Enzymes of the purine nucleotide cycle in muscle of patients with exercise intolerance
Maria-Grazia Operti MD
Laboratory of Physiological Chemistry, International Institute of Cellular and Molecular Pathology, UCL 75.39, Avenue Hippocrate, 75 B-1200 Brussels, Belgium
Laboratory of Neuropathology, University of Louvain Medical School, Avenue Mouniez 52, B-1200 Brussels, Belgium
Search for more papers by this authorM.-Françoise Vincent MD
Laboratory of Physiological Chemistry, International Institute of Cellular and Molecular Pathology, UCL 75.39, Avenue Hippocrate, 75 B-1200 Brussels, Belgium
Search for more papers by this authorJean-Marie Brucher MD
Laboratory of Neuropathology, University of Louvain Medical School, Avenue Mouniez 52, B-1200 Brussels, Belgium
Search for more papers by this authorCorresponding Author
Georges van den Berghe MD
Laboratory of Physiological Chemistry, International Institute of Cellular and Molecular Pathology, UCL 75.39, Avenue Hippocrate, 75 B-1200 Brussels, Belgium
Laboratory of Physiological Chemistry, International Institute of Cellular and Molecular Pathology, UCL 75.39, Avenue Hippocrate, 75 B-1200 Brussels, BelgiumSearch for more papers by this authorMaria-Grazia Operti MD
Laboratory of Physiological Chemistry, International Institute of Cellular and Molecular Pathology, UCL 75.39, Avenue Hippocrate, 75 B-1200 Brussels, Belgium
Laboratory of Neuropathology, University of Louvain Medical School, Avenue Mouniez 52, B-1200 Brussels, Belgium
Search for more papers by this authorM.-Françoise Vincent MD
Laboratory of Physiological Chemistry, International Institute of Cellular and Molecular Pathology, UCL 75.39, Avenue Hippocrate, 75 B-1200 Brussels, Belgium
Search for more papers by this authorJean-Marie Brucher MD
Laboratory of Neuropathology, University of Louvain Medical School, Avenue Mouniez 52, B-1200 Brussels, Belgium
Search for more papers by this authorCorresponding Author
Georges van den Berghe MD
Laboratory of Physiological Chemistry, International Institute of Cellular and Molecular Pathology, UCL 75.39, Avenue Hippocrate, 75 B-1200 Brussels, Belgium
Laboratory of Physiological Chemistry, International Institute of Cellular and Molecular Pathology, UCL 75.39, Avenue Hippocrate, 75 B-1200 Brussels, BelgiumSearch for more papers by this authorAbstract
The activities of adenylosuccinate synthetase, adenylosuccinate lyase, and adenosine monophosphate deaminase were measured in muscle from patients suffering from fatigue and cramps following exercise. Results denote the existence of secundary deficiencies of adenylosuccinate synthetase and/or adenylosuccinate lyase in subjects with congenital or acquired myopathies. They also suggest that searches are warranted for primary deficiencies of adenylosuccinate synthetase as a cause of exercise intolerance. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21:401–403, 1998.
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