Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part II: T∗︁2
Corresponding Author
X. Josette Chen
Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina.
Elaine G. Fitzsimons, Box 3302, DUMC, Durham, NC 27710.===Search for more papers by this authorHarald E. Möller
Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina.
Search for more papers by this authorMark S. Chawla
Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina.
Search for more papers by this authorGary P. Cofer
Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina.
Search for more papers by this authorBastiaan Driehuys
Magnetic Imaging Technologies Inc., Durham, North Carolina.
Search for more papers by this authorLaurence W. Hedlund
Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina.
Search for more papers by this authorJames R. MacFall
Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina.
Search for more papers by this authorG. Allan Johnson
Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina.
Search for more papers by this authorCorresponding Author
X. Josette Chen
Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina.
Elaine G. Fitzsimons, Box 3302, DUMC, Durham, NC 27710.===Search for more papers by this authorHarald E. Möller
Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina.
Search for more papers by this authorMark S. Chawla
Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina.
Search for more papers by this authorGary P. Cofer
Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina.
Search for more papers by this authorBastiaan Driehuys
Magnetic Imaging Technologies Inc., Durham, North Carolina.
Search for more papers by this authorLaurence W. Hedlund
Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina.
Search for more papers by this authorJames R. MacFall
Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina.
Search for more papers by this authorG. Allan Johnson
Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina.
Search for more papers by this authorAbstract
The transverse relaxation time, T∗︁2, of hyperpolarized (HP) gas in the lung in vivo is an important parameter for pulse sequence optimization and image contrast. We obtained T∗︁2 maps of HP 3He and 129Xe in guinea pig lungs (n = 17) and in human lungs. Eight different sets of 3He guinea pig studies were acquired, with variation of slice selection, tidal volume, and oxygen level. For example, for a 3He tidal volume of 3 cm3 and no slice selection, the average T∗︁2 in the trachea was 14.7 ms and 8.0 ms in the intrapulmonary airspaces. The equivalent 129Xe experiment yielded an average T∗︁2 of 40.8 ms in the trachea and 18.5 ms in the intrapulmonary airspaces. The average 3He T∗︁2 in the human intrapulmonary airspaces was 9.4 ms. The relaxation behavior was predicted by treating the lung as a porous medium, resulting in good agreement between estimated and measured T∗︁2 values in the intrapulmonary airspaces. Magn Reson Med 42:729–737, 1999. © 1999 Wiley-Liss, Inc.
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