Differences in CTG triplet repeat expansions in an ovarian cancer and cyst from a patient with myotonic dystrophy
Corresponding Author
Masanobu Kinoshita MD
Fourth Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, 1981 Kamoda-Tsujido, Kawagoe, Saitama 350, Japan
Fourth Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, 1981 Kamoda-Tsujido, Kawagoe, Saitama 350, JapanSearch for more papers by this authorAkira Igarashi MD
Department of Research and Development, BML, Inc, Kawagoe-shi, Saitama, Japan
Search for more papers by this authorTetsuo Komori MD
Department of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan
Search for more papers by this authorHirokazu Tamura MD
Fourth Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, 1981 Kamoda-Tsujido, Kawagoe, Saitama 350, Japan
Search for more papers by this authorMasatoshi Hayashi MD
Department of Gynecology, Saitama Medical Center, Saitama Medical School, Saitama, Japan
Search for more papers by this authorKatsuyuki Kinoshita MD, PhD
Department of Gynecology, Saitama Medical Center, Saitama Medical School, Saitama, Japan
Search for more papers by this authorTakeo Deguchi MD
Department of Research and Development, BML, Inc, Kawagoe-shi, Saitama, Japan
Search for more papers by this authorKazuhiko Hirose MD, PhD
Tokyo Metropolitan Fuchu Hospital, Tokyo, Japan
Search for more papers by this authorCorresponding Author
Masanobu Kinoshita MD
Fourth Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, 1981 Kamoda-Tsujido, Kawagoe, Saitama 350, Japan
Fourth Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, 1981 Kamoda-Tsujido, Kawagoe, Saitama 350, JapanSearch for more papers by this authorAkira Igarashi MD
Department of Research and Development, BML, Inc, Kawagoe-shi, Saitama, Japan
Search for more papers by this authorTetsuo Komori MD
Department of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan
Search for more papers by this authorHirokazu Tamura MD
Fourth Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, 1981 Kamoda-Tsujido, Kawagoe, Saitama 350, Japan
Search for more papers by this authorMasatoshi Hayashi MD
Department of Gynecology, Saitama Medical Center, Saitama Medical School, Saitama, Japan
Search for more papers by this authorKatsuyuki Kinoshita MD, PhD
Department of Gynecology, Saitama Medical Center, Saitama Medical School, Saitama, Japan
Search for more papers by this authorTakeo Deguchi MD
Department of Research and Development, BML, Inc, Kawagoe-shi, Saitama, Japan
Search for more papers by this authorKazuhiko Hirose MD, PhD
Tokyo Metropolitan Fuchu Hospital, Tokyo, Japan
Search for more papers by this author
References
- 1 Aaltonen LA, Peltomäki P, Leach FS, Sistonen P, Pylkkänen L, Mecklin J-P, Järvinen H. Powell SM, Jen J, Hamilton SR, Petersen GM, Kinzler KW, Vogelstein B, de la Chapelle A: Clues to pathogenesis of familial colorectal cancer. Science 1993; 260: 812–816.
- 2 Anvret M, Åhlberg G, Grandell U, Hedberg B, Johnson K, Edström L: Larger expansions of the CTG repeat in muscle compared to lymphocytes from patients with myotonic dystrophy. Hum Mol Genet 1993; 2: 1397–1400.
- 3 Brook JD, McCurrach ME, Harley HG, Buckler AJ, Church D, Aburatani H, Hunter K, Stanton VP, Thirion J-P, Hudson T, Sohn R, Zemelman B, Snell RG, Rundle SA, Crow S, Davies J, Shelbourne P, Buxton J, Jones C, Juvonen V, Johnson K, Harper PS, Shaw DJ, Housman DE: Molecular basis of myotonic dystrophy. Expansion of a trinucleotide (CTG) repeat at the 3′ end of a transcript encoding a protein kinase family member. Cell 1992; 68: 799–808.
- 4 Buxton J, Shelbourne P, Davies J, Jones C, Tongeren TV, Aslanidis C, de Jong P, Jansen G, Anvret M, Riley B, Williamson R, Johnson K: Detection of an unstable fragment of DNA specific to individuals with myotonic dystrophy. Nature 1992; 355: 547–548.
- 5 Jansen G, Willems P, Coerwinkel M, Nilleseön W, Smeets H, Vits L, Höweler C, Brunner H, Wieringa B: Gonosomal mosaicism in myotonic dystrophy patients. Involvement of mitotic events in (CTG) n repeat variation and selection against extreme expansion in sperm. Am J Hum Genet 1994; 54: 575–585.
- 6 Kinoshita M, Takahashi R, Hasegawa T, Konori T, Nagasawa R, Hirose K, Tanabe H: (CTG) n expansions in various tissues from a myotonic dystrophy patient. Muscle Nerve 1996; 19: 240–242.
- 7 Mahadevan MS, Amemiya C, Jansen G, Sabourin L, Baird S, Neville EC, Wormskamp N, Segers B, Batzer M, Lamerdin J, de Jong P, Wieringa B, Korneluk RG: Structure and genomic sequence of the myotonic dystrophy (DM kinase) gene. Hum Mol Genet 1993; 2: 299–304.
- 8 Richards RI, Sutherland GR: Simple repeat DNA is not replicated simply. Nat Genet 1994; 6: 114–116.
- 9 Thornton CA, Johnson K, Moxley RT III: Myotonic dystrophy patients have larger CTG expansions in skeletal muscle than in leukocytes. Ann Neurol 1994; 35: 104–107.
- 10 Wöhrle D, Kennerknecht I, Wolf M, Enders H, Schwemmle S, Steinbach P: Heterogeneity of DM kinase repeat expansion in different fetal tissues and further expansion during cell proliferation in vitro: evidence for a causal involvement of methyl-directed DNA mismatch repair in repeat stability. Hum Mol Genet 1995; 4: 1147–1153.
- 11 Wooster R, Cleton-Jansen A-M, Collins N, Mangion J, Cornelis RS, Cooper CS, Gusterson BA, Ponder BAJ, von Deimling A, Wiestler OD, Cornelisse CJ, Devilee P, Stratton MR: Instability of short tandem repeats (microsatellites) in human cancers. Net Genet 1994; 6: 152–156.
Citing Literature
