Vessel size imaging
Irène Troprès
Unité mixte INSERM/Université Joseph Fourier, Hôpital Albert Michallon, Grenoble, France
Search for more papers by this authorStephan Grimault
Unité mixte INSERM/Université Joseph Fourier, Hôpital Albert Michallon, Grenoble, France
Search for more papers by this authorAlbert Vaeth
Unité mixte INSERM/Université Joseph Fourier, Hôpital Albert Michallon, Grenoble, France
Search for more papers by this authorEmmanuelle Grillon
Unité mixte INSERM/Université Joseph Fourier, Hôpital Albert Michallon, Grenoble, France
Search for more papers by this authorCécile Julien
Unité mixte INSERM/Université Joseph Fourier, Hôpital Albert Michallon, Grenoble, France
Search for more papers by this authorJean-François Payen
Unité mixte INSERM/Université Joseph Fourier, Hôpital Albert Michallon, Grenoble, France
Search for more papers by this authorLaurent Lamalle
Unité mixte INSERM/Université Joseph Fourier, Hôpital Albert Michallon, Grenoble, France
Search for more papers by this authorCorresponding Author
Michel Décorps
Unité mixte INSERM/Université Joseph Fourier, Hôpital Albert Michallon, Grenoble, France
INSERM U438, Hôpital Michallon, BP 217, 38043, Grenoble cédex 9, France===Search for more papers by this authorIrène Troprès
Unité mixte INSERM/Université Joseph Fourier, Hôpital Albert Michallon, Grenoble, France
Search for more papers by this authorStephan Grimault
Unité mixte INSERM/Université Joseph Fourier, Hôpital Albert Michallon, Grenoble, France
Search for more papers by this authorAlbert Vaeth
Unité mixte INSERM/Université Joseph Fourier, Hôpital Albert Michallon, Grenoble, France
Search for more papers by this authorEmmanuelle Grillon
Unité mixte INSERM/Université Joseph Fourier, Hôpital Albert Michallon, Grenoble, France
Search for more papers by this authorCécile Julien
Unité mixte INSERM/Université Joseph Fourier, Hôpital Albert Michallon, Grenoble, France
Search for more papers by this authorJean-François Payen
Unité mixte INSERM/Université Joseph Fourier, Hôpital Albert Michallon, Grenoble, France
Search for more papers by this authorLaurent Lamalle
Unité mixte INSERM/Université Joseph Fourier, Hôpital Albert Michallon, Grenoble, France
Search for more papers by this authorCorresponding Author
Michel Décorps
Unité mixte INSERM/Université Joseph Fourier, Hôpital Albert Michallon, Grenoble, France
INSERM U438, Hôpital Michallon, BP 217, 38043, Grenoble cédex 9, France===Search for more papers by this authorAbstract
Vessel size imaging is a new method that is based on simultaneous measurement of the changes ΔR2 and ΔR
in relaxation rate constants induced by the injection of an intravascular superparamagnetic contrast agent. Using the static dephasing approximation for ΔR
estimation and the slow-diffusion approximation for ΔR2 estimation, it is shown that the ratio ΔR2/ΔR
can be expressed as a function of the susceptibility difference between vessels and brain tissue, the brain water diffusion coefficient, and a weighted mean of vessel sizes. Comparison of the results with 1) the Monte Carlo simulations used to quantify the relationship between tissue parameters and susceptibility contrast, 2) the experimental MRI data in the normal rat brain, and 3) the histologic data establishes the validity of this approach. This technique, which allows images of a weighted mean of the vessel size to be obtained, could be useful for in vivo studies of tumor vascularization. Magn Reson Med 45:397–408, 2001. © 2001 Wiley-Liss, Inc.
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