Chapter 32
Clinical and Pathological Features, and Diagnosis
Sieberhagen Cyril,
Matthew E. Cramp,
Sieberhagen Cyril
South West Liver Unit, Derriford Hospital and Plymouth University Peninsula School of Medicine and Dentistry, Plymouth, UK
Search for more papers by this authorMatthew E. Cramp
South West Liver Unit, Derriford Hospital and Plymouth University Peninsula School of Medicine and Dentistry, Plymouth, UK
Search for more papers by this authorSieberhagen Cyril,
Matthew E. Cramp,
Sieberhagen Cyril
South West Liver Unit, Derriford Hospital and Plymouth University Peninsula School of Medicine and Dentistry, Plymouth, UK
Search for more papers by this authorMatthew E. Cramp
South West Liver Unit, Derriford Hospital and Plymouth University Peninsula School of Medicine and Dentistry, Plymouth, UK
Search for more papers by this authorBook Editor(s):Howard C. Thomas BSc, PhD, FRCP, FRCPath, FMedSci,
Anna S.F. Lok MD,
Stephen A. Locarnini MBBS, BSc(Hons), PhD, FRCPath,
Arie J. Zuckerman MD, DSc, FRCP, FRCPath, FMedSci,
Howard C. Thomas BSc, PhD, FRCP, FRCPath, FMedSci
Emeritus Professor of Hepatology, Department of Medicine, Imperial College London, London, UK
Search for more papers by this authorAnna S.F. Lok MD
Alice Lohrman Andrews Research Professor in Hepatology, Director of Clinical Hepatology, Professor of Internal Medicine, Associate Chair for Clinical Research, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA
Search for more papers by this authorStephen A. Locarnini MBBS, BSc(Hons), PhD, FRCPath
Head, Research & Molecular Development, Victorian Infectious Diseases Reference Laboratory, Melbourne, VIC, Australia
Search for more papers by this authorArie J. Zuckerman MD, DSc, FRCP, FRCPath, FMedSci
Emeritus Professor of Medical Microbiology, Formerly Principal and Dean, Royal Free Hospital School of Medicine
Search for more papers by this authorSummary
Hepatitis E virus (HEV) is a common infection worldwide resulting in significant morbidity. It typically results in a self-limiting illness characterized by the development of acute hepatitis, and the treatment is usually conservative. Overall, mortality due to HEV infection is low and arises from occasional cases of acute liver failure or cases with preexisting liver disease. In pregnant women in developing countries, however, it is a serious infection with a high mortality. Recent evidence has suggested that chronicity can occur in the immunosuppressed and that this may lead to progressive liver injury and possible cirrhosis. Extrahepatic manifestations have also been described. There is evidence that treatment may be of benefit in the immunosuppressed and those with extrahepatic manifestations, although further research is required. HEV is increasingly being recognized in developed countries, and it should be considered as a cause in anyone presenting with hepatitis.
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