Slow vasomotor fluctuation in fMRI of anesthetized child brain
Corresponding Author
Vesa Kiviniemi
Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
Department of Diagnostic Radiology, Oulu University Hospital, Kajaanintie 52, 90100 Oulu, Finland===Search for more papers by this authorJukka Jauhiainen
Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
Search for more papers by this authorOsmo Tervonen
Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
Search for more papers by this authorEija Pääkkö
Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
Search for more papers by this authorJarkko Oikarinen
Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
Search for more papers by this authorVilho Vainionpää
Department of Anesthesiology, Oulu University Hospital, Oulu, Finland
Search for more papers by this authorHeikki Rantala
Department of Pediatrics, Oulu University Hospital, Oulu, Finland
Search for more papers by this authorBharat Biswal
Medical College of Wisconsin, Milwaukee, Wisconsin
Search for more papers by this authorCorresponding Author
Vesa Kiviniemi
Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
Department of Diagnostic Radiology, Oulu University Hospital, Kajaanintie 52, 90100 Oulu, Finland===Search for more papers by this authorJukka Jauhiainen
Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
Search for more papers by this authorOsmo Tervonen
Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
Search for more papers by this authorEija Pääkkö
Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
Search for more papers by this authorJarkko Oikarinen
Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
Search for more papers by this authorVilho Vainionpää
Department of Anesthesiology, Oulu University Hospital, Oulu, Finland
Search for more papers by this authorHeikki Rantala
Department of Pediatrics, Oulu University Hospital, Oulu, Finland
Search for more papers by this authorBharat Biswal
Medical College of Wisconsin, Milwaukee, Wisconsin
Search for more papers by this authorAbstract
Signal intensity changes in fMRI during rest caused by vasomotor fluctuations were investigated in this work. Resting-state baseline fluctuations were evaluated in 12 children anesthetized with thiopental. Five subjects had fluctuations related to subvoxel motion. In seven subjects without significant motion, slow signal fluctuation at 0.025–0.041 Hz near one or more primary sensory cortices was observed. In each subject the amplitude and frequency of the fluctuations were stable. It is hypothesized that thiopental, which reduces blood pressure and flow in the cortex, alters the feedback in neurovascular coupling leading to an increase in the magnitude and a reduction in the frequency of these fluctuations. The use of anesthesia in fMRI may provide new insight into neural connectivity and the coupling of blood flow and neural metabolism. Magn Reson Med 44:373–378, 2000. © 2000 Wiley-Liss, Inc.
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