Chapter 28
Epidemiological Studies of Anticholinesterase Pesticide Poisoning in Greece
M. Stefanidou,
S. Athanaselis,
C. Spiliopoulou,
C. Maravelias,
M. Stefanidou
Department of Forensic Medicine and Toxicology, University of Athens, School of Medicine, 75, Mikras Asias str., Athens 115.27, Greece
Search for more papers by this authorS. Athanaselis
Department of Forensic Medicine and Toxicology, University of Athens, School of Medicine, 75, Mikras Asias str., Athens 115.27, Greece
Search for more papers by this authorC. Spiliopoulou
Department of Forensic Medicine and Toxicology, University of Athens, School of Medicine, 75, Mikras Asias str., Athens 115.27, Greece
Search for more papers by this authorC. Maravelias
Department of Forensic Medicine and Toxicology, University of Athens, School of Medicine, 75, Mikras Asias str., Athens 115.27, Greece
Search for more papers by this authorM. Stefanidou,
S. Athanaselis,
C. Spiliopoulou,
C. Maravelias,
M. Stefanidou
Department of Forensic Medicine and Toxicology, University of Athens, School of Medicine, 75, Mikras Asias str., Athens 115.27, Greece
Search for more papers by this authorS. Athanaselis
Department of Forensic Medicine and Toxicology, University of Athens, School of Medicine, 75, Mikras Asias str., Athens 115.27, Greece
Search for more papers by this authorC. Spiliopoulou
Department of Forensic Medicine and Toxicology, University of Athens, School of Medicine, 75, Mikras Asias str., Athens 115.27, Greece
Search for more papers by this authorC. Maravelias
Department of Forensic Medicine and Toxicology, University of Athens, School of Medicine, 75, Mikras Asias str., Athens 115.27, Greece
Search for more papers by this authorBook Editor(s):Tetsuo Satoh,
Ramesh C. Gupta,
Tetsuo Satoh
Department of Pharmacology and Toxicology, Japan
Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
HAB Research Institute, Ichikawa, Chiba, Japan
Search for more papers by this authorRamesh C. Gupta
Toxicology Department, Breathitt Veterinary Center, Murray State University, Hopkinsville, KY, USA
Search for more papers by this authorSummary
This chapter contains sections titled:
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Introduction
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Anticholinesterase Pesticides
-
Epidemiological Studies
-
Epidemiological Studies in Greece
-
Conclusions
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References
References
- Abdullat, E.M., Hadidi, M.S., Alhadidi, N., Suleiman, T., and Hadidi, K. (2006). Agricultural and horticultural pesticides fatal poisoning: The Jordanian experience 1999–2000. Journal of Clinical Forensic Medicine 13: 304–307.
- Alavanja, M.C.R., Blair, A., and Masters, M.N. (1990). Cancer mortality in the US flour industry. J. Natl Cancer Inst. 82: 840–848.
- Antoniou, V., Zantopoulos, N., and Tsoukali, H. (1997). Fatal animal poisonings in northern Greece: 1990–1995. Vet. Hum. Toxicol. 39(1): 35–36.
- Anwar, W.A. (1997). Biomarkers of human exposure to pesticides. Environ. Health Perspect. 105(Suppl. 4): 801–806.
- Atkins, E.L. (1992). Injury to honey bees by poisoning. In: J.M. Graham, (Ed.) The Hive and the Honey Bee. Dadant and Sons, Hamilton, Illinois, pp. 1153–1208.
- Bertsias, G.K., Katonis, P., Tzanakakis, G., and Tsatsakis, A.M. (2004). Review of clinical and toxicological features of acute pesticide poisonings in Crete (Greece) during the period 1991–2001. Med. Sci. Monit. 10(11): CR622–627.
- Beseler, C. et al. (2006). Depression and pesticide exposures in female spouses of licensed pesticide applicators in the Agricultural Health Study Cohort. J. Occup. Environ. Med. 48: 1005–1013.
- Blair, A., Grauman, D.J., Lubin, J.H., and Fraumeni, J.F. (1983). Lung cancer and other causes of death among licensed pesticide applicators. J. Natl Cancer Inst. 71: 31–37.
- Blair, A. et al. (1992). Clues to cancer etiology from studies of farmers. Scand J. Work Environ. Health 18: 209–215.
- Bonde, J.P. (2002). Occupational risk to male reproduction. G. Ital. Med. Lav. Ergon 24: 112–117.
