.
- DaCambra MP, Gupta SK, Ferri-de-Barros F. Subungual exostosis of the toes: a systemic review. Clin Orthop Relat Res 2014; 472: 1251–9.
- Tosti A, Baran R, Piraccini BM et al. Nail matrix nevi: a clinical and pathological study of 22 patients. J Am Acad Dermatol 1996; 34: 765–71.
- Goettmann-Bonvallot S, Andre J, Belaich S. Longitudinal melanonychia in children: a clinical and histopathologic study of 4 cases. J Am Acad Dermatol 1999; 41: 17–22.
- Tosti A, Baran R, Morelli R et al. Progressive fading of longitudinal melanonychia due to a nail matrix melanocytic nevus in a child. Arch Dermatol 1994; 130: 1076–7.
- Ronger S, Touzet S, Ligeron C et al. Dermoscopic examination of nail pigmentation. Arch Dermatol 2002; 138: 1327–33.
- Tosti A, Piraccini BM, de Farias DC. Dealing with melanonychia. Semin Cutan Med Surg 2009; 28: 49–54.
- Iorizzo M, Tosti A, di Chiacchio N et al. Nail melanoma in children: differential diagnosis and management. Dermatol Surg 2008; 34: 974–8.
- Baran R. Syndrome d'Iso et Kikuchi. Ann Dermatol Vénéréol 1980; 107: 431.
- Valerio E, Favot F, Mattei I et al. Congenital isolated Iso–Kikuchi syndrome in a newborn. Clin Case Rep 2015; 3: 866–9.
- McIntosh I, Dreyer SD, Clough MV et al. Mutation analysis of LMX1B gene in nail patella syndrome patients. Am J Hum Genet 1998; 63: 1651–8.
- Bongers EM, Gubler MC, Knoers NV. Nail–patella syndrome: overview on clinical and molecular findings. Pediatr Nephrol 2002; 17: 703–12.
- Neri I, Piccolo V, Balestri R et al. Median nail damage in nail–patella syndrome associated with triangular lunulae. Br J Dermatol 2015; 173: 1559–61.
- Little KJ, Cornwall R. Congenital anomalies of the hand – principles of management. Orthop Clin North Am 2016; 47: 153–68.
- Tosti A, Paoluzzi P, Baran R. Doubled nail of the thumb: a rare form of polydactyly. Dermatology 1992; 184: 216–18.
- Tosti A, de Farias DC, Murrell DF. Nail involvement in epidermolysis bullosa. Dermatol Clin 2010; 28: 153–7.
- Dharma B, Moss C, McGrath JA et al. Dominant dystrophic epidermolysis bullosa presenting as familial nail dystrophy. Clin Exp Dermatol 2001; 26: 93–6.
- Shah S, Boen M, Kenner-Bell B et al. Pachyonychia congenita in pediatric patients: natural history, features, and impact. JAMA Dermatol 2014; 150: 146–53.
- Eliason MJ, Leachman SA, Feng BJ et al. A review of the clinical phenotype of 254 patients with genetically confirmed pachyonychia congenita. J Am Acad Dermatol 2012; 67: 680–6.
- Dessart P, Deries X, Guérin-Moreau M et al. Yellow nail syndrome: two pediatric case reports. Ann Dermatol Venereol 2014; 141: 611–19.
