Original Paper

Experimental evaluation of Myracrodruon urundeuva bark extract for antidiarrhoeal activity

M. C. Chaves

Departmento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Centro de Ciências da Saúde, C.P. 3157, 60430-270 Fortaleza, CE, Brazil

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F. A. Santos,

F. A. Santos

Departmento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Centro de Ciências da Saúde, C.P. 3157, 60430-270 Fortaleza, CE, Brazil

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A. M. S. Menezes,

A. M. S. Menezes

Departmento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Centro de Ciências da Saúde, C.P. 3157, 60430-270 Fortaleza, CE, Brazil

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V. S. N. Rao,

Corresponding Author

V. S. N. Rao

Departmento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Centro de Ciências da Saúde, C.P. 3157, 60430-270 Fortaleza, CE, Brazil

Dept.de Fisiologia e Farmacologia (CCS), Rua Cel Nunes de Melo, 1127, C.P. 3157, Porangabussu, 60430-270 Fortaleza, CE, Brazil.Search for more papers by this author

M. C. Chaves,

M. C. Chaves

Departmento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Centro de Ciências da Saúde, C.P. 3157, 60430-270 Fortaleza, CE, Brazil

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F. A. Santos,

F. A. Santos

Departmento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Centro de Ciências da Saúde, C.P. 3157, 60430-270 Fortaleza, CE, Brazil

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A. M. S. Menezes,

A. M. S. Menezes

Departmento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Centro de Ciências da Saúde, C.P. 3157, 60430-270 Fortaleza, CE, Brazil

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V. S. N. Rao,

Corresponding Author

V. S. N. Rao

Departmento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Centro de Ciências da Saúde, C.P. 3157, 60430-270 Fortaleza, CE, Brazil

Dept.de Fisiologia e Farmacologia (CCS), Rua Cel Nunes de Melo, 1127, C.P. 3157, Porangabussu, 60430-270 Fortaleza, CE, Brazil.Search for more papers by this author

First published: 21 December 1998

https://doi.org/10.1002/(SICI)1099-1573(199812)12:8<549::AID-PTR357>3.0.CO;2-L

Citations: 10

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Abstract

The bark of M. urundeuva (Anacardiaceae) used in popular medicine as an antidiarrhoeal agent has been investigated for its effects on castor oil-induced diarrhoea and on intestinal motility. In rats, the ethanol extract of stem bark significantly inhibited the castor oil-induced diarrhoea, small intestinal transit and accumulation of fluid volume at an oral dose of 400 mg/kg. Furthermore, the plant extract caused marked inhibition of the contractile responses evoked by acetylcholine and histamine on guinea-pig ileum in vitro. These results point to a possible antidiarrhoeic effect of M. urundeuva bark extract since inhibition of intestinal motility and secretion can greatly control clinical diarrhoea. Copyright © 1998 John Wiley & Sons, Ltd.

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Volume12, Issue8

December 1998

Pages 549-552

Experimental evaluation of Myracrodruon urundeuva bark extract for antidiarrhoeal activity

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Experimental evaluation of Myracrodruon urundeuva bark extract for antidiarrhoeal activity

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