Chapter 1

History of Research on the AHR

Thomas A. Gasiewicz

Thomas A. Gasiewicz

Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA

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Ellen C. Henry

Ellen C. Henry

Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA

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First published: 10 November 2011
Citations: 4

Summary

This chapter contains sections titled:

  • Introduction

  • A Hypothesis is Conceived, and Genetically Defined Growth and Expansion of the Hypothesis Leads to the Identification of the Ah Locus

  • A Focus on Public Health Leads to the Identification of The Ah Receptor

  • The 1980s: Growth and Maturation of the Paradigm

  • Details, Details

  • Let us not Forget the Toxicology

  • Recognizing the Importance of Regulating AHR Presence and Activity

  • Ahre-Dependent Versus Ahreindependent Pathways

  • The Physiological Role is Still Elusive

  • Summary and Future of AHR Research

  • References

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