Radiofrequency Energy, Biological Effects of
Kenneth R. Foster
University of Pennsylvania, Department of Bioengineering, Philadelphia, Pennsylvania
Search for more papers by this authorKenneth R. Foster
University of Pennsylvania, Department of Bioengineering, Philadelphia, Pennsylvania
Search for more papers by this authorAbstract
This chapter reviews the interaction of radiofrequency (RF) energy with tissue, including mechanisms of interaction, principles of exposure assessment, and known or reported biological effects. Major therapeutic effects and potential hazards of RF energy are described, together with the basis for major exposure limits. Major areas of controversy about biological effects of radiofrequency energy are reviewed. A supplemental reading guide includes links to expert panel reports on health effects of RF energy.
Bibliography
- 1K. R. Foster, Biological effects of radiofrequency energy as related to health and safety. Encyclopedia of RF, Microwave Engineering. New York: Wiley, 2004.
- 2K. R. Foster and H. P. Schwan, Dielectric properties of tissues—a review. In: C. Polk and E. Postow, eds., Handbook of Biological Effects of Electromagnetic Radiation, 2nd ed. Boca Raton, FL: CRC Press, 1995.
- 3S. Gabriel, R. W. Lau, and C. Gabriel, The dielectric properties of biological tissues. 2. Measurements in the frequency range 10 Hz to 20 GHz. Phys. Med. Biol. 1996; 41: 2251–2269.
- 4T. Schmid, O. Egger, and N. Kuster, Automated E-field scanning system for dosimetric assessments. IEEE Trans. Microwave Theory Tech. 1996; 44: 105–113.
- 5C. H. Durney, H. Massoudi, M. F. lskander, Radiofrequency Radiation Dosimetry Handbook, 4th ed. San Antonio, TX: Brooks Air Force Base. Report USAFSAM-TR-85-73. Available: http://www.brooks.af.mil/AL/OE/OER/handbook/cover.htm.
- 6H. P. Schwan and K. R. Foster, RF-field interactions with biological systems: electrical properties and biophysical mechanisms. Proc. IEEE 1980; 68: 104–113.
- 7K. R. Foster and E. D. Finch, Microwave hearing: evidence for thermoacoustic auditory stimulation by pulsed microwaves. Science 1974; 185: 256–258.
- 8F. S. Barnes, Cell membrane temperature rate sensitivity predicted from the Nernst equation. Bioelectromagnetics 1984; 5: 113–115.
- 9H. Wachtel, D. Brown, and H. Bassen, Critical durations of pulse microwave exposures that evoke body movements. Bioelectromagnetics Society, 12th Annual Meeting, San Antonio, TX, June 10–14, 1990, p. 55.
- 10R. C. Lee, D. Zhang, and J. Hannig, Biophysical injury mechanisms in electrical shock trauma. Annu. Rev. Biomed. Eng. 2000; 2: 477–509.
- 11R. K. Adair, Biophysical limits on athermal effects of RF and microwave radiation. Bioelectromagnetics 2003; 24: 39–48.
- 12A. G. Pakhomov and M. R. Murphy, Low-intensity millimeter waves as a novel therapeutic modality. IEEE Trans. Plasma Sci. 2000; 28: 34–40.
- 13S. M. Michaelson and J. C. Lin, Biological Effects and Health Implications of Radiofrequency Radiation. New York: Plenum Press, 1987.
10.1007/978-1-4757-4614-3 Google Scholar
- 14International Commission on Non-Ionizing Radiation Protection, ICNIRP guidelines: guidelines for limiting exposure to time-varying electric, magnetic, and electromagnetic fields (up to 300 GHz). Health Phys. 1998; 74:494–522.
- 15I. Chatterjee, D. Wu, and O. P. Gandhi, Human body impedance and threshold currents for perception and pain for contact hazard analysis in the VLF-MF band. IEEE Trans. Biomed. Eng. 1986; 33: 486–494.
- 16D. W. Blick, E. R. Adair, W. D. Hurt, C. J. Sherry, T. J. Walters, and J. H. Merritt, Thresholds of microwave-evoked warmth sensations in human skin. Bioelectromagnetics 1997; 18: 403–409.
10.1002/(SICI)1521-186X(1997)18:6<403::AID-BEM1>3.0.CO;2-6 CAS PubMed Web of Science® Google Scholar
- 17P. J. Riu, K. R. Foster, D. W. Blick, and E. R. Adair, A thermal model for human thresholds of microwave-evoked warmth sensations. Bioelectromagnetics 1997; 18: 578–583.