- Boxer, P.A., Burnett, C., and Swanson, N. (1995). Suicide and occupation: A review of the literature. J. Occup. Environ. Med. 37: 442–452.
- Cantor, K.P. and Blair, A. (1984). Farming and mortality from multiple myeloma: A case-control study with the use of death certificates. J. Natl Cancer Inst. 27: 251–255.
- Carson, R. (2002). Silent Spring. 40th anniversary edn. New York: Houghton Mifflin.
- Chatzi, L., Alegakis, A., Tzanakis, N., Siafakas, N., Kogevinas, M., and Lionis, C. (2007). Association of allergic rhinitis with pesticide use among grape farmers in Crete, Greece. Occup. Environ. Med. 64(6): 417–421.
- Christakis-Hampsas, M.G. et al. (1998). Acute poisoning and sudden death in Crete: A five year review (1991–1996). Veterinary and Human Toxicology 40(4): 228–230.
- Claman, P. (2004). Men at risk: Occupation and male infertility. Fertil. Steril. 81: 19–26.
- Colborn, T., Dumanoski, D., and Myers, J.P. (1996). Our Stolen Future. Dutton, Toronto.
- Corrao, G. et al. (1989). Cancer risk in a cohort of licensed pesticide users. Scand. J. Work Environ. Health 15: 203–209.
- Damalas, C.A., Georgiou, E.B., and Theodorou, M.G. (2006). Pesticide use and safety practices among Greek tobacco farmers: A survey. Int. J. Environ. Health Res. 16(5): 339–348.
- Dinham, B. and Malik, S. (2003). Pesticides and human rights. Int. J. Occup. Environ. Health 9: 40–52.
- Dolapsakis, G., Vlachonikolis, I.G., Varveris, C., and Tsatsakis, A.M. (2001). Mammographic findings and occupational exposure to pesticides currently in use on Crete. Eur. J. Cancer 37(12): 1531–1536.
- Dunitz, M. and Malden, M.A. (2000). Cholinesterases and cholinesterase inhibitors, published in London, distributed in USA by Blackwell Science.
- Ecobichon, D.J. (2001). Toxic effects of pesticides. In: C.D. Klaassen, (Ed.), Casarett and Doull's Toxicology, The Basic Science of Poisons. Sixth Edition. The McGraw-Hill Companies Inc., USA, pp. 763–810.
- Eddleston, M., Singh, S., and Buckley, N. (2002). Acute organophosphorus poisoning. Clin. Evid. 8: 1436–1446. Review.
- Ehrich, M. (1998). Organophosphates. In: P. Wexler, (Ed.) Encyclopedia of Toxicology. Academic Press, California, pp. 467–471.
- Friedrich, M.J. (2005). Parkinson disease studies yield insights. JAMA 293: 409–410.
- Goumenou, M. and Machera, K. (2001). Determination of penconazole on personal protection equipment after field applications. Fresenius J. Anal. Chem. 370(7): 946–950.
- Hatzitolios, A.I. et al. (2001). Parasuicidal poisoning treated in a Greek medical ward: Epidemiology and clinical experience. Hum. Exp. Toxicol. 20(12): 611–617.
- Hill, R.H. et al. (1995). Pesticides residues in urine of adults living in the United States: Reference range concentrations. Environ. Res. 71(2): 99–108.
- Hoppin, J.A. et al. (2006). Pesticides and adult respiratory outcomes in the agricultural health study. Ann. NY Acad. Sci. 1076: 343–354.
- IARC. (1991). Occupational exposures in insecticide application, and some pesticides. In: IARC Monographs on the Evaluation of the Carcinogenic Risk Of Chemicals to Humans. Vol. 53. International Agency for Research on Cancer, Lyon.
- Innes, J.R.M. et al. (1969). Bioassay of pesticides and industrial chemicals for tumorigenicity in mice: A preliminary note. J. Natl Cancer Inst. 42: 1101–1114.
- Jeyararnam, J. (1990). Acute pesticides poisoning: A major global health problem. World Health Stat. Quart. 43: 139–144.
- Jones, W.A. (1998). Pesticides and Bees. Primary Industry and Fisheries, Agnote, 485, I17.
- Kafatos, A. et al. (1989). Effect of pesticides on health. Epidemiological study in the agricultural population of the island Crete, in Greece. Iatriki Bulletin, Vol. 56: 6, December.
- Kamel, F. and Hoppin, J.A. (2004). Association of pesticide exposure with neurologic dysfunction and disease. Environ. Health Perspect. 112: 950–958.
