Chapter 11
Cytochrome P450 Degradation and Its Clinical Relevance
Mingxiang Liao,
Ping Kang,
Bernard P. Murray,
Maria Almira Correia,
Mingxiang Liao
Department of DMPK, Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts, USA
Search for more papers by this authorPing Kang
Pharmacokinetics, Dynamics, and Metabolism Department, Pfizer Global Research and Development, San Diego, California, USA
Search for more papers by this authorBernard P. Murray
Drug Metabolism Department, Gilead Sciences, Foster City, California, USA
Search for more papers by this authorMaria Almira Correia
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California, USA
Search for more papers by this authorMingxiang Liao,
Ping Kang,
Bernard P. Murray,
Maria Almira Correia,
Mingxiang Liao
Department of DMPK, Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts, USA
Search for more papers by this authorPing Kang
Pharmacokinetics, Dynamics, and Metabolism Department, Pfizer Global Research and Development, San Diego, California, USA
Search for more papers by this authorBernard P. Murray
Drug Metabolism Department, Gilead Sciences, Foster City, California, USA
Search for more papers by this authorMaria Almira Correia
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California, USA
Search for more papers by this authorBook Editor(s):Chuang Lu,
Albert P. Li,
Chuang Lu
Department of DMPK, Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts, USA
Search for more papers by this authorAlbert P. Li
In Vitro ADMET Laboratories, Columbia, Maryland, USA
Search for more papers by this authorSummary
This chapter contains sections titled:
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Introduction
-
Protein Degradation
-
Individual P 450 Turnover
-
Clinical Relevance of P 450 Degradation
-
Conclusions
-
References
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