10.1002/(SICI)1521-186X(1997)18:8<578::AID-BEM6>3.0.CO;2-# CAS PubMed Web of Science® Google Scholar
- 18T. J. Walters, D. W. Blick. L. R. Johnson, E. R Adair, and K. R. Foster, Heating and pain sensation produced in human skin by millimeter waves: comparison to a simple thermal model. Health Phys. 2000; 78: 259–267.
- 19M. W. Dewhirst, B. L. Viglianti, M. Lora-Michiels, M. Hanson, and P. J. Hoopes, Basic principles of thermal dosimetry and thermal thresholds for tissue damage from hyperthermia. Int. J. Hyperthermia 2003; 19: 267–294.
- 20R. C. Alexander, J. A. Surrell, and S. D. Cohle, Microwave oven burns to children: an unusual manifestation of child abuse. Pediatrics 1987; 79: 255–260.
- 21S. F. Cleary, Microwave cataractogenesis. Proc. IEEE 1980; 68: 49–55.
- 22P. S. Nawrot, D. I. McRee, and R. E. Staples, Effects of 2.45 GHz microwave radiation on embryofetal development in mice. Teratology 1981; 24: 303–314.
- 23R. P. Jensh, Behavioral teratologic studies using microwave radiation: is there an increased risk from exposure to cellular phones and microwave ovens? Reprod. Toxicol. 1997; 11: 601–611.
- 24Y. H. Liu, X. M. Li, R. P. Zou, and F. B. Li, Biopsies of human testes receiving multiple microwave irradiation—an histological and ultramicroscopical study. J. Bioelectricity 1991; 10: 213–230.
- 25J. A. D’Andrea, Microwave radiation absorption: behavioral effects. Health Phys. 1991; 61: 29–40.
- 26J. Osepchuk and R. C. Petersen, Safety standards for exposure to RF electromagnetic fields. IEEE Microwave Mag. 2001; June:57–69.
- 27J. M. Elwood, Epidemiological studies of radio frequency exposures and human cancer. Bioelectromagnetics 2003; 24(Suppl. 6): S63–S73.
- 28IEEE Std C95.1-1999, IEEE Standard for Safety Levels With Respect to Human Exposure to Radiofrequency Electromagnetic Fields, 3 kHz to 300 GHz, 1999 (available from the Institute of Electrical and Electronics Engineers, Inc., Service Center, 445 Hoes Lane, Piscataway, NJ 08854-1331).
- 29K. R. Foster and W.F. Pickard, Microwaves: the risks of risk research. Nature 1987; 330: 531–532.
- 30R. L. Davis and F. K. Mostofi, Cluster of testicular cancer in police officers exposed to hand-held radar. Am. J. Ind. Med. 1993; 24: 231–233.
- 31S. Szmigielski, Cancer morbidity in subjects occupationally exposed to high frequency (radiofrequency and microwave) electromagnetic radiation. Sci. Total Environ. 1996; 180: 9–17.
- 32R. Santini, P. Santini, J. M. Danze, P. Le Ruz, and M. Seigne, Investigation on the health of people living near mobile telephone relay stations: incidence according to distance and sex. Pathol. Biol. (Paris) 2002; 50: 369–373.
- 33N. J. Roberts and S. M. Michaelson, Epidemiological studies of human exposures to radiofrequency radiation. A critical review. Int. Arch. Occup. Environ. Health 1985; 56: 169–178.
- 34Royal Society of Canada. (1999). A Review of the Potential Health Risks of Radiofrequency Fields from Wireless Telecommunication Devices (online). Available: http://www.rsc.ca/english/RFreport.html.
- 35Independent Expert Group on Mobile Phones. (2000). Mobile Phones and Health, National Radiological Protection Board (UK) (online). Available: http://www.iegmp.org.uk/IEGMPtxt.htm.
- 36M. H. Repacholi, Radiofrequency electromagnetic-field exposure standards. IEEE Eng. Med. Biol. 1987; 6: 18–21.
Further Reading
- C. Polk and E. Postow, eds., Handbook of Biological Effects of Electromagnetic Fields, 2nd ed. Boca Raton, FL: CRC Press, 1996 (A collection of review chapters including biological effects of RF energy, dosimetry, and electrical properties of tissue).
- S. M. Michaelson and J. C. Lin, Biological Effects and Health Implications of Radiofrequency Radiation, New York: Plenum Press, 1987 (a now-dated review, but with extensive discussion of earlier literature).