- Kiamouris, C. and Linou, A. (1989). Pesticides and malignant diseases of the immune system. Medicine 55: 554–559.
- Kourakis, A., Mouratidou, M., Barbouti, A., and Dimikiotou, M. (1996). Cytogenetic effects of occupational exposure in the peripheral blood lymphocytes of pesticides sprayers. Carcinogenesis 17(1): 99–101.
- Kourakis, A. et al. (1992). Frequencies of chromosomal aberrations in pesticide sprayers working in plastic greenhouses. Mutation Research 279: 45–148.
- Kovacic, P. (2003). Mechanism of organophosphates (nerve gases and pesticides) and antidotes: electron transfer and oxidative stress. Curr. Med. Chem. 10(24): 2705–2709. Review.
- Lee, W.J. et al. (2004). Cancer incidence among pesticide applicators exposed to chlorpyrifos in the Agricultural Health Study. J. Natl Cancer Inst. 96: 1781–1789.
- Lee, W.J. et al. (2007). Mortality among pesticide applicators exposed to chlorpyrifos in the Agricultural Health Study. Environ. Health Perspect. 115(4): 528–534.
- Linou, A., Kiamouris, C., and Tsoukas, A. (1988). The effect of agricultural profession in the development of leukemia and lymphoma in the Greek population. Iatriki Bulletin 54: 431–436.
- London, L., Flisher, A.J., Wesseling, C., Mergler, D., and Kromhoutb, H. (2005). Suicide and exposure to organophosphate insecticides: Cause or effect? Am. J. Ind. Med. 47: 308–321.
- Machera, K., Goumenou, M., Kapetanakis, E., KαI OEA55, K. (2000). Exposure of sprayers through the skin, the inhalation and all the organ systems after the application of the pesticide Malathion 50 EC in the tomato greenhouses. Second Panhellenic Congress of Forensic Medicine and Toxicology, Athens, Greece, 24–26 November.
- Machera, K., Kapetanakis, E., Charistou, A., Goumenaki, E., and Glass, R.C. (2002). Evaluation of potential dermal exposure of pesticide spray operators in greenhouses by use of visible tracers. J. Environ. Sci. Health B 37(2): 113–121.
- Machera, K., Goumenou, M., Kapetanakis, E., Kalamarakis, A., and Glass, C.R. (2003). Determination of potential dermal and inhalation operator exposure to malathion in greenhouses with the whole body dosimetry method. Ann. Occup. Hyg. 47(1): 61–70.
- MacMahon, B., Monson, R.R., Wang, H.H., and Zheng, T. (1988). A second follow-up of mortality in a cohort of pesticide applicators. (1989) J. Occup. Med. 30: 429–432.
- Makropoulos, V. and Machera, C. (2000). Research Program of the Benaki Phytopathological Institute, Athens, Greece, entitled “Development of a methodology for the assessment of the effects of pesticide combinations in human health.”
- Ntzaou, S., Zagelidou, H., and Tsoukali, H. (1996). Suicide of a man with carbofuran due to fear of having been infected with the HIV virus. Archives of the 11th Medical Congress of Northern Greece. Salonica, Greece, p. 592.
- Oomen, P.A. (2000). Honey bee poisoning incidents in the Netherlands over the last ten years. In: C. Pelissier and L.P. Belzunces, (Eds) Hazards of Pesticides to Bees. IOBC Wprs Bulletin. INRA, Dijon, France, 23, 3, 8.
- Pappas, F., Stefanidou, M., and Koutselinis, A. (1996). The lethal poisonings of domestic and company animals during the years 1986–1994. Bull. Hellenic Vet. Med. Soc. 47(3): 182–185.
- Perry, M.J. (2008). Effects of environmental and occupational pesticide exposure on human sperm: A systematic review. Environmental and Occupational Medicine and Epidemiology Program. Harvard School of Public Health, Boston, Human Reproduction Update 14(3): 233–242.
- Persson, B., Dahlander, A.M., Fredriksson, M., Brage, H.N., Ohlson, C.G., and Axelson, O. (1989). Malignant lymphomas and occupational exposures. Br. J. Ind. Med. 46: 516–520.
-
Pickett, W., King, W.D., Less, R.E., Bienefeld, M., Morrison, H.I., and Brison, R.J. (1998). Suicide mortality and pesticide use among Canadian farmers. Am. J. Ind. Med. 34: 364–372.
