Review
The Interleukin-4-Receptor: From Recognition Mechanism to Pharmacological Target Structure
Peter Reinemer Dr.,
Walter Sebald Prof. Dr.,
Albert Duschl Priv.-Doz. Dr.,
Peter Reinemer Dr.
Bayer AG Pharmaforschung (PH-R LSC-NP) Postfach 101709, 42096 Wuppertal (Germany)
Search for more papers by this authorWalter Sebald Prof. Dr.
Biozentrum der Universität Würzburg Physiologische Chemie II Am Hubland, 97074 Würzburg (Germany) Fax: (+49) 931-888-4113
Search for more papers by this authorAlbert Duschl Priv.-Doz. Dr.
Biozentrum der Universität Würzburg Physiologische Chemie II Am Hubland, 97074 Würzburg (Germany) Fax: (+49) 931-888-4113
Search for more papers by this authorPeter Reinemer Dr.,
Walter Sebald Prof. Dr.,
Albert Duschl Priv.-Doz. Dr.,
Peter Reinemer Dr.
Bayer AG Pharmaforschung (PH-R LSC-NP) Postfach 101709, 42096 Wuppertal (Germany)
Search for more papers by this authorWalter Sebald Prof. Dr.
Biozentrum der Universität Würzburg Physiologische Chemie II Am Hubland, 97074 Würzburg (Germany) Fax: (+49) 931-888-4113
Search for more papers by this authorAlbert Duschl Priv.-Doz. Dr.
Biozentrum der Universität Würzburg Physiologische Chemie II Am Hubland, 97074 Würzburg (Germany) Fax: (+49) 931-888-4113
Search for more papers by this authorFirst published: 11 August 2000
Citations: 15
Abstract
Organic synthesis of hormone derivatives is an established route to yield pharmacologically active agents. Until recently this has only been feasible for small organic compounds, but nowadays it is also possible to produce antagonists for larger protein hormones. In particular, the interleukin-4-receptor was a well-suited target for this approach since it plays a pivotal role in the release and progression of allergic diseases. Accordingly, a strong interest and a high medical need is associated with the development of inhibitors. The structural elucidation of the ligand/receptor complex and an improved understanding of the mechanisms concerning receptor binding and activation allow for the rational design of variants that inhibit interleukin-4. Since it is possible to specifically inhibit the interleukin-4-receptor system in this way, a completely new approach to the development of new drugs against allergy and asthma has been established.
Abstract
Protein hormones exhibit high biological specificity and are therefore regarded as valuable targets for pharmaceutical research and development. The schematically represented hormone interleukin-4 is of particular importance because of its pivotal role in the genesis of allergy and asthma. The recent elucidation of the structure and function of the hormone/receptor complex has opened up new approaches for therapeutic intervention.
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