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Chemical Synthesis and DNA Photocleavage of the Intercalator–Carbohydrate Hybrid Moiety of the Neocarzinostatin Chromophore

Kazunobu Toshima Prof. Dr.

[email protected]

Department of Applied Chemistry Faculty of Science and Technology Keio University 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522 (Japan) Fax: (+81) 45-566-1576

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Shigeki Takai,

Shigeki Takai

Department of Applied Chemistry Faculty of Science and Technology Keio University 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522 (Japan) Fax: (+81) 45-566-1576

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Yutaka Maeda,

Yutaka Maeda

Department of Applied Chemistry Faculty of Science and Technology Keio University 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522 (Japan) Fax: (+81) 45-566-1576

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Ryusuke Takano,

Ryusuke Takano

Department of Applied Chemistry Faculty of Science and Technology Keio University 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522 (Japan) Fax: (+81) 45-566-1576

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Shuichi Matsumura Prof. Dr.,

Shuichi Matsumura Prof. Dr.

Department of Applied Chemistry Faculty of Science and Technology Keio University 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522 (Japan) Fax: (+81) 45-566-1576

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Kazunobu Toshima Prof. Dr.,

Kazunobu Toshima Prof. Dr.

[email protected]

Department of Applied Chemistry Faculty of Science and Technology Keio University 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522 (Japan) Fax: (+81) 45-566-1576

Search for more papers by this author

Shigeki Takai,

Shigeki Takai

Department of Applied Chemistry Faculty of Science and Technology Keio University 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522 (Japan) Fax: (+81) 45-566-1576

Search for more papers by this author

Yutaka Maeda,

Yutaka Maeda

Department of Applied Chemistry Faculty of Science and Technology Keio University 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522 (Japan) Fax: (+81) 45-566-1576

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Ryusuke Takano,

Ryusuke Takano

Department of Applied Chemistry Faculty of Science and Technology Keio University 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522 (Japan) Fax: (+81) 45-566-1576

Search for more papers by this author

Shuichi Matsumura Prof. Dr.,

Shuichi Matsumura Prof. Dr.

Department of Applied Chemistry Faculty of Science and Technology Keio University 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522 (Japan) Fax: (+81) 45-566-1576

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First published: 13 October 2000

https://doi.org/10.1002/1521-3773(20001016)39:20<3656::AID-ANIE3656>3.0.CO;2-O

Citations: 21

This research was partially supported by a Grant-in-Aid for Encouragement of Young Scientists from the Ministry of Education, Science, Sports, and Culture, Japan, and a research grant of Keio University Special Grant-in-Aid for Innovative Collaborative Research Projects.

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Abstract

Site-specific DNA cleavage is achieved in the presence of 1 upon irradiation with only long wavelength UV light; no supplementary metallic or reducing agents are required. Compound 1 possesses analogues of the intercalator and carbohydrate moieties found in neocarzinostatin, an antitumor enediene antibiotic.

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Volume39, Issue20

October 16, 2000

Pages 3656-3658

Chemical Synthesis and DNA Photocleavage of the Intercalator–Carbohydrate Hybrid Moiety of the Neocarzinostatin Chromophore

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Chemical Synthesis and DNA Photocleavage of the Intercalator–Carbohydrate Hybrid Moiety of the Neocarzinostatin Chromophore

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