Volume 38, Issue 23 pp. 3495-3497
Communication

A Two-Directional and Highly Convergent Approach for the Synthesis of the Tumor-Associated Antigen Globo-H

Tong Zhu

Tong Zhu

Complex Carbohydrate Research Center, 220 Riverbend Road, Athens, GA 30605, USA, Fax: (+1) 706-542-44-12

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Geert-Jan Boons

Geert-Jan Boons

Complex Carbohydrate Research Center, 220 Riverbend Road, Athens, GA 30605, USA, Fax: (+1) 706-542-44-12

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Abstract

The assembly of six readily available building blocks in five glycosylation steps affords the tumor-associated Globo-H hexasaccharide 1 without the need for any intermediate protecting group manipulations. The aminopropyl spacer is employed for conjugation to carrier proteins.

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