Comparative genomic hybridization reveals a recurrent pattern of chromosomal aberrations in severe dysplasia/carcinoma in situ of the cervix and in advanced-stage cervical carcinoma
Corresponding Author
Maria Kirchhoff
Chromosome Laboratory, Department of Clinical Genetics, Juliane Marie Center, National University Hospital, Copenhagen, Denmark
Chromosome Laboratory 4051, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.Search for more papers by this authorHanne Rose
Chromosome Laboratory, Department of Clinical Genetics, Juliane Marie Center, National University Hospital, Copenhagen, Denmark
Search for more papers by this authorBodil Laub Petersen
Department of Pathology, Center of Laboratory Medicine and Pathology, National University Hospital, Copenhagen, Denmark
Search for more papers by this authorJan Maahr
Chromosome Laboratory, Department of Clinical Genetics, Juliane Marie Center, National University Hospital, Copenhagen, Denmark
Search for more papers by this authorTommy Gerdes
Chromosome Laboratory, Department of Clinical Genetics, Juliane Marie Center, National University Hospital, Copenhagen, Denmark
Search for more papers by this authorClaes Lundsteen
Chromosome Laboratory, Department of Clinical Genetics, Juliane Marie Center, National University Hospital, Copenhagen, Denmark
Search for more papers by this authorThue Bryndorf
Chromosome Laboratory, Department of Clinical Genetics, Juliane Marie Center, National University Hospital, Copenhagen, Denmark
Search for more papers by this authorNiels Kryger-Baggesen
Department of Gynecology, Juliane Marie Center, National University Hospital, Copenhagen, Denmark
Search for more papers by this authorLise Christensen
Department of Pathology, Center of Laboratory Medicine and Pathology, National University Hospital, Copenhagen, Denmark
Search for more papers by this authorSvend Aage Engelholm
Department of Oncology, Finsen Center, National University Hospital, Copenhagen, Denmark
Search for more papers by this authorJohn Philip
Chromosome Laboratory, Department of Clinical Genetics, Juliane Marie Center, National University Hospital, Copenhagen, Denmark
Search for more papers by this authorCorresponding Author
Maria Kirchhoff
Chromosome Laboratory, Department of Clinical Genetics, Juliane Marie Center, National University Hospital, Copenhagen, Denmark
Chromosome Laboratory 4051, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.Search for more papers by this authorHanne Rose
Chromosome Laboratory, Department of Clinical Genetics, Juliane Marie Center, National University Hospital, Copenhagen, Denmark
Search for more papers by this authorBodil Laub Petersen
Department of Pathology, Center of Laboratory Medicine and Pathology, National University Hospital, Copenhagen, Denmark
Search for more papers by this authorJan Maahr
Chromosome Laboratory, Department of Clinical Genetics, Juliane Marie Center, National University Hospital, Copenhagen, Denmark
Search for more papers by this authorTommy Gerdes
Chromosome Laboratory, Department of Clinical Genetics, Juliane Marie Center, National University Hospital, Copenhagen, Denmark
Search for more papers by this authorClaes Lundsteen
Chromosome Laboratory, Department of Clinical Genetics, Juliane Marie Center, National University Hospital, Copenhagen, Denmark
Search for more papers by this authorThue Bryndorf
Chromosome Laboratory, Department of Clinical Genetics, Juliane Marie Center, National University Hospital, Copenhagen, Denmark
Search for more papers by this authorNiels Kryger-Baggesen
Department of Gynecology, Juliane Marie Center, National University Hospital, Copenhagen, Denmark
Search for more papers by this authorLise Christensen
Department of Pathology, Center of Laboratory Medicine and Pathology, National University Hospital, Copenhagen, Denmark
Search for more papers by this authorSvend Aage Engelholm
Department of Oncology, Finsen Center, National University Hospital, Copenhagen, Denmark
Search for more papers by this authorJohn Philip
Chromosome Laboratory, Department of Clinical Genetics, Juliane Marie Center, National University Hospital, Copenhagen, Denmark
Search for more papers by this authorAbstract
We analyzed 17 cases of dysplasia/carcinoma in situ (CIS) of the cervix and 29 advanced-stage cervical squamous cell carcinomas by comparative genomic hybridization (CGH). A comparable recurrent pattern of aberrations was detected in both preinvasive and invasive cases, although the total number of aberrations was much higher in the latter category. The most consistent chromosomal gain was mapped to chromosome arm 3q in 35% of preinvasive cases and in 72% of invasive cases. Chromosome aberrations were detected in 13/17 preinvasive cases with a total of 61 involved chromosome arms. In the invasive cases, frequent gains also occurred on 1q (45%), 8q (41%), 15q (41%), 5p (34%), and Xq (34%), and frequent losses were mapped to chromosome arms 3p (52%), 11q (48%), 13q (38%), 6q (38%), and 4p (34%). A recurrent pattern of aberrations has not previously been described in preinvasive lesions of the cervix. Our finding is surprising considering that only few preinvasive lesions are expected to progress to invasive cancer. Genes Chromosomes Cancer 24:144–150, 1999. © 1999 Wiley-Liss, Inc.
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