Some Problems in the Structural Elucidation of Fungal Metabolites

W. Steglich

W. Steglich

Institut für Organische Chemie und Biochemle der Universitát Bonn, Gerhard-Domagk Straße 1, D-5300 Bonn 1, Federal Republic of Germany

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B. Steffan

B. Steffan

Institut für Organische Chemie und Biochemle der Universitát Bonn, Gerhard-Domagk Straße 1, D-5300 Bonn 1, Federal Republic of Germany

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T. Eizenhöfer

T. Eizenhöfer

Institut für Organische Chemie und Biochemle der Universitát Bonn, Gerhard-Domagk Straße 1, D-5300 Bonn 1, Federal Republic of Germany

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B. Fugmann

B. Fugmann

Institut für Organische Chemie und Biochemle der Universitát Bonn, Gerhard-Domagk Straße 1, D-5300 Bonn 1, Federal Republic of Germany

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R. Herrmann

R. Herrmann

Institut für Organische Chemie und Biochemle der Universitát Bonn, Gerhard-Domagk Straße 1, D-5300 Bonn 1, Federal Republic of Germany

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J.-D. Klamann

J.-D. Klamann

Institut für Organische Chemie und Biochemle der Universitát Bonn, Gerhard-Domagk Straße 1, D-5300 Bonn 1, Federal Republic of Germany

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First published: 28 September 2007
Citations: 1
Book Series:Novartis Foundation Symposia

Summary

In the structural elucidation of natural products, problems may arise owing to extensive signal overlap and line broadening in the NMR spectra as well as unexpected chemical reactions. This is illustrated in the analysis of some novel compounds isolated from fruit bodies of toadstools and slime moulds, including infractopicrin, lascivol, retipolide A, arcyroxepin A and rubroflavin. In some cases, the problems could be solved by spectroscopic techniques such as two-dimensional INADEQUATE experiments, nuclear Overhauser enhancement measurements or X-ray structural analysis; in other cases, chemical transformations were necessary to resolve the structure.

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