Human Cancer

Characterization of p53 gene mutations in basal-cell carcinomas: Comparison between sun-exposed and less-exposed skin areas

Corresponding Author

Yasuhiro Matsumura

Departments of Radiation Genetics and Dermatology, Faculty of Medicine, Kyoto University, Kyoto, Japan

Department of Radiation Genetics, Faculty of Medicine, Kyoto University, Kyoto 606-01, Japan. Fax: (81)75-753-4419Search for more papers by this author

Chikako Nishigori,

Chikako Nishigori

Departments of Radiation Genetics and Dermatology, Faculty of Medicine, Kyoto University, Kyoto, Japan

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Takashi Yagi,

Takashi Yagi

Departments of Radiation Genetics and Dermatology, Faculty of Medicine, Kyoto University, Kyoto, Japan

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Sadao Imamura,

Sadao Imamura

Departments of Radiation Genetics and Dermatology, Faculty of Medicine, Kyoto University, Kyoto, Japan

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Hiraku Takebe,

Hiraku Takebe

Departments of Radiation Genetics and Dermatology, Faculty of Medicine, Kyoto University, Kyoto, Japan

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Yasuhiro Matsumura,

Corresponding Author

Yasuhiro Matsumura

Departments of Radiation Genetics and Dermatology, Faculty of Medicine, Kyoto University, Kyoto, Japan

Department of Radiation Genetics, Faculty of Medicine, Kyoto University, Kyoto 606-01, Japan. Fax: (81)75-753-4419Search for more papers by this author

Chikako Nishigori,

Chikako Nishigori

Departments of Radiation Genetics and Dermatology, Faculty of Medicine, Kyoto University, Kyoto, Japan

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Takashi Yagi,

Takashi Yagi

Departments of Radiation Genetics and Dermatology, Faculty of Medicine, Kyoto University, Kyoto, Japan

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Sadao Imamura,

Sadao Imamura

Departments of Radiation Genetics and Dermatology, Faculty of Medicine, Kyoto University, Kyoto, Japan

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Hiraku Takebe,

Hiraku Takebe

Departments of Radiation Genetics and Dermatology, Faculty of Medicine, Kyoto University, Kyoto, Japan

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First published: 15 March 1996

https://doi.org/10.1002/(SICI)1097-0215(19960315)65:6<778::AID-IJC12>3.0.CO;2-0

Citations: 22

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Abstract

Mutations in the p53 gene in 32 basal-cell carcinomas (BCC) developed in Japanese patients were identified by the polymerase chain reaction and single-strand-conformation polymorphism analysis, followed by sequencing the DNA. Among 16 BCC developed in continuously sun-exposed areas, 6 tumors showed 7 base substitutions, most of which were G:C to A:T transitions, mainly at the dipyrimidine sites. Seven out of 16 BCC developed in less-exposed areas showed 8 base substitutions, but the majority (75.0%) of them were transversions. These results suggest that the mutation in the p53 gene plays a significant role in the tumorigenesis of BCC developed in less-exposed areas as well as those in sun-exposed areas in Japanese patients. There must be therefore causative factors other than UV irradiation for BCC in less-exposed areas. © 1996 Wiley-Liss, Inc.

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Volume65, Issue6

15 March 1996

Pages 778-780

Characterization of p53 gene mutations in basal-cell carcinomas: Comparison between sun-exposed and less-exposed skin areas

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Characterization of p53 gene mutations in basal-cell carcinomas: Comparison between sun-exposed and less-exposed skin areas

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