The ratio of free to total prostate-specific antigen in serum is correlated to the prostate volume
Carsten Stephan
Department of Urology, University Hospital Charité, Humboldt University Berlin, Schumannstrasse 20/21, 10098 Berlin, Germany
Search for more papers by this authorCorresponding Author
Klaus Jung
Department of Urology, University Hospital Charité, Humboldt University Berlin, Schumannstrasse 20/21, 10098 Berlin, Germany
Department of Urology, University Hospital Charité, Humboldt University Berlin, Schumannstrasse 20/21, 10098 Berlin, Germany. Fax: (+4930) 2802 1402Search for more papers by this authorMichael Lein
Department of Urology, University Hospital Charité, Humboldt University Berlin, Schumannstrasse 20/21, 10098 Berlin, Germany
Search for more papers by this authorDietmar Schnorr
Department of Urology, University Hospital Charité, Humboldt University Berlin, Schumannstrasse 20/21, 10098 Berlin, Germany
Search for more papers by this authorStefan A. Loening
Department of Urology, University Hospital Charité, Humboldt University Berlin, Schumannstrasse 20/21, 10098 Berlin, Germany
Search for more papers by this authorCarsten Stephan
Department of Urology, University Hospital Charité, Humboldt University Berlin, Schumannstrasse 20/21, 10098 Berlin, Germany
Search for more papers by this authorCorresponding Author
Klaus Jung
Department of Urology, University Hospital Charité, Humboldt University Berlin, Schumannstrasse 20/21, 10098 Berlin, Germany
Department of Urology, University Hospital Charité, Humboldt University Berlin, Schumannstrasse 20/21, 10098 Berlin, Germany. Fax: (+4930) 2802 1402Search for more papers by this authorMichael Lein
Department of Urology, University Hospital Charité, Humboldt University Berlin, Schumannstrasse 20/21, 10098 Berlin, Germany
Search for more papers by this authorDietmar Schnorr
Department of Urology, University Hospital Charité, Humboldt University Berlin, Schumannstrasse 20/21, 10098 Berlin, Germany
Search for more papers by this authorStefan A. Loening
Department of Urology, University Hospital Charité, Humboldt University Berlin, Schumannstrasse 20/21, 10098 Berlin, Germany
Search for more papers by this author
References
- Bangma, C. H., Kranse, R. and Schröder, F. H., Free serum prostate-specific antigen and screening for prostate cancer. J. Amer. med. Ass., 275, 837–838 (1996).
- Björk, T., Hulkko, S., Bjartell, A., Di Sant'Agnese, A., Abrahamsson, P. A. and Lilja, H., Alpha 1-antichymotrypsin production in PSA-producing cells is common in prostate cancer but rare in benign prostatic hyperplasia. Urology, 43, 427–434 (1994).
- Catalona, W. J. and Smith, D. S., Free serum prostate-specific antigen and screening for prostate cancer. J. Amer. med. Ass., 275, 838 (1996).
- Catalona, W. J., Smith, D. S., Wolfert, R. L., Wang, T. J., Rittenhouse, H. G., Ratliff, T. L. and Nadler, R. B., Evaluation of percentage of free serum prostate-specific antigen to improve specificity of prostate cancer screening. J. Amer. med. Ass., 274, 1214–1220 (1995).
- Christensson, A., Björk, T., Nilsson, O., Dahlen, U., Matikainen, M. T., Cockett, A. T. K., Abrahamsson, P. A. and Lilja, H., Serum prostate-specific antigen complexed to α1-antichymotrypsin as an indicator of prostate cancer. J. Urol., 150, 100–105 (1993).
- Filella, X., Alcover, J., Molina, R., Gimenez, N., Rodriguez, A., Jo, J., Carretero, P. and Ballesto, A. M., Clinical usefulness of free PSA fraction as an indicator of prostate cancer. Int. J. Cancer, 63, 780–784 (1995).
- Huber, P. R., Mattarelli, G., Strittmatter, B., Vansteenbrugge, G. J., Schmid, H. P. and Maurer, A., In vivo and in vitro complex formation of prostate-specific antigen with α1-anti-chymotrypsin. Prostate, 27, 166–175 (1995).
- Jung, K., Stephan, C., Lein, M., Henke, W., Schnorr, D., Brux, B., Sch¨︁renkämper, P. and Loening, S. A., Analytical performance and clinical validity of two free prostate-specific antigen assays compared. Clin. Chem., (1996). (In press).
- Leinonen, J., Lövgren, T., Vornanen, T. and Stenman, U. H., Double-label time-resolved immunofluorometric assay of prostate-specific antigen and of its complex with α1-antichymotrypsin. Clin. Chem., 39, 2098–2103 (1993).
- Lilja, H., Regulation of the enzymatic activity of prostate-specific antigen and its reactions with cellular protease inhibitors in prostate cancer. Scand. J. clin. Lab. Invest., 55 (Suppl. 220), 47–56 (1995).
- Lilja, H., Christensson, A., Dahlen, U., Matikainen, M. T., Nilsson, O., Pettersson, K. and Lövgren, T., Prostate-specific antigen in serum occurs predominantly in complex with α1-antichymotrypsin. Clin. Chem., 37, 1618–1625 (1991).
- Oesterling, J. E., Jacobsen, S. J., Klee, G. G., Pettersson, K., Piironen, T., Abrahamsson, P. A., Stenman, U. H., Dowell, B., Lövgren, T. and Lilja, H., Free, complexed and total serum prostate-specific antigen: the establishment of appropriate reference ranges for their concentrations and ratios. J. Urol., 154, 1090–1095 (1995).
- Prestigiacomo, A. and Stamey, T. A., Clinical usefulness of free and complexed PSA. Scand. J. clin. Lab. Invest., 55 (Suppl. 221), 32–34 (1995).
- Stenman, U. H., Leinonen, J., Alfthan, H., Rannikko, S., Tuhkanen, K. and Alfthan, O., A complex between prostate-specific antigen and α1-antichymotrypsin is the major form of prostate-specific antigen in serum of patients with prostatic cancer: assay of the complex improves clinical sensitivity for cancer. Cancer Res., 51, 222–226 (1991).
Citing Literature
