Chapter 53

Esophageal Squamous Cell Carcinomas and Other Neoplasms

Adam J. Bass

Adam J. Bass

Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA

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Anil K. Rustgi

Anil K. Rustgi

University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA

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First published: 27 November 2015

Summary

Esophageal cancers are common in the United States and worldwide. The two most common subtypes of esophageal cancer are esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma. A combination of environmental, dietary and lifestyle factors conspire with genetic, epigenetic and genomic alterations to transform the normal esophageal epithelium to dysplasia and eventually ESCC. Staging is critical in ESCC, which influences the types of and timing of therapeutic modalities. Novel diagnostics and therapeutics hold promises in improving ESCC outcomes.

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