Chapter 23
Fish-elastin Hydrolysate: Development and Impact on the Skin and Blood Vessels
Eri Shiratsuchi, Misako Nakaba, Yasutaka Shigemura,
Michio Yamada, Kenji Sato,
Yasutaka Shigemura
Department of Nutrition, Faculty of Domestic Science, Tokyo Kasei University, Tokyo, Japan
Search for more papers by this authorKenji Sato
Division of Applied Life Sciences, Graduate School of Life and Environment Sciences, Kyoto Prefectural University, Kyoto, Japan
Search for more papers by this authorEri Shiratsuchi, Misako Nakaba, Yasutaka Shigemura,
Michio Yamada, Kenji Sato,
Yasutaka Shigemura
Department of Nutrition, Faculty of Domestic Science, Tokyo Kasei University, Tokyo, Japan
Search for more papers by this authorKenji Sato
Division of Applied Life Sciences, Graduate School of Life and Environment Sciences, Kyoto Prefectural University, Kyoto, Japan
Search for more papers by this authorBook Editor(s):Se-Kwon Kim,
Se-Kwon Kim
Marine Bioprocess Research Center, Pukyong National University, Busan, Republic of Korea
Department of Chemistry, Pukyoung National University, Nam-Gu, Busan, Republic of Korea
Search for more papers by this authorSummary
This chapter introduces the development of enzymatic hydrolysate of fish elastin and also discusses its underlying mechanism. The skipjack bulbus arteriosus has been used for the production of elastin hydrolysate, due to the availability and abundance of resource. The chapter explains the impact of ingestion of the elastin hydrolysate in the skin and blood vessels. To explore the mechanism underlying the beneficial effects of skipjack-elastin hydrolysate, a food-derived elastin peptide in the human blood was screened. Consequently, Pro-Gly was identified. Pro-Gly enhances synthesis of elastin by human dermal fibroblast and the growth of human umbilical-vein endothelial cells. The results of the human trials and the occurrence of food-derived elastin peptide with biological activities in human blood indicate that fish-elastin hydrolysate is a promising food ingredient for improving skin and blood-vessel conditions.
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