Regional sensitivity and coupling of BOLD and CBV changes during stimulation of rat brain
Corresponding Author
Joseph B. Mandeville
MGH-NMR Center, Massachusetts General Hospital, Boston, Massachusetts
Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts
MGH-NMR Center, Room 2301, Building 149, 13th Street, Charlestown, MA 02129===Search for more papers by this authorBruce G. Jenkins
MGH-NMR Center, Massachusetts General Hospital, Boston, Massachusetts
Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts
Search for more papers by this authorBarry E. Kosofsky
Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts
Search for more papers by this authorMichael A. Moskowitz
Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts
Search for more papers by this authorBruce R. Rosen
MGH-NMR Center, Massachusetts General Hospital, Boston, Massachusetts
Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts
Search for more papers by this authorJohn J.A. Marota
Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts
Search for more papers by this authorCorresponding Author
Joseph B. Mandeville
MGH-NMR Center, Massachusetts General Hospital, Boston, Massachusetts
Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts
MGH-NMR Center, Room 2301, Building 149, 13th Street, Charlestown, MA 02129===Search for more papers by this authorBruce G. Jenkins
MGH-NMR Center, Massachusetts General Hospital, Boston, Massachusetts
Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts
Search for more papers by this authorBarry E. Kosofsky
Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts
Search for more papers by this authorMichael A. Moskowitz
Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts
Search for more papers by this authorBruce R. Rosen
MGH-NMR Center, Massachusetts General Hospital, Boston, Massachusetts
Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts
Search for more papers by this authorJohn J.A. Marota
Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts
Search for more papers by this authorAbstract
Functional MRI of rat brain was performed at 2 Tesla following intravenous injection of cocaine in order to 1) determine if changes in CBV and changes in BOLD signal were regionally coupled in brain parenchyma, and 2) compare the sensitivities of these imaging methods across different brain structures. Percent changes in CBV and BOLD relaxation rate were spatially and temporally coupled during this graded brain activation. The use of contrast agent increased functional sensitivity in all parenchymal brain structures, with a strong but predictable dependence on the resting-state blood volume fraction. Magn Reson Med 45:443–447, 2001. © 2001 Wiley-Liss, Inc.
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