10.1002/(SICI)1097-0274(199810)34:4<364::AID-AJIM10>3.0.CO;2-0 CAS PubMed Web of Science® Google Scholar
- Piperakis, S.M. et al. (2003). Biomonitoring with the comet assay of Greek greenhouse workers exposed to pesticides. Environ. Mol. Mutagen. 41(2): 104–110.
- Pope, C. (1998). Neurotoxicology: Central and Peripheral. In: P. Wexler, (Ed.) Encyclopedia of Toxicology. Academic Press, California, pp. 494.
- Reimer, E., Radic, Z., and Simeon-Rudolf, V. (2007). Mechanisms of organophosphate toxicity and detoxication with emphasis on studies in Croatia. Arh. Hiq. Rada Toksikol. 1, 58(3): 329–338.
- Sanborn, M., Donald, C., Kerr, K., Vakil, C., Sanin, L.H., and Bassil, K. (2004). Pesticides Literature Review. The Ontario College of Family Physicians, Toronto. Ontario April 23, pp. 1–5.
- Sanne, B., Mykletun, A., Moen, B.E., Dahl, A.A., and Tell, G.S. (2004). Farmers are at risk for anxiety and depression: the Hordaland Health Study. Occup. Med. (Lond.) 54: 92–100.
- Scaps, P. (2004). Marine inverterbrate cholinesterases: Utilization as biomarkers of pesticide contamination. Current Topics in Toxicology 1: 145–151.
- Sharpe, R.M. and Irvine, D.S. (2004). How strong is the evidence of a link between environmental chemicals and adverse effects on human reproductive health. BMJ 328: 447–451.
-
Sperati, A., Rapiti, E., Settimi, L., Quercia, A., Terenzoni, B., and Forastiere, F. (1999). Mortality among male licensed pesticide users and their wives. Am. J. Ind. Med. 36: 142–146.
10.1002/(SICI)1097-0274(199907)36:1<142::AID-AJIM20>3.0.CO;2-E CAS PubMed Web of Science® Google Scholar
- Stefanidou, M. and Pappas, F. (1996). Assessment of the exposure of the Greek consumers to pesticide residues through the consumed food and the pharmaceutical products. Forensic Chronicles, B′, 2: 89–94.
- Stephanou, E. and Zourari, M. (1998). Exposure to pesticides in greenhouses. Determination of airborne residues and surface deposition. Toxicol. Environ. Chem. 25: 17–27.
- Stefanidou, M., Athanaselis, S., and Koutselinis, A. (2003a). The toxicology of honey bee poisoning. Vet. Hum. Toxicol. 45(5): 261–265.
- Stefanidou, M., Koutselinis, A., Pappas, F., and Methenitou, G. (1996). Bee head acetylcholinesterase as an indicator of exposure to organophosphate and carbamate insecticides. Vet. Hum. Toxicol. 38(6): 420–422.
- Stefanidou, M., Athanaselis, S., Velonakis, M., Pappas, F., and Koutselinis, A. (2003b). Occupational exposure to cholinesterase inhibiting pesticides: a Greek case. Int. J. Environ. Health Res. 13(1): 23–29.
- Stefanidou, M., Pappas, F., Methenitou, G., Dona, A., Alevisopoulos, G., and Koutselinis, A. (1998). Bee pseudocholinesterase as an indicator of exposure to anticholinesterase insecticides. Vet. Hum. Toxicol. 40(6): 326–327.
- Teixeira, H., et al. (2004). Pesticide intoxications in the centre of Portugal: three years analysis. Forensic Sci. Int. 143: 199–204.
- Timbrell, J.A. (1998). Biomarkers in toxicology. Toxicology 129: 1–12.
- Tsatsakis, A. and Tutudaki, M. (2004). Progress in pesticide and POPs hair analysis for the assessment of exposure. Forensic Sci. Int. 145(2–3): 195–199.
- Tsatsakis, Am., Tzatzarakis, M.N., and Tutudaki, M. (2008). Pesticide levels in head hair samples of Cretan population as an indicator of present and past exposure. Forensic Sci. Int. 21, 176(1): 67–71.
- Tsatsakis, A.M., Tsakalof, A.K., Siatitsas, Y., and Michalodimitrakis, E.N. (1996b). Acute poisoning with carbamate pesticides: the Cretan experience. Sci. Justice 36(1): 35–39.
