Experimental Cancer
Inhibition of tumor growth in vivo by hyaluronan oligomers
Chunxun Zeng,
Bryan P. Toole,
Shawn D. Kinney, Jing-wen Kuo, Ivan Stamenkovic,
Chunxun Zeng
Department of Pathology, Harvard Medical School, and Pathology Research Laboratories, Massachusetts General Hospital, Boston, MA, USA
Search for more papers by this authorBryan P. Toole
Department of Anatomy and Cellular Biology, Tufts University Medical Center, Boston, MA, USA
Search for more papers by this authorCorresponding Author
Ivan Stamenkovic
Department of Pathology, Harvard Medical School, and Pathology Research Laboratories, Massachusetts General Hospital, Boston, MA, USA
Pathology Research Laboratories, Massachusetts General Hospital, 149 13th Street, Charlestown Navy Yard, Boston, MA 02129, USA. Fax: (617) 726-5684Search for more papers by this authorChunxun Zeng,
Bryan P. Toole,
Shawn D. Kinney, Jing-wen Kuo, Ivan Stamenkovic,
Chunxun Zeng
Department of Pathology, Harvard Medical School, and Pathology Research Laboratories, Massachusetts General Hospital, Boston, MA, USA
Search for more papers by this authorBryan P. Toole
Department of Anatomy and Cellular Biology, Tufts University Medical Center, Boston, MA, USA
Search for more papers by this authorCorresponding Author
Ivan Stamenkovic
Department of Pathology, Harvard Medical School, and Pathology Research Laboratories, Massachusetts General Hospital, Boston, MA, USA
Pathology Research Laboratories, Massachusetts General Hospital, 149 13th Street, Charlestown Navy Yard, Boston, MA 02129, USA. Fax: (617) 726-5684Search for more papers by this authorFirst published: 06 December 1998
Citations: 177
Abstract
One of the critical events in tumor growth and metastasis is the interaction between tumor cells and host tissue stroma, mediated by different adhesion receptor repertoires in different tumor cell types. Several lines of evidence indicate that interaction between the hyaluronan receptor CD44, expressed on tumor cells, and host tissue stromal hyaluronan can enhance growth and invasiveness of certain tumors. Disruption of CD44-hyaluronan interaction by soluble recombinant CD44 has been shown to inhibit tumor formation by lymphoma and melanoma cells transfected with CD44. Since hyaluronan is a ubiquitous glycosaminoglycan polymer from which oligosaccharides of defined size can be readily purified, we tested the ability of hyaluronan oligomers to inhibit tumor formation by subcutaneously (s.c.) injected B16F10 melanoma cells. Our results indicate that hyaluronan oligomers injected at concentrations as low as 1 mg/ml can markedly inhibit B16F10 melanoma growth, providing a potentially attractive reagent for the control of local tumor development. Int. J. Cancer 77:396–401, 1998. © 1998 Wiley-Liss, Inc.
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