Chapter 72
Fatigue
Angela Ju,
Mark Unruh,
Sarbjit Vanita Jassal,
Allison Tong,
Angela Ju
Sydney School of Public Health, University of Sydney, NSW, Australia
Centre for Kidney Research, Children's Hospital at Westmead, Westmead, NSW, Australia
Search for more papers by this authorMark Unruh
Division of Nephrology, University of New Mexico School of Medicine, Albuquerque, NM, USA
New Mexico VA Health Care System, Albuquerque, NM, USA
Search for more papers by this authorSarbjit Vanita Jassal
Division of Nephrology, Department of Medicine, University of Toronto, Toronto, ON, Canada
Search for more papers by this authorAllison Tong
Sydney School of Public Health, University of Sydney, NSW, Australia
Centre for Kidney Research, Children's Hospital at Westmead, Westmead, NSW, Australia
Search for more papers by this authorAngela Ju,
Mark Unruh,
Sarbjit Vanita Jassal,
Allison Tong,
Angela Ju
Sydney School of Public Health, University of Sydney, NSW, Australia
Centre for Kidney Research, Children's Hospital at Westmead, Westmead, NSW, Australia
Search for more papers by this authorMark Unruh
Division of Nephrology, University of New Mexico School of Medicine, Albuquerque, NM, USA
New Mexico VA Health Care System, Albuquerque, NM, USA
Search for more papers by this authorSarbjit Vanita Jassal
Division of Nephrology, Department of Medicine, University of Toronto, Toronto, ON, Canada
Search for more papers by this authorAllison Tong
Sydney School of Public Health, University of Sydney, NSW, Australia
Centre for Kidney Research, Children's Hospital at Westmead, Westmead, NSW, Australia
Search for more papers by this authorBook Editor(s):Jonathan C. Craig MBChB, DipCH, MMed(Clin Epi), PhD, FAHMS,
Donald A. Molony MD,
Giovanni F.M. Strippoli MD, PhD, MPH, MM (Epi),
Jonathan C. Craig MBChB, DipCH, MMed(Clin Epi), PhD, FAHMS
Matthew Flinders Distinguished Professor Vice President and Executive Dean
College of Medicine and Public Health, Flinders University, Adelaide, Australia
Search for more papers by this authorDonald A. Molony MD
Professor of Medicine Distinguished Teaching Professor of the University of Texas System
Division of Renal Diseases and Hypertension AND Center for Clinical Research and Evidence-based Medicine, McGovern Medical School University of Texas, Houston, TX, USA
Search for more papers by this authorGiovanni F.M. Strippoli MD, PhD, MPH, MM (Epi)
Professor of Nephrology Adjunct Professor of Epidemiology
Department of Emergency and Organ Transplantation – University of Bari, Bari, Italy
School of Public Health, University of Sydney, Sydney, NSW, Australia
Search for more papers by this authorFirst published: 18 November 2022
Summary
In hemodialysis, fatigue has been identified by patients, caregivers, and health professionals as the most important patient-reported outcome to report in trials. Psychosocial factors such as mood disorders and social support are also associated with fatigue. Peripheral or physical fatigue refers to the inability to exert or sustain muscle force. Fatigue, as experienced by patients on hemodialysis, can be largely divided into two types: postdialysis fatigue and general fatigue. There is a wide range of measures used to assess fatigue in patients across the spectrum of chronic kidney disease. Physiological contributors have long been examined in patients on hemodialysis but a range of variables have been linked to fatigue only in the last couple of decades. A number of studies in the cancer population have reported improved fatigue in patients prescribed low-dose short acting methylphendidate. Reflexology and stimulation of acupoints have been studied as methods of fatigue management in patients on hemodialysis.
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