- Tsatsakis, A.M., Bertsias, G.K., Mammas, I.N., Stiakakis, I., and Georgopoulos, D.B. (2001). Acute fatal poisoning by methomyl caused by inhalation and transdermal absorption. Bull. Environ. Contam. Toxicol 66(4): 415–420.
- Tsatsakis, A.M., Bertsias, G.K., Liakou, V., Mammas, I.N., Stiakakis, I., Tzanakakis, G.N. (2002). Severe fenthion intoxications due to ingestion and inhalation with survival outcome. Hum. Exp. Toxicol. 21(1): 49–54.
-
Tsatsakis, A.M., Manousakis, A., Anastasaki, M., Tzatzarakis, M., Katsanoulas, K., Delaki, C., and Agouridakis, P. (1998). Clinical and toxicological data in fenthion and omethoate acute poisoning. J. Environ. Sci. Health, B33(6): 657–670.
10.1080/03601239809373170 Google Scholar
- Tsatsakis, A.M. et al. (1996a). Experience with acute organophosphate poisonings in Crete. Vet. Hum. Toxicol. 38(2): 101–107.
- Tselas, K. et al. (1998). Chronic exposure in pesticides and effect on the liver of farmers. 9th Cretan Medical Congress, November, Heraklion, Crete, Greece.
- Tsoukali, H. (1990). Pesticides: Toxicity data. Archives de Neuviemme Journees Internationales Mediteraneenes de Medecine Legale, Isola di Capo Rizzuto, Italy, p. 163.
- Tsoukali, H. et al (1986). Poisonings as a cause of death. 72nd Panhellenic Medical Congress, Athens, Greece.
- Tsoukali, H. et al. (1991). Distribution of the pesticide methamidophos in the tissues, according to the toxicological analysis. Abstracts of the 6th Medical Congress of Northern Greece, p. 606, Salonica, Greece.
- Tsoukali-Papadopoulou, H. (2000). Pesticides and toxicity data. In: N.S. Margaris, M. Theodorakakis, and E. Kainadas (Eds) Pesticides, Health and the Environment. Editions Filippoussis, Athens, Greece.
- Tsoukali, E. and Epivatianos, P. (1982). Poisoning cases in northern Greece. 5iemme Journees Internationales Mediteraneenes de Medecine Legale, Nice, France.
- Tsoukali, H. and Njau, S.N. (1987). Mother–fetus postmortem toxicologic analysis in a fatal overdose with mecarbam. Forensic Sci. Int. 35: 249–252.
- Tsoukali, H. and Tsoungas, M. (1996). Fatal human poisonings in Northern Greece: 1990–1995. Vet. Hum. Toxicol. 38(5): 366–367.
- Tzola, E., Fountas, K., Valti, H., Papathanassiou, V.l., Sophidiotou, B., and Vlachos, P. (2000). Poisonings due to pesticides. A study of 131 cases. 26th Panhellenic Medical Congress, Athens, Greece, May 2000.
- Vassiliadis, N., Stavrianos, P., and Tsoukali, H. (1995). Distribution of carbofuran in the tissues, after a lethal poisoning. Archives of the 10th Medical Congress of Northern Greece, Salonica, Greece, p. 906.
- Vlachos, P. (1998). Poisonings from pesticides during the year 1997. 1st Panhellenic Congress of Forensic Medicine and Toxicology, Salonica, Greece.
- Vlachos, P., Kalamara, D., Poulos, L., Panagou, E., and Rapti, P. (1982). Poisonings with pesticides and rodenticides. 2nd Panhellenic Paediateric Congress, Halkidiki, Greece.
- Vougiouklakis, T., Boumba, V.A., and Mitselou, A. (2006). Fatal poisoning in the region of Epirus, Greece, during the period 1998–2004. J. Clin. Forensic Med. 13(6–8): 321–325.
- Waddell, B.L. et al. (2001). Agricultural use of organophosphate pesticides and the risk of non-Hodgkin's lymphoma among male farmers (United States). Cancer Causes Control 12: 509–517.
- Woods, J.S. and Polissar, L. (1989). Non-Hodgkin's lymphoma among phenoxy herbicide-exposed farm workers in western Washington state. Chemosphere 18: 401–406.
- Worek, F., Koller, M., Thierman, H., and Szinicz, L. (2005). Diagnostic aspects of organophosphate poisoning. Toxicology 214: 182–189.
- World Health Organization (WHO) (1985). Manual of Analytical Methods. Course on analytical procedures for assessment of exposure to organophosphorous pesticides, Cremona, Italy, 2–6 September 1985.