10.1007/978-1-4757-4614-3 Google Scholar
- O. P. Gandhi, ed., Biological Effects and Medical Applications of Electromagnetic Energy. Englewood Cliffs, NJ: Prentice-Hall, 1990 (several excellent review articles on bioeffects, dosimetry, medical applications of RF energy).
- An entire issue of the journal Bioelectromagnetics appeared in 2003 (Volume 24, Supplement 6) with 12 reviews of biological effects of RF fields covering a wide variety of subject areas.
- J. D. Boice and J. K. McLaughlin, Epidemiological studies of cellular telephones and cancer risk—a review. Stockholm, Swedish Radiation Protection Authority, 2002. Available: http://www.ssi.se/ssi_rapporter/pdf/ssi_rapp_2002_16.pdf.
- C.-K. Chou, H. Bassen, J. Osepchuk, Q. Balzano, R. Petersen, M. Meltz, R. Cleveland, J. C. Lin, and L. Heynick, Radiofrequency electromagnetic exposure: tutorial review on experimental dosimetry. Bioelectromagnetics 1996; 17: 195–208 (excellent review of dosimetry).
10.1002/(SICI)1521-186X(1996)17:3<195::AID-BEM5>3.0.CO;2-Z CAS PubMed Web of Science® Google Scholar
- R. W. Habash, L. M. Brodsky, W. Leiss, D. Krewski, and M. Repacholi, Health risks of electromagnetic fields. Part II: evaluation and assessment of radio frequency radiation. Crit. Rev. Biomed. Eng. 2003; 31: 197–254 (recent comprehensive review).
- K. A. Hossmann and D. M. Hermann, Effects of electromagnetic radiation of mobile phones on the central nervous system. Bioelectromagnetics 2003; 24: 49–62 (review of possible neurologic effects of RF energy, with reference to mobile phones).
- E. Litvak, K. R. Foster, M. H. Repacholi, Health and safety implications of exposure to electromagnetic fields in the frequency range 300 Hz–10 MHz. Bioelectromagnetics 2002; 23: 68–82 (one of the few available reviews of biological effects of RF energy below 10 MHz).
- Health Council of the Netherlands, Mobile telephones; an evaluation of health effects. The Hague, the Netherlands: Health Council of the Netherlands, 2002. Available: http://www.gr.nl/pdf.php?ID=886.
- Independent Expert Group On Mobile Phones. (2000). Mobile Phones and Health, UK (online). Available: http://www.iegmp.org.uk/index.htm.
- National Radiation Protection Board (UK), Advisory Group on Non-ionising Radiation, Health effects from radiofrequency electromagnetic fields: report of an independent advisory group on non-ionising radiation. Available: http://www.nrpb.org/publications/documents_of_nrpb/abstracts/absd14-2.htm.
- New Zealand Ministry for the Environment. (2000). National Guidelines for Managing the Effects of Radiofrequency Transmitters (online). Available: http://www.mfe.govt.nz/publications/rma/radio-freq-guidelines-dec00.pdf.
- The Royal Society of Canada. (1999). A Review of the Potential Health Risks of Radiofrequency Fields from Wireless Telecommunication Devices (online). Available: http://www.rsc.ca/english/RFreport.html.
- Swedish Radiation Protection Authority (SSI). (2003). First Annual Report from SSI's Independent Expert Group on Electromagnetic Fields (online). Available: http://www.ssi.se/english/english_news.html.
- Zmirou. (2001). Report to the French Health General Directorate (online). Available: http://www.sante.gouv.fr/htm/dossiers/telephon_mobil/teleph_uk.htm.
Internet Sites
Bioelectromagnetics Society, the major professional society concerned with studies of possible health and safety issues related to RF energy http://bioelectromagnetics.org.
FAQ sheets related to electromagnetic fields and health by John Moulder at The Medical College of Wisconsin offers comprehensive and up-to-date reviews about mobile phones and health and other issues www.mcw.edu/gcrc/cop/cell-phone-health-faq/toc.html.
IEEE Committee on Man and Radiation (COMAR) prepares “technical information statements” on issues related to health and safety of electromagnetic fields. http://ewh.ieee.org/soc/embs/comar/.
International Commission on Non-Ionizing Radiation Protection (ICNIRP) is an international agency that establishes exposure guidelines for electromagnetic fields http://www.icnirp.de.
World Health Organization EMF Project offers an extensive array of information including “fact sheets: about health and safety issues related to RF energy, comparison of international exposure limits http://www.who.int/peh-emf/.