Experimental Cancer

Steroid-hormone receptors in cell lines and tumor biopsies of human lung cancer

Corresponding Author

Ulrich Kaiser

Philipps Universität Marburg, Department of Internal Medicine, Marburg, Germany

Philipps Universität Marburg, Department of Internal Medicine, Division of Hematology/Oncology, Baldinger Strasse, 35033 Marburg, Germany. Fax: (49) 6421-282700Search for more papers by this author

Jürgen Hofmann,

Jürgen Hofmann

Philipps Universität Marburg, Department of Internal Medicine, Marburg, Germany

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Margret Schilli,

Margret Schilli

Philipps Universität Marburg, Department of Internal Medicine, Marburg, Germany

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Bärbel Wegmann,

Bärbel Wegmann

Philipps Universität Marburg, Department of Internal Medicine, Marburg, Germany

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Uwe Klotz,

Uwe Klotz

Philipps Universität Marburg, Department of Internal Medicine, Marburg, Germany

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Steffen Wedel,

Steffen Wedel

Philipps Universität Marburg, Department of Internal Medicine, Marburg, Germany

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Arvind K. Virmani,

Arvind K. Virmani

Simmons Cancer Center, University of Texas Southwestern at Dallas, Dallas, Texas, USA

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Ellen Wollmer,

Ellen Wollmer

Philipps Universität Marburg, Department of Internal Medicine, Marburg, Germany

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Detlev Branscheid,

Detlev Branscheid

Grosshansdorf Hospital, Department of Thoracic Surgery, Grosshansdorf, Germany

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Adi F. Gazdar,

Adi F. Gazdar

Simmons Cancer Center, University of Texas Southwestern at Dallas, Dallas, Texas, USA

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Klaus Havemann,

Klaus Havemann

Philipps Universität Marburg, Department of Internal Medicine, Marburg, Germany

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Ulrich Kaiser,

Corresponding Author

Ulrich Kaiser

Philipps Universität Marburg, Department of Internal Medicine, Marburg, Germany

Philipps Universität Marburg, Department of Internal Medicine, Division of Hematology/Oncology, Baldinger Strasse, 35033 Marburg, Germany. Fax: (49) 6421-282700Search for more papers by this author

Jürgen Hofmann,

Jürgen Hofmann

Philipps Universität Marburg, Department of Internal Medicine, Marburg, Germany

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Margret Schilli,

Margret Schilli

Philipps Universität Marburg, Department of Internal Medicine, Marburg, Germany

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Bärbel Wegmann,

Bärbel Wegmann

Philipps Universität Marburg, Department of Internal Medicine, Marburg, Germany

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Uwe Klotz,

Uwe Klotz

Philipps Universität Marburg, Department of Internal Medicine, Marburg, Germany

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Steffen Wedel,

Steffen Wedel

Philipps Universität Marburg, Department of Internal Medicine, Marburg, Germany

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Arvind K. Virmani,

Arvind K. Virmani

Simmons Cancer Center, University of Texas Southwestern at Dallas, Dallas, Texas, USA

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Ellen Wollmer,

Ellen Wollmer

Philipps Universität Marburg, Department of Internal Medicine, Marburg, Germany

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Detlev Branscheid,

Detlev Branscheid

Grosshansdorf Hospital, Department of Thoracic Surgery, Grosshansdorf, Germany

Search for more papers by this author

Adi F. Gazdar,

Adi F. Gazdar

Simmons Cancer Center, University of Texas Southwestern at Dallas, Dallas, Texas, USA

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Klaus Havemann,

Klaus Havemann

Philipps Universität Marburg, Department of Internal Medicine, Marburg, Germany

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First published: 29 July 1996

https://doi.org/10.1002/(SICI)1097-0215(19960729)67:3<357::AID-IJC9>3.0.CO;2-Q

Citations: 113

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Abstract

Female gender is a significant independent favorable prognostic factor in lung cancer. To study the possible role of sex hormones in lung cancer, the expression of sex-steroid receptors and the glucocorticoid receptor was investigated in 29 lung-cancer cell lines stemming from small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC) by means of immunocytochemistry, ligand-binding assays and RNA expression via polymerase chain reaction. In at least 2 methods of investigation, NSCLC cell lines showed a low expression of estrogen receptor in 6, progesterone receptor in 13 and androgen receptor in 12 out of 17 cases examined; sex-steroid-receptor expression was virtually absent in SCLC cell lines. The glucocorticoid receptor was expressed in all 29 cell lines studied. Additionally, 52 tumor samples from primary lung cancer were investigated for their receptor expression by means of immunohistochemistry. Among patients with primary lung-cancer sex-steroid-receptor expression in tumor biopsies was detected most frequently in female patients (in 69% of 16 cases, vs. 42% of 36 tumors from men) and in patients with adenocarcinoma. Further research will focus on these subgroups. Immunohistology is a feasible method of studying steroid-receptor expression in lung cancer. © 1996 Wiley-Liss, Inc.

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Volume67, Issue3

29 July 1996

Pages 357-364

Steroid-hormone receptors in cell lines and tumor biopsies of human lung cancer

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Steroid-hormone receptors in cell lines and tumor biopsies of human lung cancer

Abstract

References

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