Esophageal Squamous Cell Carcinomas and Other Neoplasms
Adam J. Bass
Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
Search for more papers by this authorAnil K. Rustgi
University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Search for more papers by this authorAdam J. Bass
Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
Search for more papers by this authorAnil K. Rustgi
University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Search for more papers by this authorDaniel K. Podolsky MD
President, University of Texas Southwestern Medical Center, Professor of Internal Medicine, Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX, USA
Search for more papers by this authorMichael Camilleri MD
Executive Dean for Development, Atherton and Winifred W. Bean Professor, Professor of Medicine, Physiology and Pharmacology, Distinguished Investigator, Mayo Clinic, Rochester, MN, USA
Search for more papers by this authorJ. Gregory Fitz MD FAASLD
Executive Vice President for Academic Aff airs and Provost, University of Texas Southwestern Medical Center, Dean, Professor of Internal Medicine, Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX, USA
Search for more papers by this authorAnthony N. Kalloo MD
Professor of Medicine, Johns Hopkins University School of Medicine, Director, Division of Gastroenterology & Hepatology, Johns Hopkins Hospital, Baltimore, MD, USA
Search for more papers by this authorFergus Shanahan MD
Professor and Chair, Department of Medicine, Director, Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland, Cork, Ireland
Search for more papers by this authorTimothy C. Wang MD
Chief, Division of Digestive and Liver Diseases, Silberberg Professor of Medicine, Department of Medicine and Irving Cancer Research Center, Columbia University Medical Center, New York, NY, USA
Search for more papers by this authorSummary
Esophageal cancers are common in the United States and worldwide. The two most common subtypes of esophageal cancer are esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma. A combination of environmental, dietary and lifestyle factors conspire with genetic, epigenetic and genomic alterations to transform the normal esophageal epithelium to dysplasia and eventually ESCC. Staging is critical in ESCC, which influences the types of and timing of therapeutic modalities. Novel diagnostics and therapeutics hold promises in improving ESCC outcomes.
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